Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Eastern Michigan (305) | 62 | 68 | Indiana (61) | Final | W | 6 |
| 2 | 2021-11-12 | Northern Illinois (326) | 49 | 85 | Indiana (46) | Final | W | 36 |
| 3 | 2021-11-17 | St. John's (12) | 74 | 76 | Indiana (46) | Final | W | 2 |
| 4 | 2021-11-21 | Louisiana (178) | 44 | 76 | Indiana (17) | Final | W | 32 |
| 5 | 2021-11-23 | Jackson State (329) | 35 | 70 | Indiana (17) | Final | W | 35 |
| 6 | 2021-11-27 | Marshall (167) | 79 | 90 | Indiana (17) | Final | W | 11 |
| 7 | 2021-11-30 | Indiana (16) | 110 | 112 | Syracuse (162) | Final (2OT) | L | -2 |
| 8 | 2021-12-04 | Nebraska (13) | 55 | 68 | Indiana (46) | Final | W | 13 |
| 9 | 2021-12-08 | Indiana (43) | 59 | 64 | Wisconsin (9) | Final | L | -5 |
| 10 | 2021-12-12 | Merrimack (134) | 49 | 81 | Indiana (46) | Final | W | 32 |
| 11 | 2021-12-18 | Indiana (46) | 64 | 56 | Notre Dame (101) | Final | W | 8 |
| 12 | 2021-12-22 | Northern Kentucky (195) | 61 | 79 | Indiana (46) | Final | W | 18 |
| 13 | 2021-12-29 | UNC-Asheville (244) | 0 | 0 | Indiana (46) | Cancelled | - | - |
| 14 | 2022-01-02 | Indiana (46) | 58 | 61 | Penn State (129) | Final | L | -3 |
| 15 | 2022-01-06 | Ohio State (34) | 51 | 67 | Indiana (46) | Final | W | 16 |
| 16 | 2022-01-09 | Minnesota (46) | 60 | 73 | Indiana (32) | Final | W | 13 |
| 17 | 2022-01-13 | Indiana (46) | 74 | 83 | Iowa (28) | Final | L | -9 |
| 18 | 2022-01-17 | Indiana (40) | 78 | 71 | Nebraska (194) | Final | W | 7 |
| 19 | 2022-01-20 | Purdue (8) | 65 | 68 | Indiana (46) | Final | W | 3 |
| 20 | 2022-01-23 | Michigan (63) | 80 | 62 | Indiana (42) | Final | L | -18 |
| 21 | 2022-01-26 | Penn State (79) | 57 | 74 | Indiana (42) | Final | W | 17 |
| 22 | 2022-01-29 | Indiana (46) | 68 | 55 | Maryland (114) | Final | W | 13 |
| 23 | 2022-02-05 | Illinois (9) | 74 | 57 | Indiana (46) | Final | L | -17 |
| 24 | 2022-02-08 | Indiana (36) | 51 | 59 | Northwestern (88) | Final | L | -8 |
| 25 | 2022-02-12 | Indiana (46) | 61 | 76 | Michigan State (10) | Final | L | -15 |
| 26 | 2022-02-15 | Wisconsin (15) | 74 | 69 | Indiana (45) | Final | L | -5 |
| 27 | 2022-02-21 | Indiana (45) | 69 | 80 | Ohio State (24) | Final | L | -11 |
| 28 | 2022-02-24 | Maryland (93) | 64 | 74 | Indiana (45) | Final | W | 10 |
| 29 | 2022-02-27 | Indiana (44) | 84 | 79 | Minnesota (89) | Final | W | 5 |
| 30 | 2022-03-02 | Rutgers (74) | 66 | 63 | Indiana (44) | Final | L | -3 |
| 31 | 2022-03-05 | Indiana (44) | 67 | 69 | Purdue (9) | Final | L | -2 |
| 32 | 2022-03-10 | Indiana (54) | 74 | 69 | Michigan (41) | Final | W | 5 |
| 33 | 2022-03-11 | Indiana (54) | 65 | 63 | Illinois (17) | Final | W | 2 |
| 34 | 2022-03-12 | Indiana (54) | 77 | 80 | Iowa (25) | Final | L | -3 |
| 35 | 2022-03-15 | Indiana (49) | 66 | 58 | Wyoming (41) | Final | W | 8 |
| 36 | 2022-03-17 | Indiana (49) | 53 | 82 | Saint Mary's (22) | Final | L | -29 |