Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Prairie View A&M (168) | 68 | 87 | Saint Mary's (57) | Final | W | 19 |
| 2 | 2021-11-12 | Texas Southern (317) | 58 | 67 | Saint Mary's (33) | Final | W | 9 |
| 3 | 2021-11-15 | Southern Utah (257) | 51 | 70 | Saint Mary's (91) | Final | W | 19 |
| 4 | 2021-11-17 | Bellarmine (266) | 64 | 73 | Saint Mary's (33) | Final | W | 9 |
| 5 | 2021-11-22 | Saint Mary's (33) | 62 | 59 | Notre Dame (101) | Final | W | 3 |
| 6 | 2021-11-23 | Oregon (110) | 50 | 62 | Saint Mary's (83) | Final | W | 12 |
| 7 | 2021-11-24 | Wisconsin (24) | 61 | 55 | Saint Mary's (33) | Final | L | -6 |
| 8 | 2021-11-29 | UC-Riverside (181) | 50 | 67 | Saint Mary's (60) | Final | W | 17 |
| 9 | 2021-12-02 | Saint Mary's (60) | 60 | 58 | Utah State (55) | Final | W | 2 |
| 10 | 2021-12-04 | Saint Mary's (33) | 58 | 74 | Colorado State (85) | Final | L | -16 |
| 11 | 2021-12-11 | UC-Santa Barbara (171) | 59 | 80 | Saint Mary's (33) | Final | W | 21 |
| 12 | 2021-12-14 | Cal State-Stanislas | 39 | 76 | Saint Mary's (33) | Final | W | 37 |
| 13 | 2021-12-14 | Cal State-Stanislas | 39 | 76 | Saint Mary's (34) | Final | W | 37 |
| 14 | 2021-12-17 | San Diego State (48) | 63 | 53 | Saint Mary's (33) | Final | L | -10 |
| 15 | 2021-12-22 | Missouri State (224) | 58 | 75 | Saint Mary's (33) | Final | W | 17 |
| 16 | 2021-12-28 | Yale (81) | 60 | 87 | Saint Mary's (33) | Final | W | 27 |
| 17 | 2022-01-01 | San Francisco (122) | 0 | 0 | Saint Mary's (33) | Postponed | - | - |
| 18 | 2022-01-06 | Saint Mary's (33) | 0 | 0 | Santa Clara (42) | Postponed | - | - |
| 19 | 2022-01-08 | Saint Mary's (33) | 43 | 52 | BYU (23) | Final | L | -9 |
| 20 | 2022-01-13 | Saint Mary's (33) | 77 | 62 | Pepperdine (283) | Final | W | 15 |
| 21 | 2022-01-15 | Pacific (132) | 0 | 0 | Saint Mary's (33) | Canceled | - | - |
| 22 | 2022-01-20 | Santa Clara (42) | 65 | 73 | Saint Mary's (33) | Final | W | 8 |
| 23 | 2022-01-22 | Saint Mary's (33) | 83 | 51 | Loyola Marymount (184) | Final | W | 32 |
| 24 | 2022-01-27 | Saint Mary's (33) | 72 | 70 | San Francisco (122) | Final | W | 2 |
| 25 | 2022-01-29 | Pepperdine (283) | 57 | 81 | Saint Mary's (33) | Final | W | 24 |
| 26 | 2022-02-03 | Saint Mary's (33) | 75 | 54 | Portland (210) | Final | W | 21 |
| 27 | 2022-02-05 | Loyola Marymount (184) | 60 | 71 | Saint Mary's (33) | Final | W | 11 |
| 28 | 2022-02-08 | Saint Mary's (27) | 72 | 77 | Santa Clara (74) | Final | L | -5 |
| 29 | 2022-02-10 | San Diego (246) | 57 | 86 | Saint Mary's (33) | Final | W | 29 |
| 30 | 2022-02-12 | Saint Mary's (33) | 58 | 74 | Gonzaga (11) | Final | L | -16 |
| 31 | 2022-02-17 | San Francisco (122) | 64 | 69 | Saint Mary's (33) | Final | W | 5 |
| 32 | 2022-02-19 | BYU (62) | 64 | 69 | Saint Mary's (31) | Final | W | 5 |
| 33 | 2022-02-24 | Saint Mary's (27) | 60 | 46 | San Diego (192) | Final | W | 14 |
| 34 | 2022-02-26 | Gonzaga (1) | 57 | 67 | Saint Mary's (27) | Final | W | 10 |
| 35 | 2022-03-07 | Santa Clara (68) | 72 | 75 | Saint Mary's (21) | Final | W | 3 |
| 36 | 2022-03-08 | Saint Mary's (21) | 69 | 82 | Gonzaga (2) | Final | L | -13 |
| 37 | 2022-03-17 | Indiana (49) | 53 | 82 | Saint Mary's (22) | Final | W | 29 |
| 38 | 2022-03-19 | Saint Mary's (22) | 56 | 72 | UCLA (10) | Final | L | -16 |