Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Mount Olive | 70 | 95 | High Point (304) | Final | W | 25 |
| 2 | 2021-11-09 | Shenandoah | 59 | 108 | High Point (304) | Final | W | 49 |
| 3 | 2021-11-12 | High Point (69) | 60 | 95 | Northwestern (75) | Final | L | -35 |
| 4 | 2021-11-16 | High Point (238) | 61 | 70 | Notre Dame (114) | Final | L | -9 |
| 5 | 2021-11-20 | Howard (211) | 63 | 73 | High Point (69) | Final | W | 10 |
| 6 | 2021-11-21 | Georgia State (94) | 74 | 66 | High Point (216) | Final (OT) | L | -8 |
| 7 | 2021-11-27 | Chowan | 60 | 90 | High Point (216) | Final | W | 30 |
| 8 | 2021-11-30 | Furman (96) | 74 | 70 | High Point (244) | Final (2OT) | L | -4 |
| 9 | 2021-12-04 | High Point (69) | 83 | 77 | Elon (232) | Final | W | 6 |
| 10 | 2021-12-07 | Guilford | 59 | 64 | High Point (69) | Final | W | 5 |
| 11 | 2021-12-10 | High Point (245) | 66 | 67 | South Carolina State (332) | Final | L | -1 |
| 12 | 2021-12-18 | UNC-Wilmington (90) | 71 | 69 | High Point (69) | Final/OT | L | -2 |
| 13 | 2021-12-21 | Florida Atlantic (128) | 52 | 55 | High Point (69) | Final | W | 3 |
| 14 | 2021-12-29 | High Point (69) | 68 | 81 | Michigan State (10) | Final | L | -13 |
| 15 | 2021-12-31 | High Point (69) | 48 | 92 | Kentucky (26) | Final | L | -44 |
| 16 | 2022-01-05 | Winthrop (133) | 0 | 0 | High Point (69) | Postponed | - | - |
| 17 | 2022-01-12 | High Point (277) | 65 | 66 | South Carolina Upstate (299) | Final | L | -1 |
| 18 | 2022-01-15 | North Carolina A&T (294) | 71 | 78 | High Point (69) | Final | W | 7 |
| 19 | 2022-01-19 | High Point (69) | 66 | 70 | Charleston Southern (262) | Final | L | -4 |
| 20 | 2022-01-22 | High Point (69) | 64 | 68 | Hampton (260) | Final/OT | L | -4 |
| 21 | 2022-01-24 | Winthrop (133) | 56 | 65 | High Point (69) | Final | W | 9 |
| 22 | 2022-01-26 | Radford (298) | 58 | 63 | High Point (285) | Final | W | 5 |
| 23 | 2022-01-29 | High Point (69) | 72 | 77 | Campbell (191) | Final | L | -5 |
| 24 | 2022-02-02 | Gardner-Webb (213) | 65 | 57 | High Point (264) | Final | L | -8 |
| 25 | 2022-02-05 | UNC-Asheville (244) | 83 | 91 | High Point (69) | Final/OT | W | 8 |
| 26 | 2022-02-09 | High Point (69) | 79 | 70 | Presbyterian (264) | Final | W | 9 |
| 27 | 2022-02-12 | Campbell (191) | 60 | 42 | High Point (69) | Final | L | -18 |
| 28 | 2022-02-15 | High Point (249) | 66 | 70 | Longwood (154) | Final | L | -4 |
| 29 | 2022-02-17 | Longwood (269) | 78 | 71 | High Point (69) | Final | L | -7 |
| 30 | 2022-02-19 | High Point (249) | 64 | 66 | Radford (304) | Final | L | -2 |
| 31 | 2022-02-23 | High Point (264) | 78 | 58 | North Carolina A&T (290) | Final | W | 20 |
| 32 | 2022-02-26 | Hampton (334) | 77 | 88 | High Point (264) | Final | W | 11 |
| 33 | 2022-03-02 | Hampton (332) | 77 | 84 | High Point (256) | Final | W | 7 |
| 34 | 2022-03-04 | High Point (256) | 51 | 68 | Winthrop (135) | Final | L | -17 |