Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Southeastern Louisiana (324) | 67 | 70 | Tulane (155) | Final | W | 3 |
| 2 | 2021-11-13 | Southern (287) | 73 | 70 | Tulane (155) | Final | L | -3 |
| 3 | 2021-11-17 | Tulane (167) | 54 | 59 | Florida State (64) | Final | L | -5 |
| 4 | 2021-11-22 | Tulane (167) | 90 | 87 | Drexel (215) | Final/OT | W | 3 |
| 5 | 2021-11-23 | Tulane (247) | 67 | 68 | Toledo (193) | Final | L | -1 |
| 6 | 2021-11-24 | Valparaiso (156) | 68 | 64 | Tulane (167) | Final | L | -4 |
| 7 | 2021-11-30 | Tulane (254) | 77 | 81 | Charleston (105) | Final | L | -4 |
| 8 | 2021-12-04 | Alcorn State (348) | 64 | 85 | Tulane (167) | Final | W | 21 |
| 9 | 2021-12-07 | Charleston (123) | 86 | 72 | Tulane (167) | Final | L | -14 |
| 10 | 2021-12-14 | Tulane (167) | 0 | 0 | Texas A&M (39) | Cancelled | - | - |
| 11 | 2021-12-18 | Grambling (312) | 0 | 0 | Tulane (167) | Cancelled | - | - |
| 12 | 2021-12-21 | New Orleans (236) | 0 | 0 | Tulane (167) | Cancelled | - | - |
| 13 | 2021-12-29 | Memphis (136) | 84 | 85 | Tulane (167) | Final | W | 1 |
| 14 | 2022-01-01 | Tulane (167) | 68 | 60 | Cincinnati (54) | Final | W | 8 |
| 15 | 2022-01-05 | Tulane (167) | 80 | 88 | East Carolina (252) | Final/OT | L | -8 |
| 16 | 2022-01-08 | South Florida (52) | 54 | 68 | Tulane (167) | Final | W | 14 |
| 17 | 2022-01-12 | Tulane (151) | 68 | 67 | Wichita State (78) | Final | W | 1 |
| 18 | 2022-01-15 | SMU (45) | 75 | 66 | Tulane (167) | Final | L | -9 |
| 19 | 2022-01-22 | Tulane (167) | 66 | 68 | Central Florida (43) | Final | L | -2 |
| 20 | 2022-01-26 | Tulsa (191) | 63 | 97 | Tulane (149) | Final | W | 34 |
| 21 | 2022-01-29 | Wichita State (76) | 66 | 67 | Tulane (167) | Final | W | 1 |
| 22 | 2022-02-02 | Tulane (125) | 62 | 73 | Houston (7) | Final | L | -11 |
| 23 | 2022-02-05 | East Carolina (252) | 66 | 86 | Tulane (167) | Final | W | 20 |
| 24 | 2022-02-09 | Tulane (167) | 69 | 80 | Memphis (136) | Final | L | -11 |
| 25 | 2022-02-12 | Temple (169) | 83 | 92 | Tulane (167) | Final/OT | W | 9 |
| 26 | 2022-02-15 | Tulane (113) | 76 | 57 | South Florida (224) | Final | W | 19 |
| 27 | 2022-02-23 | Houston (13) | 81 | 67 | Tulane (114) | Final | L | -14 |
| 28 | 2022-02-27 | Tulane (117) | 70 | 75 | Temple (97) | Final | L | -5 |
| 29 | 2022-03-03 | Central Florida (76) | 67 | 82 | Tulane (117) | Final | W | 15 |
| 30 | 2022-03-06 | Tulane (113) | 68 | 74 | SMU (45) | Final | L | -6 |
| 31 | 2022-03-11 | Tulane (113) | 69 | 60 | Temple (99) | Final | W | 9 |
| 32 | 2022-03-12 | Tulane (113) | 66 | 86 | Houston (12) | Final | L | -20 |