Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Boston University (167) | 62 | 71 | Rhode Island (138) | Final | L | -9 |
| 2 | 2021-11-12 | Gordon | 61 | 85 | Boston University (267) | Final | W | 24 |
| 3 | 2021-11-16 | Boston University (237) | 48 | 49 | Northeastern (322) | Final | L | -1 |
| 4 | 2021-11-18 | Boston University (237) | 75 | 70 | Hartford (345) | Final | W | 5 |
| 5 | 2021-11-21 | Boston University (187) | 76 | 58 | Northern Illinois (257) | Final | W | 18 |
| 6 | 2021-11-22 | Boston University (267) | 72 | 59 | Sam Houston State (120) | Final | W | 13 |
| 7 | 2021-11-24 | Boston University (267) | 80 | 81 | Florida State (64) | Final/OT | L | -1 |
| 8 | 2021-11-28 | Merrimack (251) | 60 | 61 | Boston University (167) | Final | W | 1 |
| 9 | 2021-12-01 | Boston University (267) | 56 | 54 | George Washington (104) | Final | W | 2 |
| 10 | 2021-12-04 | Binghamton (359) | 63 | 68 | Boston University (267) | Final | W | 5 |
| 11 | 2021-12-08 | UMass-Lowell (149) | 62 | 72 | Boston University (161) | Final | W | 10 |
| 12 | 2021-12-11 | Boston University (267) | 65 | 62 | Dartmouth (256) | Final | W | 3 |
| 13 | 2021-12-18 | Marist (178) | 84 | 79 | Boston University (267) | Final/OT | L | -5 |
| 14 | 2022-01-01 | Bucknell (336) | 61 | 63 | Boston University (267) | Final | W | 2 |
| 15 | 2022-01-04 | Boston University (267) | 71 | 83 | Navy (149) | Final | L | -12 |
| 16 | 2022-01-07 | Loyola-Maryland (325) | 66 | 58 | Boston University (267) | Final | L | -8 |
| 17 | 2022-01-10 | Boston University (195) | 79 | 53 | American (320) | Final | W | 26 |
| 18 | 2022-01-13 | Boston University (267) | 63 | 73 | Army (339) | Final | L | -10 |
| 19 | 2022-01-16 | Navy (126) | 72 | 65 | Boston University (206) | Final | L | -7 |
| 20 | 2022-01-19 | Boston University (267) | 67 | 50 | Loyola-Maryland (325) | Final | W | 17 |
| 21 | 2022-01-22 | Lehigh (276) | 74 | 80 | Boston University (267) | Final | W | 6 |
| 22 | 2022-01-26 | Boston University (198) | 81 | 62 | Lafayette (316) | Final | W | 19 |
| 23 | 2022-01-28 | Colgate (233) | 72 | 76 | Boston University (198) | Final | W | 4 |
| 24 | 2022-01-31 | Holy Cross (348) | 75 | 70 | Boston University (191) | Final | L | -5 |
| 25 | 2022-02-05 | Boston University (267) | 80 | 74 | Lehigh (276) | Final | W | 6 |
| 26 | 2022-02-09 | Army (339) | 74 | 75 | Boston University (267) | Final | W | 1 |
| 27 | 2022-02-12 | American (249) | 67 | 85 | Boston University (267) | Final | W | 18 |
| 28 | 2022-02-16 | Boston University (198) | 78 | 65 | Holy Cross (327) | Final | W | 13 |
| 29 | 2022-02-19 | Boston University (198) | 53 | 72 | Colgate (199) | Final | L | -19 |
| 30 | 2022-02-23 | Lafayette (307) | 60 | 76 | Boston University (202) | Final | W | 16 |
| 31 | 2022-02-26 | Boston University (202) | 78 | 89 | Bucknell (333) | Final | L | -11 |
| 32 | 2022-03-03 | Loyola-Maryland (278) | 64 | 76 | Boston University (208) | Final | W | 12 |
| 33 | 2022-03-06 | Boston University (211) | 80 | 85 | Navy (173) | Final | L | -5 |
| 34 | 2022-03-20 | UNC-Greensboro (167) | 68 | 71 | Boston University (210) | Final | W | 3 |
| 35 | 2022-03-21 | Middle Tennessee (106) | 76 | 46 | Boston University (210) | Final | L | -30 |