Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | North Florida (301) | 74 | 89 | Texas Tech (24) | Final | L | -15 |
| 2 | 2021-11-10 | North Florida (301) | 46 | 64 | Texas A&M (140) | Final | L | -18 |
| 3 | 2021-11-12 | North Florida (345) | 51 | 65 | Grand Canyon (74) | Final | L | -14 |
| 4 | 2021-11-15 | North Florida (323) | 63 | 72 | Arizona State (173) | Final | L | -9 |
| 5 | 2021-11-17 | North Florida (345) | 63 | 98 | UCLA (30) | Final | L | -35 |
| 6 | 2021-11-20 | Webber International | 43 | 103 | North Florida (345) | Final | W | 60 |
| 7 | 2021-11-26 | North Florida (345) | 52 | 86 | Kentucky (26) | Final | L | -34 |
| 8 | 2021-11-28 | North Florida (318) | 69 | 84 | Florida International (94) | Final | L | -15 |
| 9 | 2021-12-02 | Edward Waters | 57 | 103 | North Florida (318) | Final | W | 46 |
| 10 | 2021-12-05 | North Florida (318) | 41 | 76 | Florida Atlantic (253) | Final | L | -35 |
| 11 | 2021-12-08 | North Florida (319) | 55 | 85 | Florida (24) | Final | L | -30 |
| 12 | 2021-12-11 | Austin Peay (138) | 84 | 91 | North Florida (345) | Final | W | 7 |
| 13 | 2021-12-18 | Trinity Baptist | 44 | 92 | North Florida (290) | Final | W | 48 |
| 14 | 2021-12-21 | North Florida (345) | 0 | 0 | Florida State (64) | Postponed | - | - |
| 15 | 2021-12-29 | North Florida (345) | 0 | 0 | Kansas State (96) | Cancelled | - | - |
| 16 | 2021-12-30 | Florida National | 0 | 0 | North Florida (345) | Cancelled | - | - |
| 17 | 2021-12-31 | Keiser | 0 | 0 | North Florida (345) | Cancelled | - | - |
| 18 | 2022-01-05 | North Florida (345) | 67 | 74 | Florida Gulf Coast (241) | Final | L | -7 |
| 19 | 2022-01-08 | Stetson (301) | 68 | 66 | North Florida (345) | Final/OT | L | -2 |
| 20 | 2022-01-11 | North Florida (345) | 56 | 71 | Liberty (93) | Final | L | -15 |
| 21 | 2022-01-15 | Jacksonville (281) | 54 | 51 | North Florida (345) | Final | L | -3 |
| 22 | 2022-01-17 | Kennesaw State (231) | 62 | 60 | North Florida (317) | Final | L | -2 |
| 23 | 2022-01-20 | North Florida (345) | 73 | 86 | Florida State (64) | Final | L | -13 |
| 24 | 2022-01-22 | North Florida (345) | 58 | 67 | Eastern Kentucky (288) | Final | L | -9 |
| 25 | 2022-01-27 | Central Arkansas (143) | 74 | 93 | North Florida (345) | Final | W | 19 |
| 26 | 2022-01-29 | Lipscomb (190) | 77 | 74 | North Florida (345) | Final | L | -3 |
| 27 | 2022-02-03 | North Florida (345) | 88 | 76 | Jacksonville State (227) | Final | W | 12 |
| 28 | 2022-02-05 | North Florida (345) | 71 | 58 | North Alabama (335) | Final | W | 13 |
| 29 | 2022-02-09 | Bellarmine (266) | 73 | 70 | North Florida (345) | Final | L | -3 |
| 30 | 2022-02-12 | North Florida (345) | 74 | 72 | Kennesaw State (142) | Final | W | 2 |
| 31 | 2022-02-15 | Liberty (112) | 69 | 72 | North Florida (283) | Final | W | 3 |
| 32 | 2022-02-19 | Florida Gulf Coast (181) | 64 | 70 | North Florida (283) | Final | W | 6 |
| 33 | 2022-02-23 | North Florida (260) | 39 | 71 | Jacksonville (171) | Final | L | -32 |
| 34 | 2022-02-26 | North Florida (260) | 74 | 69 | Stetson (288) | Final | W | 5 |
| 35 | 2022-03-01 | North Florida (262) | 65 | 74 | Lipscomb (281) | Final | L | -9 |