Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | Drexel (150) | 73 | 89 | Penn | Final | W | 16 |
| 2 | 2021-10-30 | East Stroudsburg | 83 | 91 | Penn | Final | W | 8 |
| 3 | 2021-11-10 | Penn | 70 | 105 | Florida State (20) | Final | L | -35 |
| 4 | 2021-11-12 | Penn (131) | 66 | 87 | George Mason (86) | Final | L | -21 |
| 5 | 2021-11-14 | Penn (131) | 73 | 68 | Bucknell (336) | Final | W | 5 |
| 6 | 2021-11-16 | Lafayette (299) | 57 | 85 | Penn (261) | Final | W | 28 |
| 7 | 2021-11-18 | Penn (261) | 79 | 87 | Utah State (146) | Final (2OT) | L | -8 |
| 8 | 2021-11-19 | Davidson (111) | 72 | 60 | Penn (131) | Final | L | -12 |
| 9 | 2021-11-21 | Penn (202) | 71 | 63 | Old Dominion (263) | Final | W | 8 |
| 10 | 2021-11-23 | Penn (202) | 61 | 76 | Towson (201) | Final | L | -15 |
| 11 | 2021-11-28 | Penn (233) | 60 | 76 | Arkansas (15) | Final | L | -16 |
| 12 | 2021-12-01 | Villanova (29) | 71 | 56 | Penn (131) | Final | L | -15 |
| 13 | 2021-12-04 | Penn (131) | 72 | 81 | Temple (169) | Final | L | -9 |
| 14 | 2021-12-08 | Penn (256) | 71 | 78 | Saint Joseph's (157) | Final | L | -7 |
| 15 | 2021-12-11 | Penn (131) | 74 | 76 | La Salle (237) | Final | L | -2 |
| 16 | 2021-12-28 | James Madison (202) | 0 | 0 | Penn (131) | Cancelled | - | - |
| 17 | 2021-12-31 | Eastern | 0 | 0 | Penn (131) | Cancelled | - | - |
| 18 | 2022-01-02 | Brown (295) | 73 | 77 | Penn (131) | Final | W | 4 |
| 19 | 2022-01-04 | Howard (211) | 0 | 0 | Penn (131) | Canceled | - | - |
| 20 | 2022-01-07 | Cornell (187) | 65 | 79 | Penn (131) | Final | W | 14 |
| 21 | 2022-01-08 | Columbia (193) | 73 | 69 | Penn (131) | Final | L | -4 |
| 22 | 2022-01-15 | Dartmouth (256) | 68 | 78 | Penn (131) | Final | W | 10 |
| 23 | 2022-01-17 | Penn (237) | 64 | 74 | Princeton (97) | Final | L | -10 |
| 24 | 2022-01-22 | Yale (81) | 68 | 76 | Penn (131) | Final | W | 8 |
| 25 | 2022-01-28 | Penn (225) | 78 | 74 | Harvard (223) | Final | W | 4 |
| 26 | 2022-02-04 | Penn (209) | 81 | 66 | Columbia (344) | Final | W | 15 |
| 27 | 2022-02-05 | Penn (131) | 73 | 68 | Cornell (187) | Final | W | 5 |
| 28 | 2022-02-12 | Harvard (181) | 74 | 82 | Penn (131) | Final | W | 8 |
| 29 | 2022-02-18 | Penn (192) | 72 | 81 | Yale (139) | Final | L | -9 |
| 30 | 2022-02-19 | Penn (192) | 89 | 88 | Brown (213) | Final | W | 1 |
| 31 | 2022-02-26 | Penn (196) | 70 | 84 | Dartmouth (278) | Final | L | -14 |
| 32 | 2022-03-05 | Princeton (99) | 93 | 70 | Penn (204) | Final | L | -23 |
| 33 | 2022-03-12 | Penn (207) | 61 | 67 | Yale (141) | Final | L | -6 |