Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | UC-San Diego (242) | 44 | 57 | Loyola Marymount (84) | Final | W | 13 |
| 2 | 2021-11-09 | Chattanooga (133) | 75 | 64 | Loyola Marymount (84) | Final | L | -11 |
| 3 | 2021-11-13 | Arizona Christian | 67 | 74 | Loyola Marymount (84) | Final | W | 7 |
| 4 | 2021-11-17 | Little Rock (321) | 63 | 82 | Loyola Marymount (184) | Final | W | 19 |
| 5 | 2021-11-21 | Florida State (68) | 73 | 45 | Loyola Marymount (215) | Final | L | -28 |
| 6 | 2021-11-22 | Loyola Marymount (184) | 76 | 70 | SMU (45) | Final | W | 6 |
| 7 | 2021-11-27 | Prairie View A&M (339) | 80 | 83 | Loyola Marymount (215) | Final | W | 3 |
| 8 | 2021-11-29 | Grand Canyon (102) | 78 | 72 | Loyola Marymount (154) | Final | L | -6 |
| 9 | 2021-12-04 | Loyola Marymount (184) | 77 | 74 | Long Beach State (278) | Final | W | 3 |
| 10 | 2021-12-07 | Loyola Marymount (184) | 60 | 55 | Tulsa (55) | Final | W | 5 |
| 11 | 2021-12-11 | New Mexico State (207) | 63 | 58 | Loyola Marymount (184) | Final | L | -5 |
| 12 | 2021-12-18 | Loyola Marymount (184) | 63 | 68 | Nevada (67) | Final | L | -5 |
| 13 | 2021-12-21 | Loyola Marymount (184) | 71 | 57 | Bellarmine (266) | Final | W | 14 |
| 14 | 2022-01-01 | Gonzaga (11) | 0 | 0 | Loyola Marymount (184) | Canceled | - | - |
| 15 | 2022-01-13 | Loyola Marymount (184) | 73 | 97 | San Francisco (122) | Final | L | -24 |
| 16 | 2022-01-15 | Loyola Marymount (184) | 65 | 70 | San Diego (246) | Final | L | -5 |
| 17 | 2022-01-17 | Portland (226) | 58 | 70 | Loyola Marymount (164) | Final | W | 12 |
| 18 | 2022-01-20 | Pepperdine (283) | 80 | 85 | Loyola Marymount (184) | Final/OT | W | 5 |
| 19 | 2022-01-22 | Saint Mary's (33) | 83 | 51 | Loyola Marymount (184) | Final | L | -32 |
| 20 | 2022-01-27 | Loyola Marymount (184) | 55 | 89 | Gonzaga (11) | Final | L | -34 |
| 21 | 2022-01-29 | San Diego (246) | 69 | 65 | Loyola Marymount (184) | Final | L | -4 |
| 22 | 2022-02-03 | Loyola Marymount (184) | 60 | 79 | Santa Clara (42) | Final | L | -19 |
| 23 | 2022-02-05 | Loyola Marymount (184) | 60 | 71 | Saint Mary's (33) | Final | L | -11 |
| 24 | 2022-02-10 | BYU (23) | 83 | 82 | Loyola Marymount (184) | Final/OT | L | -1 |
| 25 | 2022-02-12 | Loyola Marymount (184) | 76 | 86 | Portland (210) | Final | L | -10 |
| 26 | 2022-02-17 | Santa Clara (42) | 84 | 80 | Loyola Marymount (184) | Final | L | -4 |
| 27 | 2022-02-19 | Loyola Marymount (196) | 68 | 69 | Pacific (301) | Final | L | -1 |
| 28 | 2022-02-24 | Loyola Marymount (211) | 59 | 79 | BYU (68) | Final | L | -20 |
| 29 | 2022-02-26 | Pacific (294) | 77 | 90 | Loyola Marymount (211) | Final | W | 13 |
| 30 | 2022-03-03 | Pacific (298) | 66 | 86 | Loyola Marymount (209) | Final | W | 20 |
| 31 | 2022-03-04 | Loyola Marymount (209) | 60 | 85 | BYU (59) | Final | L | -25 |