Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Philadelphia Sciences | 54 | 83 | Saint Joseph's (232) | Final | W | 29 |
| 2 | 2021-11-09 | Maryland-Eastern Shore | 67 | 69 | Saint Joseph's (232) | Final | W | 2 |
| 3 | 2021-11-13 | Mount St Mary's (179) | 60 | 80 | Saint Joseph's (232) | Final | W | 20 |
| 4 | 2021-11-17 | Drexel (215) | 78 | 75 | Saint Joseph's (99) | Final | L | -3 |
| 5 | 2021-11-20 | Monmouth (176) | 87 | 75 | Saint Joseph's (99) | Final | L | -12 |
| 6 | 2021-11-25 | USC (71) | 70 | 55 | Saint Joseph's (99) | Final | L | -15 |
| 7 | 2021-11-26 | Saint Joseph's (99) | 77 | 74 | Georgetown (83) | Final | W | 3 |
| 8 | 2021-12-01 | Binghamton (359) | 57 | 79 | Saint Joseph's (99) | Final | W | 22 |
| 9 | 2021-12-04 | Saint Joseph's (99) | 52 | 81 | Villanova (29) | Final | L | -29 |
| 10 | 2021-12-08 | Penn (256) | 71 | 78 | Saint Joseph's (157) | Final | W | 7 |
| 11 | 2021-12-11 | Temple (169) | 49 | 68 | Saint Joseph's (99) | Final | W | 19 |
| 12 | 2021-12-18 | Saint Joseph's (99) | 73 | 77 | Bradley (113) | Final | L | -4 |
| 13 | 2021-12-22 | Holy Cross (334) | 0 | 0 | Saint Joseph's (99) | Cancelled | - | - |
| 14 | 2021-12-30 | Saint Joseph's (99) | 83 | 56 | Richmond (166) | Final | W | 27 |
| 15 | 2022-01-02 | George Washington (104) | 0 | 0 | Saint Joseph's (99) | Postponed | - | - |
| 16 | 2022-01-05 | Davidson (111) | 88 | 73 | Saint Joseph's (99) | Final | L | -15 |
| 17 | 2022-01-08 | Saint Joseph's (99) | 0 | 0 | George Mason (86) | Postponed | - | - |
| 18 | 2022-01-12 | Saint Joseph's (120) | 64 | 75 | Rhode Island (113) | Final | L | -11 |
| 19 | 2022-01-17 | La Salle (264) | 75 | 64 | Saint Joseph's (134) | Final | L | -11 |
| 20 | 2022-01-19 | George Washington (104) | 61 | 72 | Saint Joseph's (99) | Final | W | 11 |
| 21 | 2022-01-22 | Saint Joseph's (99) | 54 | 70 | Virginia Commonwealth (38) | Final | L | -16 |
| 22 | 2022-01-24 | Saint Joseph's (99) | 71 | 77 | George Mason (86) | Final | L | -6 |
| 23 | 2022-01-26 | Duquesne (229) | 61 | 72 | Saint Joseph's (150) | Final | W | 11 |
| 24 | 2022-01-29 | Saint Joseph's (99) | 69 | 80 | St. Bonaventure (146) | Final | L | -11 |
| 25 | 2022-02-05 | Fordham (183) | 69 | 72 | Saint Joseph's (99) | Final | W | 3 |
| 26 | 2022-02-09 | Saint Joseph's (99) | 67 | 73 | Davidson (111) | Final/OT | L | -6 |
| 27 | 2022-02-12 | Saint Joseph's (99) | 67 | 69 | Massachusetts (182) | Final | L | -2 |
| 28 | 2022-02-16 | George Mason (115) | 75 | 70 | Saint Joseph's (164) | Final (OT) | L | -5 |
| 29 | 2022-02-19 | Dayton (68) | 74 | 62 | Saint Joseph's (164) | Final | L | -12 |
| 30 | 2022-02-22 | Saint Joseph's (177) | 61 | 72 | Saint Louis (63) | Final | L | -11 |
| 31 | 2022-02-26 | St. Bonaventure (58) | 54 | 52 | Saint Joseph's (177) | Final | L | -2 |
| 32 | 2022-03-02 | Saint Joseph's (183) | 48 | 49 | La Salle (245) | Final | L | -1 |
| 33 | 2022-03-05 | Rhode Island (140) | 60 | 70 | Saint Joseph's (183) | Final | W | 10 |
| 34 | 2022-03-09 | Saint Joseph's (188) | 56 | 63 | La Salle (227) | Final | L | -7 |