Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | St. Francis (IL) | 0 | 0 | Northern Illinois (337) | Cancelled | - | - |
| 2 | 2021-11-09 | Northern Illinois (337) | 71 | 64 | Washington (213) | Final | W | 7 |
| 3 | 2021-11-12 | Northern Illinois (326) | 49 | 85 | Indiana (46) | Final | L | -36 |
| 4 | 2021-11-18 | Northern Illinois (167) | 37 | 54 | Missouri (128) | Final | L | -17 |
| 5 | 2021-11-21 | Boston University (187) | 76 | 58 | Northern Illinois (257) | Final | L | -18 |
| 6 | 2021-11-22 | Northern Illinois (326) | 60 | 67 | Little Rock (321) | Final | L | -7 |
| 7 | 2021-11-27 | Northern Illinois (257) | 66 | 80 | Marquette (28) | Final | L | -14 |
| 8 | 2021-12-01 | Eastern Illinois (314) | 45 | 55 | Northern Illinois (326) | Final | W | 10 |
| 9 | 2021-12-04 | Northern Illinois (326) | 41 | 79 | Dayton (66) | Final | L | -38 |
| 10 | 2021-12-13 | Northern Illinois (326) | 70 | 59 | Chicago State (351) | Final | W | 11 |
| 11 | 2021-12-19 | Northern Illinois (326) | 60 | 61 | Illinois-Chicago (139) | Final | L | -1 |
| 12 | 2021-12-22 | Indiana State (243) | 0 | 0 | Northern Illinois (326) | Cancelled | - | - |
| 13 | 2021-12-29 | Ball State (298) | 0 | 0 | Northern Illinois (326) | Postponed | - | - |
| 14 | 2022-01-04 | Buffalo (219) | 0 | 0 | Northern Illinois (326) | Postponed | - | - |
| 15 | 2022-01-08 | Northern Illinois (326) | 63 | 94 | Toledo (135) | Final | L | -31 |
| 16 | 2022-01-11 | Northern Illinois (326) | 65 | 63 | Kent State (107) | Final | W | 2 |
| 17 | 2022-01-15 | Eastern Michigan (277) | 70 | 77 | Northern Illinois (326) | Final | W | 7 |
| 18 | 2022-01-18 | Bowling Green (168) | 92 | 83 | Northern Illinois (326) | Final | L | -9 |
| 19 | 2022-01-22 | Northern Illinois (326) | 82 | 85 | Miami (OH) (40) | Final/OT | L | -3 |
| 20 | 2022-01-25 | Northern Illinois (284) | 62 | 74 | Ohio (60) | Final | L | -12 |
| 21 | 2022-01-27 | Ball State (298) | 74 | 67 | Northern Illinois (326) | Final | L | -7 |
| 22 | 2022-01-29 | Central Michigan (311) | 69 | 63 | Northern Illinois (326) | Final | L | -6 |
| 23 | 2022-02-01 | Northern Illinois (291) | 75 | 56 | Western Michigan (345) | Final | W | 19 |
| 24 | 2022-02-05 | Northern Illinois (326) | 65 | 87 | Bowling Green (168) | Final | L | -22 |
| 25 | 2022-02-08 | Akron (121) | 70 | 64 | Northern Illinois (299) | Final | L | -6 |
| 26 | 2022-02-12 | Toledo (135) | 100 | 72 | Northern Illinois (326) | Final | L | -28 |
| 27 | 2022-02-15 | Northern Illinois (300) | 64 | 58 | Ball State (245) | Final | W | 6 |
| 28 | 2022-02-17 | Northern Illinois (326) | 66 | 63 | Akron (59) | Final | W | 3 |
| 29 | 2022-02-19 | Miami (OH) (255) | 78 | 75 | Northern Illinois (300) | Final | L | -3 |
| 30 | 2022-02-22 | Northern Illinois (291) | 72 | 74 | Eastern Michigan (280) | Final | L | -2 |
| 31 | 2022-02-24 | Buffalo (125) | 79 | 68 | Northern Illinois (291) | Final | L | -11 |
| 32 | 2022-02-26 | Northern Illinois (291) | 60 | 70 | Buffalo (125) | Final | L | -10 |
| 33 | 2022-03-01 | Kent State (118) | 63 | 55 | Northern Illinois (297) | Final | L | -8 |
| 34 | 2022-03-04 | Ohio (85) | 57 | 58 | Northern Illinois (297) | Final | W | 1 |