Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-16 | Utah State (44) | 83 | 81 | SMU (54) | Final | L | -2 |
| 2 | 2021-10-23 | Louisiana Tech (70) | 99 | 109 | SMU (54) | Final | W | 10 |
| 3 | 2021-11-09 | McNeese State (318) | 62 | 86 | SMU (54) | Final | W | 24 |
| 4 | 2021-11-12 | SMU (45) | 63 | 86 | Oregon (102) | Final | L | -23 |
| 5 | 2021-11-15 | Northwestern State (306) | 48 | 95 | SMU (179) | Final | W | 47 |
| 6 | 2021-11-18 | Southeastern Louisiana (247) | 61 | 78 | SMU (179) | Final | W | 17 |
| 7 | 2021-11-21 | Missouri (105) | 80 | 75 | SMU (141) | Final (OT) | L | -5 |
| 8 | 2021-11-22 | Loyola Marymount (184) | 76 | 70 | SMU (45) | Final | L | -6 |
| 9 | 2021-11-24 | Sam Houston State (120) | 66 | 75 | SMU (45) | Final | W | 9 |
| 10 | 2021-11-28 | Louisiana-Monroe (277) | 67 | 74 | SMU (173) | Final | W | 7 |
| 11 | 2021-12-01 | UNLV (105) | 64 | 83 | SMU (45) | Final | W | 19 |
| 12 | 2021-12-04 | Vanderbilt (17) | 72 | 84 | SMU (45) | Final | W | 12 |
| 13 | 2021-12-08 | Dayton (95) | 69 | 77 | SMU (116) | Final | W | 8 |
| 14 | 2021-12-19 | SMU (45) | 90 | 72 | New Mexico (49) | Final | W | 18 |
| 15 | 2021-12-21 | Evansville (302) | 0 | 0 | SMU (45) | Cancelled | - | - |
| 16 | 2021-12-29 | SMU (45) | 74 | 69 | Tulsa (55) | Final | W | 5 |
| 17 | 2022-01-02 | Central Florida (43) | 60 | 72 | SMU (45) | Final | W | 12 |
| 18 | 2022-01-06 | SMU (45) | 60 | 77 | Cincinnati (54) | Final | L | -17 |
| 19 | 2022-01-12 | South Florida (243) | 65 | 77 | SMU (72) | Final | W | 12 |
| 20 | 2022-01-15 | SMU (45) | 75 | 66 | Tulane (167) | Final | W | 9 |
| 21 | 2022-01-20 | SMU (45) | 70 | 62 | Memphis (136) | Final | W | 8 |
| 22 | 2022-01-26 | SMU (57) | 74 | 54 | South Florida (204) | Final | W | 20 |
| 23 | 2022-01-29 | Temple (169) | 61 | 69 | SMU (45) | Final | W | 8 |
| 24 | 2022-02-03 | Wichita State (76) | 0 | 0 | SMU (45) | Canceled | - | - |
| 25 | 2022-02-05 | SMU (45) | 57 | 72 | Wichita State (76) | Final | L | -15 |
| 26 | 2022-02-09 | Houston (5) | 83 | 85 | SMU (45) | Final | W | 2 |
| 27 | 2022-02-12 | SMU (45) | 80 | 66 | East Carolina (252) | Final | W | 14 |
| 28 | 2022-02-16 | SMU (42) | 57 | 64 | Temple (107) | Final | L | -7 |
| 29 | 2022-02-20 | Memphis (55) | 57 | 73 | SMU (43) | Final | W | 16 |
| 30 | 2022-02-23 | Tulsa (195) | 61 | 75 | SMU (43) | Final | W | 14 |
| 31 | 2022-02-27 | SMU (48) | 61 | 75 | Houston (10) | Final | L | -14 |
| 32 | 2022-03-03 | Cincinnati (110) | 71 | 76 | SMU (48) | Final | W | 5 |
| 33 | 2022-03-06 | Tulane (113) | 68 | 74 | SMU (45) | Final | W | 6 |
| 34 | 2022-03-11 | Tulsa (197) | 58 | 83 | SMU (45) | Final | W | 25 |
| 35 | 2022-03-12 | Memphis (43) | 70 | 63 | SMU (45) | Final | L | -7 |
| 36 | 2022-03-16 | Nicholls State (250) | 58 | 68 | SMU (45) | Final | W | 10 |
| 37 | 2022-03-20 | Washington State (69) | 75 | 63 | SMU (47) | Final | L | -12 |