Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Rider (288) | 61 | 73 | Duquesne (143) | Final | W | 12 |
| 2 | 2021-11-13 | Hofstra (163) | 73 | 63 | Duquesne (143) | Final | L | -10 |
| 3 | 2021-11-15 | Weber State (159) | 63 | 59 | Duquesne (170) | Final | L | -4 |
| 4 | 2021-11-19 | Northeastern (300) | 71 | 55 | Duquesne (121) | Final | L | -16 |
| 5 | 2021-11-20 | Duquesne (121) | 76 | 84 | Colorado (73) | Final/OT | L | -8 |
| 6 | 2021-11-22 | Bradley (113) | 70 | 78 | Duquesne (121) | Final | W | 8 |
| 7 | 2021-11-28 | American (319) | 79 | 88 | Duquesne (230) | Final | W | 9 |
| 8 | 2021-12-01 | Bowling Green (168) | 78 | 70 | Duquesne (121) | Final | L | -8 |
| 9 | 2021-12-04 | Duquesne (121) | 71 | 72 | Marshall (155) | Final | L | -1 |
| 10 | 2021-12-07 | Duquesne (121) | 67 | 87 | DePaul (95) | Final | L | -20 |
| 11 | 2021-12-11 | New Hampshire (346) | 62 | 64 | Duquesne (121) | Final | W | 2 |
| 12 | 2021-12-19 | UC-Irvine (119) | 54 | 76 | Duquesne (121) | Final | W | 22 |
| 13 | 2021-12-22 | Wofford (221) | 0 | 0 | Duquesne (121) | Cancelled | - | - |
| 14 | 2021-12-30 | Duquesne (121) | 0 | 0 | Davidson (111) | Postponed | - | - |
| 15 | 2022-01-02 | George Mason (86) | 0 | 0 | Duquesne (121) | Canceled | - | - |
| 16 | 2022-01-05 | George Washington (104) | 0 | 0 | Duquesne (121) | Postponed | - | - |
| 17 | 2022-01-08 | Duquesne (121) | 78 | 74 | Massachusetts (182) | Final | W | 4 |
| 18 | 2022-01-12 | Duquesne (192) | 71 | 72 | Fordham (140) | Final | L | -1 |
| 19 | 2022-01-15 | Dayton (66) | 72 | 52 | Duquesne (121) | Final | L | -20 |
| 20 | 2022-01-21 | St. Bonaventure (57) | 64 | 56 | Duquesne (222) | Final | L | -8 |
| 21 | 2022-01-26 | Duquesne (229) | 61 | 72 | Saint Joseph's (150) | Final | L | -11 |
| 22 | 2022-01-29 | Saint Louis (31) | 77 | 53 | Duquesne (121) | Final | L | -24 |
| 23 | 2022-02-01 | Richmond (95) | 74 | 57 | Duquesne (239) | Final | L | -17 |
| 24 | 2022-02-05 | Duquesne (121) | 62 | 71 | Virginia Commonwealth (38) | Final | L | -9 |
| 25 | 2022-02-09 | Duquesne (121) | 54 | 75 | Dayton (66) | Final | L | -21 |
| 26 | 2022-02-12 | Fordham (183) | 65 | 54 | Duquesne (121) | Final | L | -11 |
| 27 | 2022-02-14 | Duquesne (121) | 61 | 72 | Davidson (111) | Final | L | -11 |
| 28 | 2022-02-16 | George Washington (228) | 73 | 52 | Duquesne (259) | Final | L | -21 |
| 29 | 2022-02-19 | Duquesne (259) | 55 | 81 | St. Bonaventure (77) | Final | L | -26 |
| 30 | 2022-02-23 | Davidson (35) | 74 | 50 | Duquesne (268) | Final | L | -24 |
| 31 | 2022-02-26 | Duquesne (268) | 54 | 70 | Rhode Island (144) | Final | L | -16 |
| 32 | 2022-03-02 | Duquesne (276) | 93 | 98 | George Washington (210) | Final | L | -5 |
| 33 | 2022-03-05 | La Salle (245) | 85 | 76 | Duquesne (276) | Final | L | -9 |
| 34 | 2022-03-09 | Duquesne (283) | 77 | 79 | Rhode Island (157) | Final | L | -2 |