Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Stony Brook (241) | 52 | 74 | George Mason (141) | Final | W | 22 |
| 2 | 2021-11-12 | Penn (131) | 66 | 87 | George Mason (86) | Final | W | 21 |
| 3 | 2021-11-14 | Morgan State (337) | 53 | 90 | George Mason (86) | Final | W | 37 |
| 4 | 2021-11-17 | George Mason (86) | 71 | 66 | Maryland (114) | Final | W | 5 |
| 5 | 2021-11-19 | George Mason (86) | 64 | 67 | James Madison (202) | Final | L | -3 |
| 6 | 2021-11-22 | George Mason (86) | 74 | 77 | Washington (72) | Final | L | -3 |
| 7 | 2021-11-23 | Nevada (223) | 88 | 69 | George Mason (34) | Final | L | -19 |
| 8 | 2021-11-24 | George Mason (86) | 76 | 80 | South Dakota State (268) | Final | L | -4 |
| 9 | 2021-12-04 | Old Dominion (254) | 60 | 50 | George Mason (86) | Final | L | -10 |
| 10 | 2021-12-07 | Navy (149) | 65 | 71 | George Mason (86) | Final | W | 6 |
| 11 | 2021-12-18 | George Mason (86) | 80 | 67 | Georgia (35) | Final | W | 13 |
| 12 | 2021-12-21 | American (249) | 44 | 67 | George Mason (86) | Final | W | 23 |
| 13 | 2021-12-23 | George Mason (86) | 0 | 0 | Wisconsin (24) | Cancelled | - | - |
| 14 | 2021-12-23 | Coppin State | 0 | 0 | George Mason | Cancelled | - | - |
| 15 | 2021-12-30 | George Mason (86) | 0 | 0 | Virginia Commonwealth (38) | Postponed | - | - |
| 16 | 2022-01-01 | George Mason (86) | 67 | 76 | Kansas (19) | Final | L | -9 |
| 17 | 2022-01-02 | George Mason (86) | 0 | 0 | Duquesne (121) | Canceled | - | - |
| 18 | 2022-01-05 | Rhode Island (145) | 0 | 0 | George Mason (86) | Canceled | - | - |
| 19 | 2022-01-08 | Saint Joseph's (99) | 0 | 0 | George Mason (86) | Postponed | - | - |
| 20 | 2022-01-11 | George Mason (86) | 0 | 0 | Richmond (166) | Postponed | - | - |
| 21 | 2022-01-17 | George Mason (121) | 76 | 77 | George Washington (292) | Final | L | -1 |
| 22 | 2022-01-22 | Dayton (66) | 49 | 50 | George Mason (86) | Final | W | 1 |
| 23 | 2022-01-24 | Saint Joseph's (99) | 71 | 77 | George Mason (86) | Final | W | 6 |
| 24 | 2022-01-26 | St. Bonaventure (69) | 66 | 75 | George Mason (127) | Final | W | 9 |
| 25 | 2022-01-30 | George Mason (103) | 72 | 62 | Massachusetts (180) | Final | W | 10 |
| 26 | 2022-02-02 | Saint Louis (59) | 92 | 90 | George Mason (103) | Final (2OT) | L | -2 |
| 27 | 2022-02-05 | George Mason (86) | 78 | 83 | La Salle (237) | Final | L | -5 |
| 28 | 2022-02-07 | George Mason (86) | 59 | 62 | Richmond (166) | Final | L | -3 |
| 29 | 2022-02-09 | Richmond (166) | 84 | 87 | George Mason (86) | Final/OT | W | 3 |
| 30 | 2022-02-12 | Virginia Commonwealth (38) | 85 | 70 | George Mason (86) | Final | L | -15 |
| 31 | 2022-02-16 | George Mason (115) | 75 | 70 | Saint Joseph's (164) | Final (OT) | W | 5 |
| 32 | 2022-02-20 | George Mason (123) | 47 | 50 | Fordham (183) | Final | L | -3 |
| 33 | 2022-02-23 | George Mason (123) | 66 | 72 | Virginia Commonwealth (47) | Final | L | -6 |
| 34 | 2022-02-27 | George Washington (210) | 62 | 69 | George Mason (119) | Final | W | 7 |
| 35 | 2022-03-02 | George Mason (119) | 62 | 73 | Davidson (33) | Final | L | -11 |
| 36 | 2022-03-05 | Massachusetts (177) | 83 | 80 | George Mason (119) | Final | L | -3 |
| 37 | 2022-03-10 | George Mason (123) | 49 | 54 | Fordham (179) | Final | L | -5 |