Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Life | 63 | 92 | Austin Peay (243) | Final | W | 29 |
| 2 | 2021-11-09 | Tennessee Southern | 79 | 86 | Austin Peay (243) | Final | W | 7 |
| 3 | 2021-11-12 | Austin Peay (138) | 55 | 73 | Southern Illinois (150) | Final | L | -18 |
| 4 | 2021-11-16 | Austin Peay (307) | 60 | 65 | Purdue Fort Wayne (145) | Final | L | -5 |
| 5 | 2021-11-20 | Austin Peay (138) | 87 | 81 | Dayton (66) | Final | W | 6 |
| 6 | 2021-11-26 | Austin Peay (138) | 69 | 67 | Howard (211) | Final | W | 2 |
| 7 | 2021-11-29 | Austin Peay (224) | 51 | 68 | TCU (85) | Final | L | -17 |
| 8 | 2021-12-05 | Milligan | 55 | 98 | Austin Peay (224) | Final | W | 43 |
| 9 | 2021-12-11 | Austin Peay (138) | 84 | 91 | North Florida (345) | Final | L | -7 |
| 10 | 2021-12-14 | Austin Peay (138) | 51 | 60 | South Florida (52) | Final | L | -9 |
| 11 | 2021-12-18 | Austin Peay (138) | 51 | 77 | Vanderbilt (17) | Final | L | -26 |
| 12 | 2021-12-22 | Western Kentucky (99) | 0 | 0 | Austin Peay (286) | Cancelled | - | - |
| 13 | 2021-12-30 | Tennessee-Martin (205) | 65 | 62 | Austin Peay (138) | Final | L | -3 |
| 14 | 2022-01-01 | Austin Peay (138) | 79 | 98 | Southeast Missouri State (226) | Final | L | -19 |
| 15 | 2022-01-08 | Morehead State (233) | 66 | 55 | Austin Peay (138) | Final | L | -11 |
| 16 | 2022-01-15 | Eastern Illinois (314) | 0 | 0 | Austin Peay (138) | Postponed | - | - |
| 17 | 2022-01-20 | Austin Peay (138) | 72 | 57 | Tennessee-Martin (205) | Final | W | 15 |
| 18 | 2022-01-22 | Austin Peay (138) | 61 | 65 | Tennessee State (165) | Final | L | -4 |
| 19 | 2022-01-27 | Belmont (68) | 75 | 67 | Austin Peay (138) | Final | L | -8 |
| 20 | 2022-01-29 | Austin Peay (138) | 58 | 55 | Tennessee Tech (310) | Final | W | 3 |
| 21 | 2022-01-31 | SIU-Edwardsville (301) | 63 | 68 | Austin Peay (302) | Final (2OT) | W | 5 |
| 22 | 2022-02-03 | Murray State (116) | 65 | 53 | Austin Peay (138) | Final | L | -12 |
| 23 | 2022-02-05 | Austin Peay (138) | 52 | 77 | Morehead State (233) | Final | L | -25 |
| 24 | 2022-02-07 | Austin Peay (138) | 58 | 72 | Belmont (68) | Final | L | -14 |
| 25 | 2022-02-10 | Southeast Missouri State (226) | 66 | 74 | Austin Peay (138) | Final | W | 8 |
| 26 | 2022-02-12 | Tennessee State (165) | 52 | 54 | Austin Peay (138) | Final | W | 2 |
| 27 | 2022-02-14 | Eastern Illinois (314) | 54 | 62 | Austin Peay (138) | Final | W | 8 |
| 28 | 2022-02-17 | Austin Peay (138) | 56 | 91 | Murray State (116) | Final | L | -35 |
| 29 | 2022-02-19 | Tennessee Tech (295) | 73 | 69 | Austin Peay (271) | Final | L | -4 |
| 30 | 2022-02-24 | Austin Peay (275) | 68 | 64 | SIU-Edwardsville (310) | Final | W | 4 |
| 31 | 2022-02-26 | Austin Peay (275) | 64 | 52 | Eastern Illinois (353) | Final | W | 12 |
| 32 | 2022-03-02 | Tennessee Tech (289) | 78 | 51 | Austin Peay (266) | Final | L | -27 |