Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | Hillsdale | 68 | 93 | Toledo (76) | Final | W | 25 |
| 2 | 2021-11-09 | Toledo (76) | 69 | 61 | Valparaiso (245) | Final | W | 8 |
| 3 | 2021-11-13 | Detroit (192) | 73 | 81 | Toledo (76) | Final | W | 8 |
| 4 | 2021-11-17 | Toledo (135) | 59 | 80 | Oakland (172) | Final | L | -21 |
| 5 | 2021-11-22 | Charlotte (173) | 86 | 98 | Toledo (135) | Final | W | 12 |
| 6 | 2021-11-23 | Tulane (247) | 67 | 68 | Toledo (193) | Final | W | 1 |
| 7 | 2021-11-24 | Coastal Carolina (188) | 70 | 79 | Toledo (135) | Final | W | 9 |
| 8 | 2021-11-29 | Northwestern Ohio | 36 | 106 | Toledo (88) | Final | W | 70 |
| 9 | 2021-12-04 | Toledo (135) | 68 | 81 | Michigan State (10) | Final | L | -13 |
| 10 | 2021-12-07 | Bradley (113) | 65 | 67 | Toledo (135) | Final | W | 2 |
| 11 | 2021-12-11 | Toledo (135) | 69 | 72 | Richmond (166) | Final | L | -3 |
| 12 | 2021-12-21 | Marshall (155) | 63 | 95 | Toledo (135) | Final | W | 32 |
| 13 | 2021-12-29 | Western Michigan (304) | 56 | 83 | Toledo (135) | Final | W | 27 |
| 14 | 2022-01-01 | Toledo (135) | 63 | 66 | Kent State (107) | Final | L | -3 |
| 15 | 2022-01-04 | Toledo (135) | 82 | 54 | Central Michigan (311) | Final | W | 28 |
| 16 | 2022-01-08 | Northern Illinois (326) | 63 | 94 | Toledo (135) | Final | W | 31 |
| 17 | 2022-01-11 | Toledo (135) | 75 | 72 | Miami (OH) (40) | Final | W | 3 |
| 18 | 2022-01-15 | Toledo (135) | 91 | 78 | Bowling Green (168) | Final | W | 13 |
| 19 | 2022-01-18 | Ball State (298) | 70 | 83 | Toledo (135) | Final | W | 13 |
| 20 | 2022-01-21 | Toledo (79) | 87 | 69 | Ohio (49) | Final | W | 18 |
| 21 | 2022-01-25 | Buffalo (140) | 75 | 86 | Toledo (65) | Final | W | 11 |
| 22 | 2022-01-28 | Akron (125) | 76 | 84 | Toledo (65) | Final | W | 8 |
| 23 | 2022-02-01 | Toledo (58) | 86 | 66 | Eastern Michigan (261) | Final | W | 20 |
| 24 | 2022-02-04 | Toledo (58) | 83 | 93 | Ball State (236) | Final | L | -10 |
| 25 | 2022-02-08 | Ohio (49) | 62 | 77 | Toledo (71) | Final | W | 15 |
| 26 | 2022-02-12 | Toledo (135) | 100 | 72 | Northern Illinois (326) | Final | W | 28 |
| 27 | 2022-02-15 | Kent State (140) | 72 | 59 | Toledo (63) | Final | L | -13 |
| 28 | 2022-02-19 | Central Michigan (308) | 66 | 68 | Toledo (63) | Final | W | 2 |
| 29 | 2022-02-22 | Toledo (79) | 92 | 50 | Western Michigan (342) | Final | W | 42 |
| 30 | 2022-02-26 | Miami (OH) (251) | 73 | 88 | Toledo (79) | Final | W | 15 |
| 31 | 2022-03-01 | Toledo (75) | 92 | 76 | Buffalo (116) | Final | W | 16 |
| 32 | 2022-03-04 | Bowling Green (270) | 56 | 96 | Toledo (75) | Final | W | 40 |
| 33 | 2022-03-10 | Central Michigan (310) | 71 | 72 | Toledo (69) | Final | W | 1 |
| 34 | 2022-03-11 | Akron (132) | 70 | 62 | Toledo (69) | Final | L | -8 |
| 35 | 2022-03-16 | Dayton (66) | 74 | 55 | Toledo (135) | Final | L | -19 |