Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Hood | 51 | 93 | George Washington (260) | Final | W | 42 |
| 2 | 2021-11-09 | St. Francis (PA) (270) | 72 | 75 | George Washington (260) | Final | W | 3 |
| 3 | 2021-11-11 | George Washington (260) | 64 | 71 | Maryland (40) | Final | L | -7 |
| 4 | 2021-11-13 | George Washington (260) | 55 | 75 | UC-San Diego (242) | Final | L | -20 |
| 5 | 2021-11-16 | George Washington (207) | 59 | 74 | Cal State-Fullerton (281) | Final | L | -15 |
| 6 | 2021-11-19 | UMass-Lowell (319) | 67 | 56 | George Washington (104) | Final | L | -11 |
| 7 | 2021-11-22 | Wright State (124) | 63 | 74 | George Washington (104) | Final | W | 11 |
| 8 | 2021-11-23 | George Washington (275) | 69 | 77 | Kent State (184) | Final | L | -8 |
| 9 | 2021-11-24 | Missouri State (224) | 72 | 54 | George Washington (104) | Final | L | -18 |
| 10 | 2021-12-01 | Boston University (267) | 56 | 54 | George Washington (104) | Final | L | -2 |
| 11 | 2021-12-04 | George Washington (104) | 79 | 86 | Charlotte (173) | Final | L | -7 |
| 12 | 2021-12-08 | Coppin State (331) | 62 | 75 | George Washington (299) | Final | W | 13 |
| 13 | 2021-12-13 | Radford (255) | 58 | 67 | George Washington (104) | Final | W | 9 |
| 14 | 2021-12-22 | Maryland-Eastern Shore (353) | 0 | 0 | George Washington (104) | Cancelled | - | - |
| 15 | 2021-12-30 | St. Bonaventure (146) | 0 | 0 | George Washington (104) | Cancelled | - | - |
| 16 | 2022-01-02 | George Washington (104) | 0 | 0 | Saint Joseph's (99) | Postponed | - | - |
| 17 | 2022-01-05 | George Washington (104) | 0 | 0 | Duquesne (121) | Postponed | - | - |
| 18 | 2022-01-08 | Dayton (66) | 83 | 58 | George Washington (104) | Final | L | -25 |
| 19 | 2022-01-11 | George Washington (104) | 57 | 84 | Virginia Commonwealth (38) | Final | L | -27 |
| 20 | 2022-01-17 | George Mason (121) | 76 | 77 | George Washington (292) | Final | W | 1 |
| 21 | 2022-01-19 | George Washington (104) | 61 | 72 | Saint Joseph's (99) | Final | L | -11 |
| 22 | 2022-01-22 | George Washington (104) | 63 | 61 | Rhode Island (145) | Final | W | 2 |
| 23 | 2022-01-26 | George Washington (256) | 67 | 80 | Saint Louis (62) | Final | L | -13 |
| 24 | 2022-01-30 | Fordham (193) | 55 | 64 | George Washington (245) | Final | W | 9 |
| 25 | 2022-02-02 | La Salle (255) | 87 | 89 | George Washington (245) | Final | W | 2 |
| 26 | 2022-02-05 | Davidson (111) | 78 | 73 | George Washington (104) | Final | L | -5 |
| 27 | 2022-02-09 | George Washington (104) | 77 | 68 | Massachusetts (182) | Final | W | 9 |
| 28 | 2022-02-12 | George Washington (104) | 54 | 80 | Dayton (66) | Final | L | -26 |
| 29 | 2022-02-16 | George Washington (228) | 73 | 52 | Duquesne (259) | Final | W | 21 |
| 30 | 2022-02-19 | Rhode Island (131) | 61 | 72 | George Washington (228) | Final | W | 11 |
| 31 | 2022-02-22 | Richmond (94) | 84 | 71 | George Washington (206) | Final | L | -13 |
| 32 | 2022-02-27 | George Washington (210) | 62 | 69 | George Mason (119) | Final | L | -7 |
| 33 | 2022-03-02 | Duquesne (276) | 93 | 98 | George Washington (210) | Final | W | 5 |
| 34 | 2022-03-05 | George Washington (210) | 66 | 70 | Fordham (184) | Final | L | -4 |
| 35 | 2022-03-10 | Massachusetts (170) | 99 | 88 | George Washington (216) | Final | L | -11 |