Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Sacred Heart (235) | 86 | 81 | La Salle (219) | Final (OT) | L | -5 |
| 2 | 2021-11-13 | Albany (218) | 64 | 67 | La Salle (219) | Final | W | 3 |
| 3 | 2021-11-17 | La Salle (237) | 82 | 85 | Delaware (287) | Final/OT | L | -3 |
| 4 | 2021-11-20 | Army (339) | 58 | 61 | La Salle (237) | Final | W | 3 |
| 5 | 2021-11-28 | Villanova (46) | 72 | 46 | La Salle (239) | Final | L | -26 |
| 6 | 2021-12-01 | La Salle (237) | 57 | 73 | Temple (169) | Final | L | -16 |
| 7 | 2021-12-04 | Holy Cross (334) | 65 | 84 | La Salle (237) | Final | W | 19 |
| 8 | 2021-12-07 | Fairleigh Dickinson (343) | 55 | 81 | La Salle (237) | Final | W | 26 |
| 9 | 2021-12-11 | Penn (131) | 74 | 76 | La Salle (237) | Final | W | 2 |
| 10 | 2021-12-18 | La Salle (237) | 70 | 82 | Bucknell (336) | Final | L | -12 |
| 11 | 2021-12-21 | Drexel (215) | 0 | 0 | La Salle (237) | Cancelled | - | - |
| 12 | 2021-12-30 | Fordham (183) | 69 | 61 | La Salle (237) | Final | L | -8 |
| 13 | 2022-01-05 | La Salle (237) | 0 | 0 | Saint Louis (31) | Postponed | - | - |
| 14 | 2022-01-08 | Virginia Commonwealth (38) | 85 | 66 | La Salle (237) | Final | L | -19 |
| 15 | 2022-01-11 | St. Bonaventure (146) | 80 | 76 | La Salle (237) | Final/OT | L | -4 |
| 16 | 2022-01-17 | La Salle (264) | 75 | 64 | Saint Joseph's (134) | Final | W | 11 |
| 17 | 2022-01-19 | La Salle (237) | 54 | 56 | Rhode Island (145) | Final | L | -2 |
| 18 | 2022-01-22 | Richmond (166) | 64 | 56 | La Salle (237) | Final | L | -8 |
| 19 | 2022-01-26 | Massachusetts (175) | 77 | 71 | La Salle (245) | Final | L | -6 |
| 20 | 2022-01-29 | La Salle (237) | 69 | 77 | Davidson (111) | Final | L | -8 |
| 21 | 2022-02-02 | La Salle (255) | 87 | 89 | George Washington (245) | Final | L | -2 |
| 22 | 2022-02-05 | George Mason (86) | 78 | 83 | La Salle (237) | Final | W | 5 |
| 23 | 2022-02-08 | Saint Louis (43) | 75 | 57 | La Salle (245) | Final | L | -18 |
| 24 | 2022-02-12 | La Salle (237) | 63 | 77 | Richmond (166) | Final | L | -14 |
| 25 | 2022-02-16 | La Salle (253) | 64 | 90 | Saint Louis (53) | Final | L | -26 |
| 26 | 2022-02-19 | La Salle (253) | 74 | 80 | Massachusetts (166) | Final | L | -6 |
| 27 | 2022-02-23 | La Salle (258) | 54 | 60 | Fordham (183) | Final | L | -6 |
| 28 | 2022-02-26 | Dayton (61) | 60 | 62 | La Salle (258) | Final | W | 2 |
| 29 | 2022-03-02 | Saint Joseph's (183) | 48 | 49 | La Salle (245) | Final | W | 1 |
| 30 | 2022-03-05 | La Salle (245) | 85 | 76 | Duquesne (276) | Final | W | 9 |
| 31 | 2022-03-09 | Saint Joseph's (188) | 56 | 63 | La Salle (227) | Final | W | 7 |
| 32 | 2022-03-10 | La Salle (227) | 51 | 71 | Saint Louis (56) | Final | L | -20 |