Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-26 | Rockhurst | 0 | 0 | Saint Louis (53) | Cancelled | - | - |
| 2 | 2021-10-31 | Lindenwood | 66 | 89 | Saint Louis (53) | Final | W | 23 |
| 3 | 2021-11-09 | Central Arkansas (326) | 61 | 96 | Saint Louis (53) | Final | W | 35 |
| 4 | 2021-11-10 | Harris Stowe | 54 | 127 | Saint Louis (53) | Final | W | 73 |
| 5 | 2021-11-12 | Eastern Illinois (314) | 44 | 86 | Saint Louis (31) | Final | W | 42 |
| 6 | 2021-11-16 | Saint Louis (14) | 74 | 90 | Memphis (35) | Final | L | -16 |
| 7 | 2021-11-20 | Mercer (174) | 58 | 75 | Saint Louis (31) | Final | W | 17 |
| 8 | 2021-11-23 | Illinois State (213) | 76 | 82 | Saint Louis (70) | Final | W | 6 |
| 9 | 2021-11-24 | Stephen F. Austin (88) | 68 | 79 | Saint Louis (31) | Final | W | 11 |
| 10 | 2021-11-30 | Saint Louis (58) | 86 | 82 | Boise State (106) | Final (OT) | W | 4 |
| 11 | 2021-12-04 | UAB (115) | 77 | 72 | Saint Louis (31) | Final | L | -5 |
| 12 | 2021-12-07 | Belmont (68) | 64 | 59 | Saint Louis (31) | Final | L | -5 |
| 13 | 2021-12-11 | Boston College (151) | 68 | 79 | Saint Louis (31) | Final | W | 11 |
| 14 | 2021-12-18 | Auburn (37) | 74 | 70 | Saint Louis (31) | Final | L | -4 |
| 15 | 2021-12-22 | Saint Louis | 0 | 0 | Drake | Cancelled | - | - |
| 16 | 2021-12-30 | Saint Louis (31) | 0 | 0 | Massachusetts (182) | Postponed | - | - |
| 17 | 2022-01-02 | Richmond (166) | 69 | 76 | Saint Louis (31) | Final | W | 7 |
| 18 | 2022-01-05 | La Salle (237) | 0 | 0 | Saint Louis (31) | Postponed | - | - |
| 19 | 2022-01-08 | Iona (220) | 67 | 68 | Saint Louis (31) | Final | W | 1 |
| 20 | 2022-01-11 | Saint Louis (31) | 63 | 68 | Dayton (66) | Final | L | -5 |
| 21 | 2022-01-15 | Fordham (183) | 45 | 63 | Saint Louis (31) | Final | W | 18 |
| 22 | 2022-01-20 | Saint Louis (31) | 85 | 91 | Massachusetts (182) | Final | L | -6 |
| 23 | 2022-01-23 | Massachusetts (175) | 59 | 90 | Saint Louis (62) | Final | W | 31 |
| 24 | 2022-01-26 | George Washington (256) | 67 | 80 | Saint Louis (62) | Final | W | 13 |
| 25 | 2022-01-29 | Saint Louis (31) | 77 | 53 | Duquesne (121) | Final | W | 24 |
| 26 | 2022-02-02 | Saint Louis (59) | 92 | 90 | George Mason (103) | Final (2OT) | W | 2 |
| 27 | 2022-02-05 | Dayton (66) | 61 | 72 | Saint Louis (31) | Final | W | 11 |
| 28 | 2022-02-08 | Saint Louis (43) | 75 | 57 | La Salle (245) | Final | W | 18 |
| 29 | 2022-02-11 | St. Bonaventure (146) | 68 | 61 | Saint Louis (31) | Final | L | -7 |
| 30 | 2022-02-14 | Saint Louis (31) | 79 | 83 | St. Bonaventure (146) | Final | L | -4 |
| 31 | 2022-02-16 | La Salle (253) | 64 | 90 | Saint Louis (53) | Final | W | 26 |
| 32 | 2022-02-19 | Saint Louis (53) | 58 | 79 | Davidson (38) | Final | L | -21 |
| 33 | 2022-02-22 | Saint Joseph's (177) | 61 | 72 | Saint Louis (63) | Final | W | 11 |
| 34 | 2022-02-25 | Saint Louis (63) | 66 | 68 | Richmond (94) | Final | L | -2 |
| 35 | 2022-03-02 | Saint Louis (64) | 80 | 74 | Rhode Island (140) | Final | W | 6 |
| 36 | 2022-03-05 | Virginia Commonwealth (43) | 65 | 69 | Saint Louis (64) | Final | W | 4 |
| 37 | 2022-03-10 | La Salle (227) | 51 | 71 | Saint Louis (56) | Final | W | 20 |
| 38 | 2022-03-11 | Saint Louis (56) | 57 | 56 | St. Bonaventure (57) | Final | W | 1 |
| 39 | 2022-03-12 | Saint Louis (56) | 69 | 84 | Davidson (36) | Final | L | -15 |
| 40 | 2022-03-16 | Northern Iowa (89) | 80 | 68 | Saint Louis (31) | Final | L | -12 |