Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Illinois Tech | 59 | 76 | Illinois-Chicago (284) | Final | W | 17 |
| 2 | 2021-11-09 | Illinois-Chicago (284) | 54 | 64 | Dayton (89) | Final | L | -10 |
| 3 | 2021-11-13 | Illinois-Chicago (284) | 74 | 70 | Valparaiso (245) | Final | W | 4 |
| 4 | 2021-11-16 | Trinity (IL) | 50 | 91 | Illinois-Chicago (214) | Final | W | 41 |
| 5 | 2021-11-20 | Illinois-Chicago (139) | 63 | 80 | Loyola-Chicago (263) | Final | L | -17 |
| 6 | 2021-11-25 | Illinois-Chicago (139) | 80 | 88 | Hawaii (109) | Final | L | -8 |
| 7 | 2021-11-26 | Illinois-Chicago (139) | 52 | 64 | San Diego (246) | Final | L | -12 |
| 8 | 2021-12-02 | Oakland (47) | 81 | 77 | Illinois-Chicago (275) | Final | L | -4 |
| 9 | 2021-12-05 | Detroit (314) | 64 | 56 | Illinois-Chicago (275) | Final | L | -8 |
| 10 | 2021-12-11 | Illinois-Chicago (139) | 71 | 67 | Central Michigan (311) | Final | W | 4 |
| 11 | 2021-12-14 | DePaul (95) | 72 | 66 | Illinois-Chicago (139) | Final | L | -6 |
| 12 | 2021-12-19 | Northern Illinois (326) | 60 | 61 | Illinois-Chicago (139) | Final | W | 1 |
| 13 | 2021-12-30 | Purdue Fort Wayne (266) | 0 | 0 | Illinois-Chicago (260) | Cancelled | - | - |
| 14 | 2022-01-01 | Cleveland State (308) | 0 | 0 | Illinois-Chicago (139) | Canceled | - | - |
| 15 | 2022-01-06 | Illinois-Chicago (139) | 72 | 90 | Wright State (124) | Final | L | -18 |
| 16 | 2022-01-08 | Illinois-Chicago (139) | 0 | 0 | Northern Kentucky (195) | Canceled | - | - |
| 17 | 2022-01-10 | Illinois-Chicago (281) | 67 | 65 | IUPUI (357) | Final | W | 2 |
| 18 | 2022-01-13 | Illinois-Chicago (139) | 81 | 77 | Milwaukee (261) | Final | W | 4 |
| 19 | 2022-01-15 | Illinois-Chicago (139) | 80 | 63 | Green Bay (206) | Final | W | 17 |
| 20 | 2022-01-20 | Northern Kentucky (195) | 74 | 70 | Illinois-Chicago (139) | Final/OT | L | -4 |
| 21 | 2022-01-22 | Wright State (124) | 97 | 81 | Illinois-Chicago (139) | Final | L | -16 |
| 22 | 2022-01-27 | Illinois-Chicago (139) | 67 | 80 | Detroit (212) | Final | L | -13 |
| 23 | 2022-01-29 | Illinois-Chicago (139) | 74 | 81 | Oakland (172) | Final | L | -7 |
| 24 | 2022-02-03 | Robert Morris (148) | 75 | 80 | Illinois-Chicago (139) | Final | W | 5 |
| 25 | 2022-02-05 | Youngstown State (231) | 66 | 64 | Illinois-Chicago (139) | Final | L | -2 |
| 26 | 2022-02-10 | Illinois-Chicago (139) | 76 | 75 | Cleveland State (308) | Final | W | 1 |
| 27 | 2022-02-12 | Illinois-Chicago (139) | 66 | 73 | Purdue Fort Wayne (222) | Final | L | -7 |
| 28 | 2022-02-14 | IUPUI (358) | 54 | 57 | Illinois-Chicago (279) | Final | W | 3 |
| 29 | 2022-02-17 | Illinois-Chicago (139) | 79 | 88 | Youngstown State (231) | Final | L | -9 |
| 30 | 2022-02-19 | Illinois-Chicago (279) | 96 | 88 | Robert Morris (320) | Final | W | 8 |
| 31 | 2022-02-24 | Green Bay (349) | 77 | 81 | Illinois-Chicago (283) | Final | W | 4 |
| 32 | 2022-02-26 | Milwaukee (321) | 58 | 71 | Illinois-Chicago (283) | Final | W | 13 |
| 33 | 2022-03-01 | Illinois-Chicago (279) | 80 | 69 | Milwaukee (324) | Final | W | 11 |
| 34 | 2022-03-03 | Illinois-Chicago (279) | 72 | 78 | Purdue Fort Wayne (199) | Final | L | -6 |