Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Virginia State | 55 | 74 | Virginia Commonwealth (38) | Final | W | 19 |
| 2 | 2021-11-09 | Saint Peter's (187) | 54 | 57 | Virginia Commonwealth (38) | Final | W | 3 |
| 3 | 2021-11-13 | Wagner (160) | 58 | 44 | Virginia Commonwealth (38) | Final | L | -14 |
| 4 | 2021-11-17 | Virginia Commonwealth (38) | 48 | 37 | Vanderbilt (17) | Final | W | 11 |
| 5 | 2021-11-20 | Chattanooga (291) | 56 | 54 | Virginia Commonwealth (38) | Final | L | -2 |
| 6 | 2021-11-24 | Virginia Commonwealth (38) | 67 | 55 | Syracuse (84) | Final | W | 12 |
| 7 | 2021-11-25 | Baylor (58) | 69 | 61 | Virginia Commonwealth (38) | Final | L | -8 |
| 8 | 2021-11-26 | Virginia Commonwealth (38) | 63 | 70 | Connecticut (4) | Final/OT | L | -7 |
| 9 | 2021-12-04 | Campbell (191) | 61 | 65 | Virginia Commonwealth (38) | Final | W | 4 |
| 10 | 2021-12-08 | Jacksonville State (223) | 52 | 66 | Virginia Commonwealth (86) | Final | W | 14 |
| 11 | 2021-12-11 | Virginia Commonwealth (38) | 75 | 66 | Old Dominion (254) | Final | W | 9 |
| 12 | 2021-12-15 | Florida Atlantic (128) | 46 | 66 | Virginia Commonwealth (38) | Final | W | 20 |
| 13 | 2021-12-18 | Penn State (129) | 0 | 0 | Virginia Commonwealth (38) | Cancelled | - | - |
| 14 | 2021-12-21 | New Hampshire (346) | 0 | 0 | Virginia Commonwealth (38) | Cancelled | - | - |
| 15 | 2021-12-30 | George Mason (86) | 0 | 0 | Virginia Commonwealth (38) | Postponed | - | - |
| 16 | 2022-01-02 | Davidson (111) | 0 | 0 | Virginia Commonwealth (38) | Postponed | - | - |
| 17 | 2022-01-05 | Virginia Commonwealth (38) | 53 | 52 | Dayton (66) | Final | W | 1 |
| 18 | 2022-01-08 | Virginia Commonwealth (38) | 85 | 66 | La Salle (237) | Final | W | 19 |
| 19 | 2022-01-11 | George Washington (104) | 57 | 84 | Virginia Commonwealth (38) | Final | W | 27 |
| 20 | 2022-01-14 | Virginia Commonwealth (60) | 53 | 73 | St. Bonaventure (74) | Final | L | -20 |
| 21 | 2022-01-18 | Davidson (111) | 63 | 61 | Virginia Commonwealth (38) | Final | L | -2 |
| 22 | 2022-01-22 | Saint Joseph's (99) | 54 | 70 | Virginia Commonwealth (38) | Final | W | 16 |
| 23 | 2022-01-26 | Virginia Commonwealth (66) | 70 | 68 | Davidson (27) | Final | W | 2 |
| 24 | 2022-01-29 | Virginia Commonwealth (38) | 64 | 62 | Richmond (166) | Final | W | 2 |
| 25 | 2022-02-02 | Dayton (75) | 82 | 52 | Virginia Commonwealth (51) | Final | L | -30 |
| 26 | 2022-02-05 | Duquesne (121) | 62 | 71 | Virginia Commonwealth (38) | Final | W | 9 |
| 27 | 2022-02-08 | Rhode Island (140) | 64 | 73 | Virginia Commonwealth (62) | Final | W | 9 |
| 28 | 2022-02-12 | Virginia Commonwealth (38) | 85 | 70 | George Mason (86) | Final | W | 15 |
| 29 | 2022-02-15 | Virginia Commonwealth (56) | 66 | 61 | Fordham (191) | Final | W | 5 |
| 30 | 2022-02-18 | Richmond (89) | 57 | 77 | Virginia Commonwealth (56) | Final | W | 20 |
| 31 | 2022-02-23 | George Mason (123) | 66 | 72 | Virginia Commonwealth (47) | Final | W | 6 |
| 32 | 2022-02-26 | Virginia Commonwealth (47) | 77 | 62 | Massachusetts (167) | Final | W | 15 |
| 33 | 2022-03-01 | St. Bonaventure (54) | 51 | 74 | Virginia Commonwealth (43) | Final | W | 23 |
| 34 | 2022-03-05 | Virginia Commonwealth (43) | 65 | 69 | Saint Louis (64) | Final | L | -4 |
| 35 | 2022-03-11 | Richmond (89) | 75 | 64 | Virginia Commonwealth (46) | Final | L | -11 |
| 36 | 2022-03-15 | Princeton (101) | 79 | 90 | Virginia Commonwealth (51) | Final | W | 11 |
| 37 | 2022-03-19 | Virginia Commonwealth (51) | 74 | 80 | Wake Forest (48) | Final | L | -6 |