Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Rivier | 55 | 91 | UMass-Lowell (214) | Final | W | 36 |
| 2 | 2021-11-13 | UMass-Lowell (214) | 59 | 58 | Dayton (89) | Final | W | 1 |
| 3 | 2021-11-16 | UMass-Lowell (93) | 58 | 80 | Oklahoma State (131) | Final | L | -22 |
| 4 | 2021-11-17 | Central Connecticut State (258) | 53 | 77 | UMass-Lowell (319) | Final | W | 24 |
| 5 | 2021-11-19 | UMass-Lowell (319) | 67 | 56 | George Washington (104) | Final | W | 11 |
| 6 | 2021-11-24 | UMass-Lowell (319) | 81 | 92 | Massachusetts (182) | Final | L | -11 |
| 7 | 2021-11-27 | Fisher College | 38 | 101 | UMass-Lowell (138) | Final | W | 63 |
| 8 | 2021-12-01 | Brown (295) | 73 | 63 | UMass-Lowell (319) | Final | L | -10 |
| 9 | 2021-12-04 | UMass-Lowell (319) | 61 | 57 | Merrimack (134) | Final | W | 4 |
| 10 | 2021-12-08 | UMass-Lowell (149) | 62 | 72 | Boston University (161) | Final | L | -10 |
| 11 | 2021-12-11 | MCLA | 45 | 109 | UMass-Lowell (319) | Final | W | 64 |
| 12 | 2021-12-19 | Sacred Heart (270) | 62 | 70 | UMass-Lowell (319) | Final | W | 8 |
| 13 | 2021-12-21 | UMass-Lowell (319) | 0 | 0 | Long Island (175) | Cancelled | - | - |
| 14 | 2021-12-23 | St. Francis (NY) | 0 | 0 | UMass-Lowell (319) | Cancelled | - | - |
| 15 | 2022-01-02 | UMass-Lowell (319) | 63 | 68 | Binghamton (359) | Final | L | -5 |
| 16 | 2022-01-06 | NJIT (306) | 77 | 72 | UMass-Lowell (319) | Final | L | -5 |
| 17 | 2022-01-08 | UMass-Lowell (319) | 66 | 64 | UMBC (198) | Final | W | 2 |
| 18 | 2022-01-12 | UMass-Lowell (200) | 47 | 57 | Albany (313) | Final | L | -10 |
| 19 | 2022-01-15 | Hartford | 0 | 0 | UMass-Lowell (319) | Postponed | - | - |
| 20 | 2022-01-19 | Maine (350) | 62 | 71 | UMass-Lowell (319) | Final | W | 9 |
| 21 | 2022-01-22 | UMass-Lowell (319) | 61 | 67 | New Hampshire (346) | Final | L | -6 |
| 22 | 2022-01-26 | Albany (279) | 64 | 62 | UMass-Lowell (244) | Final (OT) | L | -2 |
| 23 | 2022-01-29 | UMass-Lowell (319) | 0 | 0 | Hartford | Postponed | - | - |
| 24 | 2022-02-02 | UMass-Lowell (259) | 62 | 50 | Maine (354) | Final | W | 12 |
| 25 | 2022-02-05 | Vermont (225) | 78 | 67 | UMass-Lowell (319) | Final | L | -11 |
| 26 | 2022-02-07 | Hartford | 75 | 85 | UMass-Lowell (319) | Final | W | 10 |
| 27 | 2022-02-09 | UMass-Lowell (319) | 85 | 87 | Stony Brook (213) | Final | L | -2 |
| 28 | 2022-02-12 | UMBC (198) | 71 | 88 | UMass-Lowell (319) | Final | W | 17 |
| 29 | 2022-02-16 | UMass-Lowell (244) | 55 | 59 | NJIT (289) | Final | L | -4 |
| 30 | 2022-02-19 | Binghamton (285) | 78 | 64 | UMass-Lowell (244) | Final | L | -14 |
| 31 | 2022-02-23 | Stony Brook (216) | 50 | 67 | UMass-Lowell (259) | Final | W | 17 |
| 32 | 2022-02-26 | UMass-Lowell (259) | 61 | 62 | Vermont (83) | Final | L | -1 |
| 33 | 2022-03-01 | New Hampshire (240) | 64 | 48 | UMass-Lowell (255) | Final | L | -16 |
| 34 | 2022-03-03 | UMass-Lowell (255) | 83 | 73 | Hartford (294) | Final | W | 10 |
| 35 | 2022-03-06 | UMass-Lowell (260) | 85 | 93 | UMBC (220) | Final | L | -8 |