Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-24 | Georgia (92) | 65 | 76 | Charlotte (259) | Final | W | 11 |
| 2 | 2021-11-09 | Monmouth (176) | 66 | 68 | Charlotte (259) | Final | W | 2 |
| 3 | 2021-11-12 | South Carolina Upstate (293) | 64 | 76 | Charlotte (173) | Final | W | 12 |
| 4 | 2021-11-18 | Charlotte (61) | 67 | 66 | Appalachian State (198) | Final | W | 1 |
| 5 | 2021-11-22 | Charlotte (173) | 86 | 98 | Toledo (135) | Final | L | -12 |
| 6 | 2021-11-23 | Drexel (189) | 67 | 55 | Charlotte (48) | Final | L | -12 |
| 7 | 2021-11-30 | Davidson (80) | 75 | 58 | Charlotte (139) | Final | L | -17 |
| 8 | 2021-12-04 | George Washington (104) | 79 | 86 | Charlotte (173) | Final | W | 7 |
| 9 | 2021-12-07 | Charlotte (173) | 66 | 86 | Arkansas (16) | Final | L | -20 |
| 10 | 2021-12-11 | Charlotte (173) | 68 | 67 | Valparaiso (156) | Final | W | 1 |
| 11 | 2021-12-17 | Wake Forest (70) | 82 | 79 | Charlotte (173) | Final | L | -3 |
| 12 | 2021-12-20 | Maryland-Eastern Shore (353) | 54 | 70 | Charlotte (173) | Final | W | 16 |
| 13 | 2021-12-22 | Western Carolina (223) | 82 | 98 | Charlotte (173) | Final | W | 16 |
| 14 | 2021-12-30 | Charlotte (173) | 0 | 0 | Florida Atlantic (128) | Postponed | - | - |
| 15 | 2022-01-08 | Longwood (269) | 0 | 0 | Charlotte (173) | Canceled | - | - |
| 16 | 2022-01-13 | UTEP (274) | 53 | 66 | Charlotte (173) | Final | W | 13 |
| 17 | 2022-01-15 | UTSA (344) | 53 | 62 | Charlotte (173) | Final | W | 9 |
| 18 | 2022-01-17 | Charlotte (116) | 67 | 96 | Florida Atlantic (243) | Final | L | -29 |
| 19 | 2022-01-20 | Charlotte (173) | 51 | 65 | North Texas (125) | Final | L | -14 |
| 20 | 2022-01-22 | Charlotte (173) | 67 | 64 | Rice (228) | Final | W | 3 |
| 21 | 2022-01-26 | Old Dominion (231) | 67 | 71 | Charlotte (131) | Final | W | 4 |
| 22 | 2022-01-29 | Charlotte (173) | 52 | 68 | Old Dominion (254) | Final | L | -16 |
| 23 | 2022-02-03 | Western Kentucky (154) | 78 | 59 | Charlotte (173) | Final | L | -19 |
| 24 | 2022-02-05 | Marshall (155) | 64 | 88 | Charlotte (173) | Final | W | 24 |
| 25 | 2022-02-07 | Charlotte (173) | 81 | 68 | Florida International (214) | Final | W | 13 |
| 26 | 2022-02-10 | Louisiana Tech (185) | 82 | 77 | Charlotte (173) | Final | L | -5 |
| 27 | 2022-02-13 | Charlotte (149) | 63 | 78 | Middle Tennessee (106) | Final | L | -15 |
| 28 | 2022-02-17 | Charlotte (173) | 67 | 77 | Western Kentucky (154) | Final | L | -10 |
| 29 | 2022-02-19 | Charlotte (149) | 99 | 84 | Marshall (246) | Final | W | 15 |
| 30 | 2022-02-24 | Florida International (203) | 55 | 64 | Charlotte (150) | Final | W | 9 |
| 31 | 2022-02-26 | Florida Atlantic (168) | 74 | 69 | Charlotte (150) | Final | L | -5 |
| 32 | 2022-03-02 | Middle Tennessee (90) | 56 | 60 | Charlotte (149) | Final | W | 4 |
| 33 | 2022-03-05 | Charlotte (149) | 70 | 67 | Southern Miss (336) | Final | W | 3 |
| 34 | 2022-03-09 | Rice (209) | 73 | 61 | Charlotte (147) | Final | L | -12 |