Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Johnson & Wales (NC) | 71 | 118 | Charleston Southern (339) | Final | W | 47 |
| 2 | 2021-11-12 | Charleston Southern (262) | 68 | 93 | Ole Miss (79) | Final | L | -25 |
| 3 | 2021-11-17 | Charleston Southern (262) | 59 | 95 | Wake Forest (70) | Final | L | -36 |
| 4 | 2021-11-20 | Bob Jones | 63 | 119 | Charleston Southern (262) | Final | W | 56 |
| 5 | 2021-11-22 | Charleston Southern (262) | 70 | 85 | Georgia Tech (158) | Final | L | -15 |
| 6 | 2021-11-26 | Charleston Southern (262) | 59 | 91 | Clemson (36) | Final | L | -32 |
| 7 | 2021-11-28 | Charleston Southern (323) | 52 | 89 | Kennesaw State (217) | Final | L | -37 |
| 8 | 2021-12-02 | Jacksonville (209) | 67 | 56 | Charleston Southern (323) | Final | L | -11 |
| 9 | 2021-12-05 | Charleston Southern (323) | 59 | 57 | Tarleton State (307) | Final | W | 2 |
| 10 | 2021-12-16 | Tennessee State (165) | 78 | 75 | Charleston Southern (262) | Final | L | -3 |
| 11 | 2021-12-20 | Manhattan (307) | 99 | 75 | Charleston Southern (262) | Final | L | -24 |
| 12 | 2021-12-21 | South Carolina State (355) | 75 | 65 | Charleston Southern (262) | Final | L | -10 |
| 13 | 2022-01-02 | Toccoa Falls | 0 | 0 | Charleston Southern (262) | Postponed | - | - |
| 14 | 2022-01-05 | Gardner-Webb (363) | 88 | 63 | Charleston Southern (262) | Final | L | -25 |
| 15 | 2022-01-08 | Charleston Southern (262) | 59 | 82 | UNC-Asheville (244) | Final | L | -23 |
| 16 | 2022-01-12 | Charleston Southern (340) | 52 | 67 | Campbell (222) | Final | L | -15 |
| 17 | 2022-01-15 | Winthrop (133) | 70 | 65 | Charleston Southern (262) | Final | L | -5 |
| 18 | 2022-01-19 | High Point (69) | 66 | 70 | Charleston Southern (262) | Final | W | 4 |
| 19 | 2022-01-22 | Charleston Southern (262) | 57 | 70 | South Carolina Upstate (293) | Final | L | -13 |
| 20 | 2022-01-26 | Presbyterian (258) | 62 | 61 | Charleston Southern (339) | Final | L | -1 |
| 21 | 2022-01-29 | Hampton (260) | 78 | 74 | Charleston Southern (262) | Final | L | -4 |
| 22 | 2022-02-02 | Charleston Southern (342) | 52 | 64 | Radford (305) | Final | L | -12 |
| 23 | 2022-02-05 | Longwood (269) | 69 | 67 | Charleston Southern (262) | Final | L | -2 |
| 24 | 2022-02-07 | Toccoa Falls | 60 | 97 | Charleston Southern (262) | Final | W | 37 |
| 25 | 2022-02-09 | Charleston Southern (262) | 51 | 62 | North Carolina A&T (294) | Final | L | -11 |
| 26 | 2022-02-12 | Charleston Southern (262) | 65 | 82 | Gardner-Webb (363) | Final | L | -17 |
| 27 | 2022-02-16 | UNC-Asheville (214) | 85 | 66 | Charleston Southern (345) | Final | L | -19 |
| 28 | 2022-02-19 | South Carolina Upstate (261) | 78 | 73 | Charleston Southern (345) | Final | L | -5 |
| 29 | 2022-02-23 | Charleston Southern (347) | 48 | 68 | Presbyterian (263) | Final | L | -20 |
| 30 | 2022-02-26 | Charleston Southern (347) | 86 | 92 | Winthrop (145) | Final | L | -6 |
| 31 | 2022-03-02 | Charleston Southern (348) | 79 | 78 | UNC-Asheville (219) | Final | W | 1 |
| 32 | 2022-03-04 | Charleston Southern (348) | 62 | 72 | South Carolina Upstate (246) | Final | L | -10 |