Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | Western Carolina (246) | 66 | 85 | Charleston (223) | Final | L | -19 |
| 2 | 2021-11-01 | Campbellsville - Harrodsburg | 62 | 106 | Western Carolina (246) | Final | W | 44 |
| 3 | 2021-11-09 | Bowling Green (154) | 71 | 79 | Western Carolina (246) | Final (OT) | W | 8 |
| 4 | 2021-11-12 | Western Carolina (223) | 75 | 87 | Wake Forest (70) | Final | L | -12 |
| 5 | 2021-11-14 | Western Carolina (223) | 79 | 95 | East Carolina (252) | Final | L | -16 |
| 6 | 2021-11-19 | UMBC (198) | 91 | 75 | Western Carolina (223) | Final | L | -16 |
| 7 | 2021-11-20 | Western Carolina (223) | 80 | 79 | American (249) | Final | W | 1 |
| 8 | 2021-11-20 | American (66) | 0 | 0 | Western Carolina (215) | Cancelled | - | - |
| 9 | 2021-11-21 | Western Carolina (224) | 64 | 53 | Longwood (149) | Final | W | 11 |
| 10 | 2021-11-27 | Western Carolina (224) | 59 | 87 | Gardner-Webb (259) | Final | L | -28 |
| 11 | 2021-12-01 | Warren Wilson | 47 | 102 | Western Carolina (223) | Final | W | 55 |
| 12 | 2021-12-04 | Western Carolina (223) | 78 | 73 | South Carolina Upstate (293) | Final | W | 5 |
| 13 | 2021-12-08 | Tennessee Tech (267) | 69 | 74 | Western Carolina (212) | Final (OT) | W | 5 |
| 14 | 2021-12-11 | UNC-Asheville (244) | 73 | 72 | Western Carolina (223) | Final | L | -1 |
| 15 | 2021-12-20 | Western Carolina (223) | 79 | 85 | Georgia (35) | Final | L | -6 |
| 16 | 2021-12-22 | Western Carolina (223) | 82 | 98 | Charlotte (173) | Final | L | -16 |
| 17 | 2021-12-29 | UNC-Greensboro (265) | 0 | 0 | Western Carolina (223) | Postponed | - | - |
| 18 | 2022-01-01 | Western Carolina (223) | 0 | 0 | East Tennessee State (140) | Postponed | - | - |
| 19 | 2022-01-05 | The Citadel (332) | 90 | 94 | Western Carolina (223) | Final/OT | W | 4 |
| 20 | 2022-01-08 | Western Carolina (223) | 60 | 85 | Samford (203) | Final | L | -25 |
| 21 | 2022-01-10 | Western Carolina (256) | 69 | 87 | East Tennessee State (146) | Final | L | -18 |
| 22 | 2022-01-12 | Chattanooga (48) | 59 | 70 | Western Carolina (256) | Final | W | 11 |
| 23 | 2022-01-15 | Wofford (221) | 84 | 64 | Western Carolina (223) | Final | L | -20 |
| 24 | 2022-01-19 | Western Carolina (223) | 50 | 88 | Furman (157) | Final | L | -38 |
| 25 | 2022-01-22 | Western Carolina (223) | 64 | 72 | Mercer (174) | Final | L | -8 |
| 26 | 2022-01-26 | Western Carolina (264) | 66 | 68 | The Citadel (249) | Final | L | -2 |
| 27 | 2022-01-29 | Samford (203) | 74 | 64 | Western Carolina (223) | Final | L | -10 |
| 28 | 2022-02-02 | East Tennessee State (158) | 84 | 87 | Western Carolina (270) | Final | W | 3 |
| 29 | 2022-02-04 | Western Carolina (270) | 69 | 76 | Virginia Military (169) | Final | L | -7 |
| 30 | 2022-02-07 | UNC-Greensboro (265) | 68 | 49 | Western Carolina (223) | Final | L | -19 |
| 31 | 2022-02-09 | Western Carolina (223) | 47 | 65 | Chattanooga (291) | Final | L | -18 |
| 32 | 2022-02-12 | Western Carolina (223) | 57 | 69 | Wofford (221) | Final | L | -12 |
| 33 | 2022-02-16 | Furman (100) | 103 | 85 | Western Carolina (274) | Final | L | -18 |
| 34 | 2022-02-19 | Mercer (175) | 65 | 69 | Western Carolina (274) | Final | W | 4 |
| 35 | 2022-02-23 | Western Carolina (266) | 64 | 73 | UNC-Greensboro (159) | Final | L | -9 |
| 36 | 2022-02-26 | Virginia Military (146) | 73 | 82 | Western Carolina (266) | Final | W | 9 |
| 37 | 2022-03-04 | Western Carolina (258) | 53 | 81 | Mercer (194) | Final | L | -28 |