Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Towson (290) | 77 | 56 | Albany (218) | Final | W | 21 |
| 2 | 2021-11-13 | Monmouth (176) | 79 | 71 | Towson (290) | Final | L | -8 |
| 3 | 2021-11-16 | Hampton (169) | 54 | 78 | Towson (203) | Final | W | 24 |
| 4 | 2021-11-19 | Towson (152) | 59 | 63 | Pittsburgh (108) | Final | L | -4 |
| 5 | 2021-11-23 | Penn (202) | 61 | 76 | Towson (201) | Final | W | 15 |
| 6 | 2021-11-25 | San Francisco (122) | 71 | 61 | Towson (152) | Final | L | -10 |
| 7 | 2021-11-26 | Towson (152) | 73 | 58 | New Mexico (49) | Final | W | 15 |
| 8 | 2021-12-02 | Long Island (306) | 63 | 72 | Towson (128) | Final | W | 9 |
| 9 | 2021-12-06 | Towson (125) | 73 | 58 | Kent State (121) | Final | W | 15 |
| 10 | 2021-12-08 | Towson (125) | 74 | 85 | Ohio State (29) | Final | L | -11 |
| 11 | 2021-12-11 | Towson (152) | 89 | 75 | Coppin State (360) | Final | W | 14 |
| 12 | 2021-12-14 | UNC-Greensboro (265) | 64 | 74 | Towson (152) | Final | W | 10 |
| 13 | 2021-12-22 | Towson (152) | 69 | 52 | Navy (149) | Final | W | 17 |
| 14 | 2021-12-31 | James Madison (202) | 0 | 0 | Towson (152) | Postponed | - | - |
| 15 | 2022-01-03 | Towson (152) | 61 | 65 | Drexel (215) | Final | L | -4 |
| 16 | 2022-01-05 | Towson (152) | 0 | 0 | Delaware (287) | Postponed | - | - |
| 17 | 2022-01-09 | Northeastern (236) | 67 | 70 | Towson (103) | Final | W | 3 |
| 18 | 2022-01-11 | Hofstra (98) | 66 | 78 | Towson (152) | Final | W | 12 |
| 19 | 2022-01-15 | Towson (152) | 59 | 54 | Elon (232) | Final | W | 5 |
| 20 | 2022-01-17 | Towson (98) | 91 | 69 | William & Mary (336) | Final | W | 22 |
| 21 | 2022-01-20 | Charleston (123) | 67 | 74 | Towson (152) | Final | W | 7 |
| 22 | 2022-01-22 | UNC-Wilmington (90) | 81 | 77 | Towson (152) | Final/OT | L | -4 |
| 23 | 2022-01-24 | Towson (152) | 69 | 62 | Delaware (287) | Final | W | 7 |
| 24 | 2022-01-27 | Delaware (287) | 0 | 0 | Towson (152) | Suspended | - | - |
| 25 | 2022-01-29 | Drexel (215) | 62 | 66 | Towson (152) | Final | W | 4 |
| 26 | 2022-02-03 | Towson (152) | 78 | 68 | Hofstra (98) | Final | W | 10 |
| 27 | 2022-02-05 | Towson (152) | 53 | 58 | Northeastern (300) | Final | L | -5 |
| 28 | 2022-02-10 | William & Mary (141) | 60 | 75 | Towson (152) | Final | W | 15 |
| 29 | 2022-02-12 | Elon (232) | 50 | 86 | Towson (152) | Final | W | 36 |
| 30 | 2022-02-17 | Towson (152) | 79 | 55 | UNC-Wilmington (90) | Final | W | 24 |
| 31 | 2022-02-19 | Towson (98) | 80 | 77 | Charleston (151) | Final | W | 3 |
| 32 | 2022-02-23 | James Madison (170) | 65 | 84 | Towson (88) | Final | W | 19 |
| 33 | 2022-02-26 | Towson (88) | 95 | 59 | James Madison (170) | Final | W | 36 |
| 34 | 2022-02-28 | Delaware (127) | 57 | 69 | Towson (81) | Final | W | 12 |
| 35 | 2022-03-06 | Northeastern (265) | 61 | 68 | Towson (75) | Final | W | 7 |
| 36 | 2022-03-07 | Delaware (134) | 69 | 56 | Towson (75) | Final | L | -13 |
| 37 | 2022-03-16 | Towson (152) | 64 | 74 | Wake Forest (70) | Final | L | -10 |