Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | South Carolina Upstate (335) | 60 | 78 | South Carolina (151) | Final | L | -18 |
| 2 | 2021-11-12 | South Carolina Upstate (293) | 64 | 76 | Charlotte (173) | Final | L | -12 |
| 3 | 2021-11-15 | St. Andrews | 43 | 96 | South Carolina Upstate (310) | Final | W | 53 |
| 4 | 2021-11-18 | South Carolina Upstate (310) | 43 | 56 | East Tennessee State (325) | Final | L | -13 |
| 5 | 2021-11-23 | South Carolina Upstate (300) | 82 | 78 | South Carolina State (354) | Final | W | 4 |
| 6 | 2021-11-27 | Furman (150) | 87 | 77 | South Carolina Upstate (300) | Final | L | -10 |
| 7 | 2021-12-01 | North Carolina Central (341) | 67 | 65 | South Carolina Upstate (293) | Final | L | -2 |
| 8 | 2021-12-04 | Western Carolina (223) | 78 | 73 | South Carolina Upstate (293) | Final | L | -5 |
| 9 | 2021-12-11 | South Carolina Upstate (293) | 53 | 79 | Wake Forest (70) | Final | L | -26 |
| 10 | 2021-12-14 | South Carolina Upstate (293) | 52 | 96 | Tennessee (18) | Final | L | -44 |
| 11 | 2021-12-18 | Converse | 38 | 78 | South Carolina Upstate (293) | Final | W | 40 |
| 12 | 2021-12-18 | Brevard | 0 | 0 | South Carolina Upstate | Cancelled | - | - |
| 13 | 2021-12-21 | South Carolina Upstate (293) | 70 | 85 | Ohio (218) | Final | L | -15 |
| 14 | 2021-12-30 | Columbia International | 0 | 0 | South Carolina Upstate (293) | Cancelled | - | - |
| 15 | 2022-01-06 | Radford (255) | 82 | 77 | South Carolina Upstate (293) | Final | L | -5 |
| 16 | 2022-01-08 | South Carolina Upstate (293) | 82 | 72 | Presbyterian (264) | Final | W | 10 |
| 17 | 2022-01-12 | High Point (277) | 65 | 66 | South Carolina Upstate (299) | Final | W | 1 |
| 18 | 2022-01-15 | South Carolina Upstate (293) | 76 | 73 | UNC-Asheville (244) | Final | W | 3 |
| 19 | 2022-01-19 | South Carolina Upstate (293) | 74 | 61 | Gardner-Webb (363) | Final | W | 13 |
| 20 | 2022-01-22 | Charleston Southern (262) | 57 | 70 | South Carolina Upstate (293) | Final | W | 13 |
| 21 | 2022-01-26 | Winthrop (154) | 95 | 91 | South Carolina Upstate (252) | Final (OT) | L | -4 |
| 22 | 2022-01-29 | South Carolina Upstate (293) | 84 | 64 | North Carolina A&T (294) | Final | W | 20 |
| 23 | 2022-02-02 | South Carolina Upstate (248) | 85 | 78 | Hampton (336) | Final | W | 7 |
| 24 | 2022-02-05 | Campbell (191) | 80 | 71 | South Carolina Upstate (293) | Final | L | -9 |
| 25 | 2022-02-10 | South Carolina Upstate (293) | 72 | 85 | Longwood (269) | Final | L | -13 |
| 26 | 2022-02-12 | UNC-Asheville (244) | 83 | 56 | South Carolina Upstate (293) | Final | L | -27 |
| 27 | 2022-02-16 | Presbyterian (257) | 55 | 60 | South Carolina Upstate (261) | Final | W | 5 |
| 28 | 2022-02-19 | South Carolina Upstate (261) | 78 | 73 | Charleston Southern (345) | Final | W | 5 |
| 29 | 2022-02-24 | South Carolina Upstate (247) | 59 | 89 | Winthrop (145) | Final | L | -30 |
| 30 | 2022-02-26 | Gardner-Webb (189) | 70 | 72 | South Carolina Upstate (247) | Final | W | 2 |
| 31 | 2022-03-04 | Charleston Southern (348) | 62 | 72 | South Carolina Upstate (246) | Final | W | 10 |
| 32 | 2022-03-05 | South Carolina Upstate (246) | 70 | 79 | Longwood (132) | Final | L | -9 |
| 33 | 2022-03-15 | South Carolina Upstate (251) | 80 | 74 | Appalachian State (145) | Final | W | 6 |
| 34 | 2022-03-21 | South Carolina Upstate (251) | 79 | 83 | South Alabama (156) | Final | L | -4 |