Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | North Carolina A&T (289) | 53 | 57 | UNC-Greensboro (93) | Final | L | -4 |
| 2 | 2021-11-13 | North Carolina A&T (289) | 54 | 63 | Jacksonville (282) | Final | L | -9 |
| 3 | 2021-11-15 | North Carolina A&T (297) | 54 | 56 | South Florida (166) | Final | L | -2 |
| 4 | 2021-11-18 | Greensboro | 69 | 77 | North Carolina A&T (297) | Final | W | 8 |
| 5 | 2021-11-20 | North Carolina A&T (294) | 63 | 87 | Wake Forest (70) | Final | L | -24 |
| 6 | 2021-11-23 | North Carolina A&T (330) | 65 | 79 | Stanford (142) | Final | L | -14 |
| 7 | 2021-11-26 | Samford (203) | 77 | 75 | North Carolina A&T (294) | Final | L | -2 |
| 8 | 2021-11-27 | St. Francis (NY) (344) | 67 | 73 | North Carolina A&T (330) | Final | W | 6 |
| 9 | 2021-12-03 | Carver Bible | 55 | 97 | North Carolina A&T (322) | Final | W | 42 |
| 10 | 2021-12-07 | North Carolina A&T (294) | 71 | 82 | East Carolina (252) | Final | L | -11 |
| 11 | 2021-12-11 | North Carolina A&T (294) | 68 | 83 | Central Florida (43) | Final | L | -15 |
| 12 | 2021-12-14 | North Carolina A&T (294) | 69 | 67 | East Tennessee State (140) | Final | W | 2 |
| 13 | 2021-12-18 | North Carolina A&T (294) | 57 | 79 | Howard (211) | Final | L | -22 |
| 14 | 2021-12-21 | Mid-Atlantic | 63 | 88 | North Carolina A&T (296) | Final | W | 25 |
| 15 | 2022-01-05 | Presbyterian (264) | 57 | 65 | North Carolina A&T (294) | Final | W | 8 |
| 16 | 2022-01-08 | North Carolina A&T (294) | 73 | 72 | Radford (255) | Final | W | 1 |
| 17 | 2022-01-12 | Hampton (319) | 59 | 67 | North Carolina A&T (273) | Final | W | 8 |
| 18 | 2022-01-15 | North Carolina A&T (294) | 71 | 78 | High Point (69) | Final | L | -7 |
| 19 | 2022-01-19 | North Carolina A&T (294) | 73 | 71 | UNC-Asheville (244) | Final | W | 2 |
| 20 | 2022-01-22 | Campbell (191) | 73 | 72 | North Carolina A&T (294) | Final | L | -1 |
| 21 | 2022-01-26 | North Carolina A&T (276) | 71 | 79 | Longwood (162) | Final | L | -8 |
| 22 | 2022-01-29 | South Carolina Upstate (293) | 84 | 64 | North Carolina A&T (294) | Final | L | -20 |
| 23 | 2022-02-03 | North Carolina A&T (294) | 54 | 64 | Winthrop (133) | Final | L | -10 |
| 24 | 2022-02-05 | North Carolina A&T (294) | 62 | 69 | Gardner-Webb (363) | Final | L | -7 |
| 25 | 2022-02-09 | Charleston Southern (262) | 51 | 62 | North Carolina A&T (294) | Final | W | 11 |
| 26 | 2022-02-12 | Longwood (269) | 62 | 70 | North Carolina A&T (294) | Final | W | 8 |
| 27 | 2022-02-16 | North Carolina A&T (278) | 82 | 93 | Hampton (340) | Final | L | -11 |
| 28 | 2022-02-19 | North Carolina A&T (278) | 63 | 64 | Campbell (210) | Final | L | -1 |
| 29 | 2022-02-23 | High Point (264) | 78 | 58 | North Carolina A&T (290) | Final | L | -20 |
| 30 | 2022-02-26 | Radford (287) | 62 | 53 | North Carolina A&T (290) | Final | L | -9 |
| 31 | 2022-03-02 | North Carolina A&T (299) | 78 | 71 | Radford (284) | Final | W | 7 |
| 32 | 2022-03-04 | North Carolina A&T (299) | 65 | 79 | Longwood (132) | Final | L | -14 |