Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | William & Mary (265) | 59 | 77 | Wake Forest (203) | Final | L | -18 |
| 2 | 2021-11-12 | American (249) | 74 | 62 | William & Mary (141) | Final | L | -12 |
| 3 | 2021-11-16 | William & Mary (292) | 74 | 91 | Norfolk State (113) | Final | L | -17 |
| 4 | 2021-11-20 | Georgia State (299) | 77 | 59 | William & Mary (141) | Final | L | -18 |
| 5 | 2021-11-21 | Howard (211) | 82 | 76 | William & Mary (352) | Final | L | -6 |
| 6 | 2021-11-24 | William & Mary (141) | 54 | 67 | Radford (255) | Final | L | -13 |
| 7 | 2021-11-27 | Mary Baldwin | 50 | 87 | William & Mary (352) | Final | W | 37 |
| 8 | 2021-12-01 | William & Mary (141) | 56 | 75 | Navy (149) | Final | L | -19 |
| 9 | 2021-12-04 | William & Mary (141) | 46 | 70 | Davidson (111) | Final | L | -24 |
| 10 | 2021-12-07 | Old Dominion (254) | 74 | 59 | William & Mary (141) | Final | L | -15 |
| 11 | 2021-12-09 | Hampton (312) | 54 | 53 | William & Mary (346) | Final | L | -1 |
| 12 | 2021-12-12 | Fairfield (204) | 70 | 47 | William & Mary (141) | Final | L | -23 |
| 13 | 2021-12-22 | William & Mary (141) | 66 | 88 | Valparaiso (156) | Final | L | -22 |
| 14 | 2021-12-29 | Hofstra (98) | 62 | 63 | William & Mary (141) | Final | W | 1 |
| 15 | 2021-12-31 | Northeastern (300) | 70 | 71 | William & Mary (141) | Final | W | 1 |
| 16 | 2022-01-11 | William & Mary (141) | 0 | 0 | Charleston (123) | Postponed | - | - |
| 17 | 2022-01-15 | James Madison (202) | 95 | 91 | William & Mary (141) | Final/OT | L | -4 |
| 18 | 2022-01-17 | Towson (98) | 91 | 69 | William & Mary (336) | Final | L | -22 |
| 19 | 2022-01-20 | William & Mary (141) | 74 | 84 | Delaware (287) | Final | L | -10 |
| 20 | 2022-01-22 | William & Mary (141) | 83 | 75 | Drexel (215) | Final | W | 8 |
| 21 | 2022-01-25 | William & Mary (331) | 73 | 74 | Charleston (153) | Final | L | -1 |
| 22 | 2022-01-27 | William & Mary (141) | 54 | 61 | Elon (232) | Final | L | -7 |
| 23 | 2022-01-29 | Elon (232) | 61 | 65 | William & Mary (141) | Final | W | 4 |
| 24 | 2022-02-03 | Charleston (123) | 84 | 61 | William & Mary (141) | Final | L | -23 |
| 25 | 2022-02-05 | UNC-Wilmington (90) | 92 | 70 | William & Mary (141) | Final | L | -22 |
| 26 | 2022-02-10 | William & Mary (141) | 60 | 75 | Towson (152) | Final | L | -15 |
| 27 | 2022-02-12 | William & Mary (141) | 55 | 69 | James Madison (202) | Final | L | -14 |
| 28 | 2022-02-14 | William & Mary (141) | 73 | 80 | UNC-Wilmington (90) | Final/OT | L | -7 |
| 29 | 2022-02-17 | Drexel (215) | 72 | 57 | William & Mary (141) | Final | L | -15 |
| 30 | 2022-02-19 | Delaware (125) | 73 | 69 | William & Mary (330) | Final | L | -4 |
| 31 | 2022-02-24 | William & Mary (332) | 28 | 62 | Northeastern (261) | Final | L | -34 |
| 32 | 2022-02-26 | William & Mary (332) | 67 | 83 | Hofstra (100) | Final | L | -16 |
| 33 | 2022-03-05 | Northeastern (264) | 68 | 63 | William & Mary (340) | Final | L | -5 |