Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Maryland-Eastern Shore | 49 | 72 | Temple (166) | Final | W | 23 |
| 2 | 2021-11-13 | USC (16) | 76 | 71 | Temple (166) | Final | L | -5 |
| 3 | 2021-11-18 | Clemson (38) | 75 | 48 | Temple (136) | Final | L | -27 |
| 4 | 2021-11-19 | Boise State (62) | 82 | 62 | Temple (169) | Final | L | -20 |
| 5 | 2021-11-21 | Temple (174) | 75 | 58 | Elon (306) | Final | W | 17 |
| 6 | 2021-11-27 | Delaware (159) | 74 | 75 | Temple (174) | Final | W | 1 |
| 7 | 2021-12-01 | La Salle (237) | 57 | 73 | Temple (169) | Final | W | 16 |
| 8 | 2021-12-04 | Penn (131) | 72 | 81 | Temple (169) | Final | W | 9 |
| 9 | 2021-12-07 | Temple (169) | 72 | 68 | Vanderbilt (17) | Final/OT | W | 4 |
| 10 | 2021-12-11 | Temple (169) | 49 | 68 | Saint Joseph's (99) | Final | L | -19 |
| 11 | 2021-12-15 | Central Florida (43) | 65 | 48 | Temple (169) | Final | L | -17 |
| 12 | 2021-12-18 | Drexel (215) | 0 | 0 | Temple (169) | Cancelled | - | - |
| 13 | 2021-12-22 | Delaware State (361) | 48 | 85 | Temple (169) | Final | W | 37 |
| 14 | 2021-12-29 | Temple (169) | 0 | 0 | Villanova (29) | Cancelled | - | - |
| 15 | 2022-01-02 | Houston (5) | 66 | 61 | Temple (169) | Final | L | -5 |
| 16 | 2022-01-05 | Temple (169) | 66 | 62 | Central Florida (43) | Final | W | 4 |
| 17 | 2022-01-08 | East Carolina (252) | 75 | 78 | Temple (169) | Final | W | 3 |
| 18 | 2022-01-12 | Temple (97) | 69 | 64 | Tulsa (170) | Final | W | 5 |
| 19 | 2022-01-19 | Wichita State (76) | 0 | 0 | Temple (169) | Canceled | - | - |
| 20 | 2022-01-22 | Temple (169) | 0 | 0 | South Florida (52) | Postponed | - | - |
| 21 | 2022-01-25 | Cincinnati (71) | 58 | 61 | Temple (98) | Final | W | 3 |
| 22 | 2022-01-29 | Temple (169) | 61 | 69 | SMU (45) | Final | L | -8 |
| 23 | 2022-02-02 | Temple (96) | 71 | 63 | East Carolina (131) | Final | W | 8 |
| 24 | 2022-02-05 | Tulsa (55) | 58 | 67 | Temple (169) | Final | W | 9 |
| 25 | 2022-02-07 | Temple (169) | 49 | 52 | South Florida (52) | Final | L | -3 |
| 26 | 2022-02-12 | Temple (169) | 83 | 92 | Tulane (167) | Final/OT | L | -9 |
| 27 | 2022-02-16 | SMU (42) | 57 | 64 | Temple (107) | Final | W | 7 |
| 28 | 2022-02-20 | Temple (97) | 75 | 71 | Cincinnati (95) | Final | W | 4 |
| 29 | 2022-02-24 | Temple (97) | 64 | 78 | Memphis (55) | Final | L | -14 |
| 30 | 2022-02-27 | Tulane (117) | 70 | 75 | Temple (97) | Final | W | 5 |
| 31 | 2022-03-03 | Temple (97) | 46 | 84 | Houston (10) | Final | L | -38 |
| 32 | 2022-03-06 | South Florida (237) | 47 | 75 | Temple (99) | Final | W | 28 |
| 33 | 2022-03-11 | Tulane (113) | 69 | 60 | Temple (99) | Final | L | -9 |