Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Coppin State (273) | 45 | 103 | Loyola-Chicago (27) | Final | W | 58 |
| 2 | 2021-11-13 | Florida Gulf Coast (227) | 77 | 89 | Loyola-Chicago (27) | Final | W | 12 |
| 3 | 2021-11-16 | Chicago State (58) | 56 | 92 | Loyola-Chicago (40) | Final | W | 36 |
| 4 | 2021-11-20 | Illinois-Chicago (139) | 63 | 80 | Loyola-Chicago (263) | Final | W | 17 |
| 5 | 2021-11-24 | Loyola-Chicago (263) | 61 | 63 | Michigan State (10) | Final | L | -2 |
| 6 | 2021-11-25 | Auburn (37) | 62 | 53 | Loyola-Chicago (263) | Final | L | -9 |
| 7 | 2021-11-26 | Arizona State (61) | 59 | 77 | Loyola-Chicago (263) | Final | W | 18 |
| 8 | 2021-12-01 | Indiana State (243) | 76 | 88 | Loyola-Chicago (263) | Final | W | 12 |
| 9 | 2021-12-04 | Loyola-Chicago (263) | 68 | 64 | DePaul (95) | Final | W | 4 |
| 10 | 2021-12-07 | Roosevelt | 49 | 88 | Loyola-Chicago (263) | Final | W | 39 |
| 11 | 2021-12-10 | Loyola-Chicago (34) | 69 | 58 | Vanderbilt (100) | Final | W | 11 |
| 12 | 2021-12-19 | Norfolk State (322) | 0 | 0 | Loyola-Chicago (263) | Cancelled | - | - |
| 13 | 2021-12-22 | Loyola-Chicago | 0 | 0 | Davidson | Cancelled | - | - |
| 14 | 2022-01-02 | St. Xavier | 0 | 0 | Loyola-Chicago (263) | Canceled | - | - |
| 15 | 2022-01-05 | Loyola-Chicago (263) | 0 | 0 | Illinois State (94) | Postponed | - | - |
| 16 | 2022-01-06 | Loyola-Chicago (263) | 79 | 74 | San Francisco (122) | Final | W | 5 |
| 17 | 2022-01-08 | Bradley (113) | 71 | 78 | Loyola-Chicago (263) | Final/OT | W | 7 |
| 18 | 2022-01-11 | Valparaiso (156) | 74 | 81 | Loyola-Chicago (263) | Final/2OT | W | 7 |
| 19 | 2022-01-15 | Loyola-Chicago (263) | 64 | 56 | Indiana State (243) | Final | W | 8 |
| 20 | 2022-01-18 | Loyola-Chicago (263) | 77 | 48 | Evansville (302) | Final | W | 29 |
| 21 | 2022-01-22 | Missouri State (224) | 79 | 69 | Loyola-Chicago (263) | Final | L | -10 |
| 22 | 2022-01-25 | Southern Illinois (192) | 47 | 59 | Loyola-Chicago (32) | Final | W | 12 |
| 23 | 2022-01-27 | Loyola-Chicago (263) | 44 | 39 | Southern Illinois (150) | Final | W | 5 |
| 24 | 2022-01-30 | Loyola-Chicago (42) | 68 | 77 | Drake (97) | Final | L | -9 |
| 25 | 2022-02-02 | Illinois State (228) | 64 | 78 | Loyola-Chicago (42) | Final | W | 14 |
| 26 | 2022-02-06 | Loyola-Chicago (263) | 71 | 62 | Missouri State (224) | Final | W | 9 |
| 27 | 2022-02-09 | Loyola-Chicago (263) | 61 | 68 | Bradley (113) | Final | L | -7 |
| 28 | 2022-02-13 | Northern Iowa (119) | 58 | 85 | Loyola-Chicago (40) | Final | W | 27 |
| 29 | 2022-02-16 | Loyola-Chicago (40) | 71 | 69 | Valparaiso (212) | Final | W | 2 |
| 30 | 2022-02-19 | Drake (110) | 83 | 76 | Loyola-Chicago (40) | Final | L | -7 |
| 31 | 2022-02-21 | Loyola-Chicago (50) | 59 | 50 | Illinois State (254) | Final | W | 9 |
| 32 | 2022-02-23 | Evansville (318) | 31 | 82 | Loyola-Chicago (50) | Final | W | 51 |
| 33 | 2022-02-26 | Loyola-Chicago (50) | 96 | 102 | Northern Iowa (113) | Final | L | -6 |
| 34 | 2022-03-04 | Bradley (130) | 50 | 66 | Loyola-Chicago (53) | Final | W | 16 |
| 35 | 2022-03-05 | Loyola-Chicago (53) | 66 | 43 | Northern Iowa (105) | Final | W | 23 |
| 36 | 2022-03-06 | Loyola-Chicago (44) | 64 | 58 | Drake (86) | Final | W | 6 |
| 37 | 2022-03-18 | Loyola-Chicago (43) | 41 | 54 | Ohio State (34) | Final | L | -13 |