Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Mary Baldwin | 78 | 110 | Winthrop (49) | Final | W | 32 |
| 2 | 2021-11-13 | Mercer (128) | 85 | 88 | Winthrop (49) | Final (OT) | W | 3 |
| 3 | 2021-11-16 | Winthrop (118) | 65 | 76 | Middle Tennessee (110) | Final | L | -11 |
| 4 | 2021-11-20 | Winthrop (133) | 63 | 77 | Vanderbilt (17) | Final | L | -14 |
| 5 | 2021-11-22 | Winthrop (133) | 86 | 92 | Washington State (179) | Final | L | -6 |
| 6 | 2021-11-27 | Winthrop (244) | 82 | 74 | Washington (195) | Final | W | 8 |
| 7 | 2021-12-01 | Hartford | 75 | 82 | Winthrop (133) | Final | W | 7 |
| 8 | 2021-12-04 | Winthrop (133) | 64 | 74 | Coastal Carolina (188) | Final | L | -10 |
| 9 | 2021-12-07 | Furman (157) | 80 | 85 | Winthrop (133) | Final | W | 5 |
| 10 | 2021-12-11 | Winthrop (202) | 83 | 52 | Carver Bible | Final | W | 31 |
| 11 | 2021-12-15 | Winthrop (133) | 61 | 63 | Elon (232) | Final | L | -2 |
| 12 | 2021-12-21 | Winthrop (133) | 63 | 84 | Mississippi State (100) | Final | L | -21 |
| 13 | 2021-12-31 | Converse | 40 | 78 | Winthrop (133) | Final | W | 38 |
| 14 | 2022-01-05 | Winthrop (133) | 0 | 0 | High Point (69) | Postponed | - | - |
| 15 | 2022-01-10 | Campbell (222) | 72 | 74 | Winthrop (209) | Final | W | 2 |
| 16 | 2022-01-13 | UNC-Asheville (244) | 80 | 86 | Winthrop (133) | Final/OT | W | 6 |
| 17 | 2022-01-15 | Winthrop (133) | 70 | 65 | Charleston Southern (262) | Final | W | 5 |
| 18 | 2022-01-20 | Winthrop (133) | 60 | 58 | Presbyterian (264) | Final | W | 2 |
| 19 | 2022-01-22 | Gardner-Webb (363) | 62 | 64 | Winthrop (133) | Final | W | 2 |
| 20 | 2022-01-24 | Winthrop (133) | 56 | 65 | High Point (69) | Final | L | -9 |
| 21 | 2022-01-26 | Winthrop (154) | 95 | 91 | South Carolina Upstate (252) | Final (OT) | W | 4 |
| 22 | 2022-01-29 | Winthrop (133) | 88 | 92 | Longwood (269) | Final | L | -4 |
| 23 | 2022-02-03 | North Carolina A&T (294) | 54 | 64 | Winthrop (133) | Final | W | 10 |
| 24 | 2022-02-05 | Winthrop (133) | 69 | 57 | Hampton (260) | Final | W | 12 |
| 25 | 2022-02-09 | Radford (255) | 48 | 58 | Winthrop (133) | Final | W | 10 |
| 26 | 2022-02-12 | Presbyterian (264) | 61 | 65 | Winthrop (133) | Final | W | 4 |
| 27 | 2022-02-16 | Winthrop (161) | 81 | 70 | Gardner-Webb (186) | Final | W | 11 |
| 28 | 2022-02-19 | Winthrop (161) | 84 | 79 | UNC-Asheville (214) | Final | W | 5 |
| 29 | 2022-02-24 | South Carolina Upstate (247) | 59 | 89 | Winthrop (145) | Final | W | 30 |
| 30 | 2022-02-26 | Charleston Southern (347) | 86 | 92 | Winthrop (145) | Final | W | 6 |
| 31 | 2022-03-04 | High Point (256) | 51 | 68 | Winthrop (135) | Final | W | 17 |
| 32 | 2022-03-05 | Gardner-Webb (195) | 67 | 76 | Winthrop (135) | Final | W | 9 |
| 33 | 2022-03-06 | Winthrop (133) | 58 | 79 | Longwood (118) | Final | L | -21 |