Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-27 | Colorado School of Mines | 48 | 78 | Colorado (23) | Final | W | 30 |
| 2 | 2021-10-31 | Colorado (23) | 0 | 0 | Nebraska (146) | Cancelled | - | - |
| 3 | 2021-11-09 | Montana State (230) | 90 | 94 | Colorado (23) | Final (OT) | W | 4 |
| 4 | 2021-11-13 | New Mexico (296) | 76 | 87 | Colorado (23) | Final | W | 11 |
| 5 | 2021-11-15 | Maine (267) | 46 | 90 | Colorado (53) | Final | W | 44 |
| 6 | 2021-11-19 | Southern Illinois (150) | 67 | 63 | Colorado (73) | Final | L | -4 |
| 7 | 2021-11-20 | Duquesne (121) | 76 | 84 | Colorado (73) | Final/OT | W | 8 |
| 8 | 2021-11-22 | Brown (295) | 52 | 54 | Colorado (73) | Final | W | 2 |
| 9 | 2021-11-28 | Stanford (136) | 76 | 80 | Colorado (71) | Final | W | 4 |
| 10 | 2021-12-01 | Colorado (73) | 61 | 73 | UCLA (30) | Final | L | -12 |
| 11 | 2021-12-04 | Tennessee (18) | 69 | 54 | Colorado (73) | Final | L | -15 |
| 12 | 2021-12-08 | Eastern Washington (232) | 57 | 60 | Colorado (92) | Final | W | 3 |
| 13 | 2021-12-10 | Milwaukee (323) | 54 | 65 | Colorado (92) | Final | W | 11 |
| 14 | 2021-12-18 | Cal State-Bakersfield (333) | 46 | 60 | Colorado (73) | Final | W | 14 |
| 15 | 2021-12-21 | Kansas (19) | 0 | 0 | Colorado (73) | Cancelled | - | - |
| 16 | 2021-12-30 | Colorado (73) | 0 | 0 | Oregon (102) | Postponed | - | - |
| 17 | 2022-01-01 | Colorado (73) | 0 | 0 | Oregon State (144) | Postponed | - | - |
| 18 | 2022-01-03 | Colorado (73) | 0 | 0 | Oregon (102) | Postponed | - | - |
| 19 | 2022-01-06 | Washington State (179) | 78 | 83 | Colorado (73) | Final | W | 5 |
| 20 | 2022-01-09 | Washington (153) | 64 | 78 | Colorado (58) | Final | W | 14 |
| 21 | 2022-01-13 | Colorado (73) | 55 | 76 | Arizona (2) | Final | L | -21 |
| 22 | 2022-01-15 | Colorado (73) | 75 | 57 | Arizona State (61) | Final | W | 18 |
| 23 | 2022-01-20 | USC (71) | 61 | 58 | Colorado (73) | Final | L | -3 |
| 24 | 2022-01-22 | UCLA (30) | 71 | 65 | Colorado (73) | Final | L | -6 |
| 25 | 2022-01-25 | Colorado (67) | 82 | 78 | Oregon (53) | Final | W | 4 |
| 26 | 2022-01-27 | Colorado (73) | 58 | 60 | Washington (72) | Final | L | -2 |
| 27 | 2022-01-30 | Colorado (74) | 43 | 70 | Washington State (67) | Final | L | -27 |
| 28 | 2022-02-03 | Oregon (102) | 66 | 51 | Colorado (73) | Final | L | -15 |
| 29 | 2022-02-05 | Oregon State (144) | 63 | 86 | Colorado (73) | Final | W | 23 |
| 30 | 2022-02-12 | Utah (130) | 76 | 81 | Colorado (73) | Final | W | 5 |
| 31 | 2022-02-15 | Colorado (78) | 90 | 64 | Oregon State (273) | Final | W | 26 |
| 32 | 2022-02-17 | Colorado (73) | 70 | 62 | California (65) | Final | W | 8 |
| 33 | 2022-02-19 | Colorado (78) | 70 | 53 | Stanford (67) | Final | W | 17 |
| 34 | 2022-02-24 | Arizona State (110) | 82 | 65 | Colorado (66) | Final | L | -17 |
| 35 | 2022-02-26 | Arizona (2) | 63 | 79 | Colorado (66) | Final | W | 16 |
| 36 | 2022-03-05 | Colorado (61) | 84 | 71 | Utah (136) | Final | W | 13 |
| 37 | 2022-03-10 | Oregon (72) | 69 | 80 | Colorado (58) | Final | W | 11 |
| 38 | 2022-03-11 | Colorado (58) | 72 | 82 | Arizona (1) | Final | L | -10 |
| 39 | 2022-03-15 | St. Bonaventure (61) | 76 | 68 | Colorado (55) | Final | L | -8 |