Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-28 | Berea College | 63 | 104 | Tennessee Tech (323) | Final | W | 41 |
| 2 | 2021-11-09 | Tennessee Tech (323) | 65 | 89 | Memphis (48) | Final | L | -24 |
| 3 | 2021-11-14 | Oakwood | 68 | 109 | Tennessee Tech (310) | Final | W | 41 |
| 4 | 2021-11-16 | Tennessee Tech (234) | 62 | 69 | Chattanooga (56) | Final | L | -7 |
| 5 | 2021-11-18 | Tennessee Tech (234) | 55 | 61 | UNC-Asheville (277) | Final | L | -6 |
| 6 | 2021-11-23 | Lipscomb (176) | 77 | 88 | Tennessee Tech (272) | Final | W | 11 |
| 7 | 2021-11-26 | Tennessee Tech (310) | 69 | 80 | Tennessee (18) | Final | L | -11 |
| 8 | 2021-11-30 | Chattanooga (61) | 82 | 65 | Tennessee Tech (222) | Final | L | -17 |
| 9 | 2021-12-04 | Tennessee Tech (310) | 51 | 59 | Evansville (302) | Final | L | -8 |
| 10 | 2021-12-08 | Tennessee Tech (267) | 69 | 74 | Western Carolina (212) | Final (OT) | L | -5 |
| 11 | 2021-12-11 | Troy (127) | 75 | 72 | Tennessee Tech (310) | Final | L | -3 |
| 12 | 2021-12-16 | Montreat | 60 | 117 | Tennessee Tech (310) | Final | W | 57 |
| 13 | 2021-12-16 | Kentucky Christian | 0 | 0 | Tennessee Tech | Cancelled | - | - |
| 14 | 2021-12-18 | Tennessee Tech (310) | 63 | 72 | Wright State (124) | Final | L | -9 |
| 15 | 2021-12-21 | Tennessee Tech (310) | 67 | 76 | Cincinnati (54) | Final | L | -9 |
| 16 | 2021-12-21 | Tennessee Tech (313) | 75 | 86 | Cincinnati (64) | Final | L | -11 |
| 17 | 2021-12-30 | Tennessee Tech (310) | 0 | 0 | Tennessee State (165) | Postponed | - | - |
| 18 | 2022-01-01 | Tennessee Tech (310) | 0 | 0 | Murray State (116) | Postponed | - | - |
| 19 | 2022-01-13 | Tennessee Tech (310) | 77 | 92 | Belmont (68) | Final | L | -15 |
| 20 | 2022-01-15 | Tennessee Tech (310) | 76 | 70 | Tennessee-Martin (205) | Final | W | 6 |
| 21 | 2022-01-17 | Tennessee Tech (286) | 64 | 80 | Tennessee State (316) | Final | L | -16 |
| 22 | 2022-01-20 | SIU-Edwardsville (248) | 76 | 94 | Tennessee Tech (310) | Final | W | 18 |
| 23 | 2022-01-24 | Tennessee Tech (310) | 53 | 79 | Murray State (116) | Final | L | -26 |
| 24 | 2022-01-27 | Murray State (116) | 80 | 75 | Tennessee Tech (310) | Final | L | -5 |
| 25 | 2022-01-29 | Austin Peay (138) | 58 | 55 | Tennessee Tech (310) | Final | L | -3 |
| 26 | 2022-01-31 | Morehead State (122) | 70 | 56 | Tennessee Tech (285) | Final | L | -14 |
| 27 | 2022-02-03 | Tennessee Tech (310) | 68 | 75 | Morehead State (233) | Final | L | -7 |
| 28 | 2022-02-05 | Belmont (68) | 100 | 92 | Tennessee Tech (310) | Final/OT | L | -8 |
| 29 | 2022-02-07 | Eastern Illinois (314) | 58 | 84 | Tennessee Tech (310) | Final | W | 26 |
| 30 | 2022-02-10 | Tennessee Tech (310) | 73 | 62 | Eastern Illinois (314) | Final | W | 11 |
| 31 | 2022-02-12 | Tennessee Tech (310) | 60 | 61 | SIU-Edwardsville (248) | Final | L | -1 |
| 32 | 2022-02-17 | Southeast Missouri State (226) | 94 | 98 | Tennessee Tech (310) | Final | W | 4 |
| 33 | 2022-02-19 | Tennessee Tech (295) | 73 | 69 | Austin Peay (271) | Final | W | 4 |
| 34 | 2022-02-24 | Tennessee State (301) | 92 | 56 | Tennessee Tech (284) | Final | L | -36 |
| 35 | 2022-02-26 | Tennessee-Martin (319) | 75 | 88 | Tennessee Tech (284) | Final | W | 13 |
| 36 | 2022-03-02 | Tennessee Tech (289) | 78 | 51 | Austin Peay (266) | Final | W | 27 |
| 37 | 2022-03-03 | Tennessee Tech (289) | 56 | 73 | Morehead State (146) | Final | L | -17 |