Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Catawba | 58 | 91 | East Tennessee State (147) | Final | W | 33 |
| 2 | 2021-11-12 | East Tennessee State (140) | 67 | 69 | Appalachian State (159) | Final | L | -2 |
| 3 | 2021-11-14 | East Tennessee State (140) | 62 | 94 | Tennessee (18) | Final | L | -32 |
| 4 | 2021-11-18 | South Carolina Upstate (310) | 43 | 56 | East Tennessee State (325) | Final | W | 13 |
| 5 | 2021-11-22 | Murray State (116) | 58 | 66 | East Tennessee State (140) | Final | W | 8 |
| 6 | 2021-11-23 | Missouri State (140) | 76 | 77 | East Tennessee State (234) | Final | W | 1 |
| 7 | 2021-11-24 | East Tennessee State (140) | 57 | 51 | Kent State (107) | Final | W | 6 |
| 8 | 2021-11-27 | Lees McRae | 74 | 92 | East Tennessee State (234) | Final | W | 18 |
| 9 | 2021-12-01 | East Tennessee State (140) | 56 | 70 | UAB (115) | Final | L | -14 |
| 10 | 2021-12-04 | Lenoir Rhyne | 66 | 90 | East Tennessee State (140) | Final | W | 24 |
| 11 | 2021-12-11 | Morehead State (233) | 75 | 82 | East Tennessee State (140) | Final | W | 7 |
| 12 | 2021-12-14 | North Carolina A&T (294) | 69 | 67 | East Tennessee State (140) | Final | L | -2 |
| 13 | 2021-12-18 | East Tennessee State (140) | 64 | 79 | UNC-Asheville (244) | Final | L | -15 |
| 14 | 2021-12-22 | East Tennessee State (140) | 86 | 84 | Georgia (35) | Final | W | 2 |
| 15 | 2021-12-30 | East Tennessee State (140) | 52 | 82 | Chattanooga (291) | Final | L | -30 |
| 16 | 2022-01-01 | Western Carolina (223) | 0 | 0 | East Tennessee State (140) | Postponed | - | - |
| 17 | 2022-01-05 | Virginia Military (357) | 79 | 80 | East Tennessee State (140) | Final | W | 1 |
| 18 | 2022-01-08 | Wofford (221) | 68 | 57 | East Tennessee State (140) | Final | L | -11 |
| 19 | 2022-01-10 | Western Carolina (256) | 69 | 87 | East Tennessee State (146) | Final | W | 18 |
| 20 | 2022-01-12 | East Tennessee State (146) | 69 | 78 | Furman (106) | Final | L | -9 |
| 21 | 2022-01-15 | East Tennessee State (140) | 88 | 85 | Samford (203) | Final | W | 3 |
| 22 | 2022-01-19 | Mercer (174) | 64 | 72 | East Tennessee State (140) | Final | W | 8 |
| 23 | 2022-01-22 | The Citadel (332) | 75 | 73 | East Tennessee State (140) | Final | L | -2 |
| 24 | 2022-01-26 | UNC-Greensboro (176) | 80 | 76 | East Tennessee State (137) | Final | L | -4 |
| 25 | 2022-01-29 | East Tennessee State (140) | 79 | 83 | Virginia Military (357) | Final | L | -4 |
| 26 | 2022-02-02 | East Tennessee State (158) | 84 | 87 | Western Carolina (270) | Final | L | -3 |
| 27 | 2022-02-05 | East Tennessee State (140) | 60 | 62 | Wofford (221) | Final | L | -2 |
| 28 | 2022-02-07 | Furman (157) | 71 | 75 | East Tennessee State (140) | Final | W | 4 |
| 29 | 2022-02-12 | Samford (203) | 77 | 73 | East Tennessee State (140) | Final | L | -4 |
| 30 | 2022-02-16 | East Tennessee State (174) | 56 | 65 | Mercer (175) | Final | L | -9 |
| 31 | 2022-02-19 | East Tennessee State (174) | 77 | 67 | The Citadel (227) | Final | W | 10 |
| 32 | 2022-02-23 | Chattanooga (78) | 83 | 77 | East Tennessee State (175) | Final | L | -6 |
| 33 | 2022-02-27 | East Tennessee State (168) | 73 | 69 | UNC-Greensboro (155) | Final | W | 4 |
| 34 | 2022-03-04 | The Citadel (235) | 84 | 76 | East Tennessee State (168) | Final | L | -8 |