Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Longwood (283) | 73 | 106 | Iowa (7) | Final | L | -33 |
| 2 | 2021-11-12 | VU of Lynchburg | 46 | 80 | Longwood (269) | Final | W | 34 |
| 3 | 2021-11-14 | Mid-Atlantic | 47 | 93 | Longwood (226) | Final | W | 46 |
| 4 | 2021-11-19 | American (249) | 42 | 82 | Longwood (269) | Final | W | 40 |
| 5 | 2021-11-20 | UMBC (198) | 55 | 82 | Longwood (269) | Final | W | 27 |
| 6 | 2021-11-21 | Western Carolina (224) | 64 | 53 | Longwood (149) | Final | L | -11 |
| 7 | 2021-11-26 | Longwood (269) | 61 | 62 | Old Dominion (254) | Final | L | -1 |
| 8 | 2021-11-30 | Longwood (201) | 83 | 91 | Georgetown (236) | Final | L | -8 |
| 9 | 2021-12-04 | Delaware State (361) | 58 | 78 | Longwood (269) | Final | W | 20 |
| 10 | 2021-12-11 | Morgan State (337) | 55 | 94 | Longwood (269) | Final | W | 39 |
| 11 | 2021-12-14 | Carolina University | 56 | 98 | Longwood (269) | Final | W | 42 |
| 12 | 2021-12-19 | Longwood (269) | 0 | 0 | St. Francis (NY) | Cancelled | - | - |
| 13 | 2021-12-22 | Longwood (269) | 58 | 74 | Abilene Christian (245) | Final | L | -16 |
| 14 | 2021-12-30 | Longwood (269) | 0 | 0 | Maryland-Eastern Shore (353) | Cancelled | - | - |
| 15 | 2021-12-31 | Longwood (201) | 0 | 0 | Maryland-Eastern Shore (253) | Cancelled | - | - |
| 16 | 2022-01-05 | Pfeiffer | 69 | 109 | Longwood (269) | Final | W | 40 |
| 17 | 2022-01-08 | Longwood (269) | 0 | 0 | Charlotte (173) | Canceled | - | - |
| 18 | 2022-01-12 | Longwood (193) | 83 | 75 | Radford (292) | Final (OT) | W | 8 |
| 19 | 2022-01-15 | Gardner-Webb (363) | 60 | 66 | Longwood (269) | Final | W | 6 |
| 20 | 2022-01-19 | Campbell (191) | 64 | 72 | Longwood (269) | Final | W | 8 |
| 21 | 2022-01-22 | Longwood (269) | 71 | 70 | Presbyterian (264) | Final | W | 1 |
| 22 | 2022-01-24 | Longwood (269) | 73 | 48 | Hampton (260) | Final | W | 25 |
| 23 | 2022-01-24 | Longwood (162) | 73 | 49 | Hampton (332) | Final | W | 24 |
| 24 | 2022-01-26 | North Carolina A&T (276) | 71 | 79 | Longwood (162) | Final | W | 8 |
| 25 | 2022-01-29 | Winthrop (133) | 88 | 92 | Longwood (269) | Final | W | 4 |
| 26 | 2022-02-02 | Longwood (136) | 56 | 48 | UNC-Asheville (214) | Final | W | 8 |
| 27 | 2022-02-05 | Longwood (269) | 69 | 67 | Charleston Southern (262) | Final | W | 2 |
| 28 | 2022-02-10 | South Carolina Upstate (293) | 72 | 85 | Longwood (269) | Final | W | 13 |
| 29 | 2022-02-12 | Longwood (269) | 62 | 70 | North Carolina A&T (294) | Final | L | -8 |
| 30 | 2022-02-15 | High Point (249) | 66 | 70 | Longwood (154) | Final | W | 4 |
| 31 | 2022-02-17 | Longwood (269) | 78 | 71 | High Point (69) | Final | W | 7 |
| 32 | 2022-02-19 | Hampton (340) | 72 | 76 | Longwood (154) | Final | W | 4 |
| 33 | 2022-02-23 | Radford (287) | 66 | 71 | Longwood (141) | Final | W | 5 |
| 34 | 2022-02-26 | Longwood (141) | 60 | 55 | Campbell (222) | Final | W | 5 |
| 35 | 2022-03-04 | North Carolina A&T (299) | 65 | 79 | Longwood (132) | Final | W | 14 |
| 36 | 2022-03-05 | South Carolina Upstate (246) | 70 | 79 | Longwood (132) | Final | W | 9 |
| 37 | 2022-03-06 | Winthrop (133) | 58 | 79 | Longwood (118) | Final | W | 21 |
| 38 | 2022-03-17 | Longwood (119) | 56 | 88 | Tennessee (5) | Final | L | -32 |