Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Bethel (TN) | 58 | 87 | Tennessee-Martin (321) | Final | W | 29 |
| 2 | 2021-11-09 | Tennessee-Martin (321) | 62 | 90 | Tennessee (19) | Final | L | -28 |
| 3 | 2021-11-13 | Miami-Hamilton | 66 | 94 | Tennessee-Martin (321) | Final | W | 28 |
| 4 | 2021-11-19 | Tennessee-Martin (205) | 67 | 75 | Florida Atlantic (128) | Final | L | -8 |
| 5 | 2021-11-20 | Tennessee-Martin (205) | 67 | 80 | Troy (127) | Final | L | -13 |
| 6 | 2021-11-21 | Tennessee-Martin (270) | 77 | 72 | North Dakota (260) | Final | W | 5 |
| 7 | 2021-11-24 | Carver Bible | 43 | 103 | Tennessee-Martin (270) | Final | W | 60 |
| 8 | 2021-11-27 | Tennessee-Martin (270) | 66 | 81 | Western Kentucky (206) | Final | L | -15 |
| 9 | 2021-12-01 | Tennessee-Martin (205) | 61 | 73 | Middle Tennessee (164) | Final | L | -12 |
| 10 | 2021-12-04 | Tennessee-Martin (205) | 64 | 81 | Western Illinois (362) | Final | L | -17 |
| 11 | 2021-12-11 | Middle Tennessee (164) | 84 | 75 | Tennessee-Martin (205) | Final | L | -9 |
| 12 | 2021-12-14 | UNC-Asheville (244) | 68 | 79 | Tennessee-Martin (205) | Final | W | 11 |
| 13 | 2021-12-18 | Tennessee-Martin (205) | 0 | 0 | Evansville (302) | Cancelled | - | - |
| 14 | 2021-12-19 | Tennessee-Martin (205) | 54 | 80 | Drake (217) | Final | L | -26 |
| 15 | 2021-12-21 | Tennessee-Martin (205) | 0 | 0 | Kent State (107) | Cancelled | - | - |
| 16 | 2021-12-21 | Tennessee-Martin | 0 | 0 | Ohio State | Cancelled | - | - |
| 17 | 2021-12-30 | Tennessee-Martin (205) | 65 | 62 | Austin Peay (138) | Final | W | 3 |
| 18 | 2022-01-01 | SIU-Edwardsville (248) | 0 | 0 | Tennessee-Martin (205) | Postponed | - | - |
| 19 | 2022-01-06 | Tennessee-Martin (205) | 94 | 78 | Tennessee State (165) | Final | W | 16 |
| 20 | 2022-01-08 | Belmont (68) | 81 | 55 | Tennessee-Martin (205) | Final | L | -26 |
| 21 | 2022-01-12 | Tennessee-Martin (271) | 62 | 76 | Morehead State (139) | Final | L | -14 |
| 22 | 2022-01-15 | Tennessee Tech (310) | 76 | 70 | Tennessee-Martin (205) | Final | L | -6 |
| 23 | 2022-01-20 | Austin Peay (138) | 72 | 57 | Tennessee-Martin (205) | Final | L | -15 |
| 24 | 2022-01-22 | Tennessee-Martin (205) | 66 | 74 | Murray State (116) | Final | L | -8 |
| 25 | 2022-01-24 | SIU-Edwardsville (248) | 70 | 76 | Tennessee-Martin (205) | Final | W | 6 |
| 26 | 2022-01-27 | Eastern Illinois (314) | 58 | 53 | Tennessee-Martin (205) | Final | L | -5 |
| 27 | 2022-01-29 | Tennessee-Martin (205) | 58 | 87 | Belmont (68) | Final | L | -29 |
| 28 | 2022-02-03 | Southeast Missouri State (226) | 63 | 84 | Tennessee-Martin (205) | Final | W | 21 |
| 29 | 2022-02-05 | Tennessee State (165) | 69 | 61 | Tennessee-Martin (205) | Final | L | -8 |
| 30 | 2022-02-10 | Tennessee-Martin (205) | 63 | 71 | SIU-Edwardsville (248) | Final | L | -8 |
| 31 | 2022-02-12 | Tennessee-Martin (205) | 70 | 82 | Eastern Illinois (314) | Final | L | -12 |
| 32 | 2022-02-16 | Morehead State (116) | 68 | 60 | Tennessee-Martin (321) | Final | L | -8 |
| 33 | 2022-02-19 | Murray State (26) | 62 | 60 | Tennessee-Martin (321) | Final | L | -2 |
| 34 | 2022-02-24 | Tennessee-Martin (319) | 69 | 76 | Southeast Missouri State (298) | Final | L | -7 |
| 35 | 2022-02-26 | Tennessee-Martin (319) | 75 | 88 | Tennessee Tech (284) | Final | L | -13 |