Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Eastern New Mexico | 50 | 96 | Arizona (46) | Final | W | 46 |
| 2 | 2021-11-09 | Northern Arizona (316) | 52 | 81 | Arizona (46) | Final | W | 29 |
| 3 | 2021-11-12 | UTRGV (161) | 50 | 104 | Arizona (2) | Final | W | 54 |
| 4 | 2021-11-16 | North Dakota State (100) | 45 | 97 | Arizona (25) | Final | W | 52 |
| 5 | 2021-11-19 | Wichita State (76) | 78 | 82 | Arizona (2) | Final/OT | W | 4 |
| 6 | 2021-11-21 | Michigan (67) | 62 | 80 | Arizona (1) | Final | W | 18 |
| 7 | 2021-11-27 | Sacramento State (221) | 59 | 105 | Arizona (1) | Final | W | 46 |
| 8 | 2021-12-05 | Arizona (3) | 90 | 65 | Oregon State (257) | Final | W | 25 |
| 9 | 2021-12-08 | Wyoming (27) | 65 | 94 | Arizona (4) | Final | W | 29 |
| 10 | 2021-12-11 | Arizona (2) | 83 | 79 | Illinois (9) | Final | W | 4 |
| 11 | 2021-12-15 | Northern Colorado (196) | 76 | 101 | Arizona (2) | Final | W | 25 |
| 12 | 2021-12-18 | California Baptist (97) | 60 | 84 | Arizona (2) | Final | W | 24 |
| 13 | 2021-12-22 | Arizona (2) | 73 | 77 | Tennessee (18) | Final | L | -4 |
| 14 | 2021-12-30 | Arizona (2) | 0 | 0 | UCLA (30) | Postponed | - | - |
| 15 | 2022-01-02 | Arizona (2) | 0 | 0 | USC (71) | Postponed | - | - |
| 16 | 2022-01-03 | Washington (72) | 79 | 95 | Arizona (2) | Final | W | 16 |
| 17 | 2022-01-08 | Arizona (2) | 0 | 0 | Arizona State (61) | Postponed | - | - |
| 18 | 2022-01-13 | Colorado (73) | 55 | 76 | Arizona (2) | Final | W | 21 |
| 19 | 2022-01-15 | Utah (130) | 64 | 82 | Arizona (2) | Final | W | 18 |
| 20 | 2022-01-20 | Arizona (2) | 85 | 57 | Stanford (60) | Final | W | 28 |
| 21 | 2022-01-23 | Arizona (2) | 96 | 71 | California (129) | Final | W | 25 |
| 22 | 2022-01-25 | Arizona (2) | 59 | 75 | UCLA (11) | Final | L | -16 |
| 23 | 2022-01-29 | Arizona State (61) | 56 | 67 | Arizona (2) | Final | W | 11 |
| 24 | 2022-02-03 | UCLA (30) | 66 | 76 | Arizona (2) | Final | W | 10 |
| 25 | 2022-02-05 | USC (71) | 63 | 72 | Arizona (2) | Final | W | 9 |
| 26 | 2022-02-07 | Arizona (2) | 91 | 79 | Arizona State (61) | Final | W | 12 |
| 27 | 2022-02-10 | Arizona (2) | 72 | 60 | Washington State (179) | Final | W | 12 |
| 28 | 2022-02-12 | Arizona (2) | 92 | 68 | Washington (72) | Final | W | 24 |
| 29 | 2022-02-17 | Oregon State (144) | 69 | 83 | Arizona (2) | Final | W | 14 |
| 30 | 2022-02-19 | Oregon (58) | 81 | 84 | Arizona (1) | Final | W | 3 |
| 31 | 2022-02-24 | Arizona (2) | 97 | 77 | Utah (130) | Final | W | 20 |
| 32 | 2022-02-26 | Arizona (2) | 63 | 79 | Colorado (66) | Final | L | -16 |
| 33 | 2022-03-01 | Arizona (2) | 91 | 71 | USC (18) | Final | W | 20 |
| 34 | 2022-03-03 | Stanford (88) | 69 | 81 | Arizona (2) | Final | W | 12 |
| 35 | 2022-03-05 | California (129) | 61 | 89 | Arizona (2) | Final | W | 28 |
| 36 | 2022-03-10 | Stanford (97) | 80 | 84 | Arizona (1) | Final | W | 4 |
| 37 | 2022-03-11 | Colorado (58) | 72 | 82 | Arizona (1) | Final | W | 10 |
| 38 | 2022-03-12 | UCLA (13) | 76 | 84 | Arizona (1) | Final | W | 8 |
| 39 | 2022-03-18 | Wright State (195) | 70 | 87 | Arizona (1) | Final | W | 17 |
| 40 | 2022-03-20 | TCU (35) | 80 | 85 | Arizona (1) | Final (OT) | W | 5 |
| 41 | 2022-03-24 | Houston (9) | 72 | 60 | Arizona (1) | Final | L | -12 |