Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | Drexel (150) | 73 | 89 | Penn | Final | L | -16 |
| 2 | 2021-11-09 | Neumann | 74 | 103 | Drexel (150) | Final | W | 29 |
| 3 | 2021-11-12 | Fairleigh Dickinson (343) | 0 | 0 | Drexel (215) | Postponed | - | - |
| 4 | 2021-11-14 | Drexel (215) | 60 | 75 | Syracuse (84) | Final | L | -15 |
| 5 | 2021-11-17 | Drexel (215) | 78 | 75 | Saint Joseph's (99) | Final | W | 3 |
| 6 | 2021-11-22 | Tulane (167) | 90 | 87 | Drexel (215) | Final/OT | L | -3 |
| 7 | 2021-11-23 | Drexel (189) | 67 | 55 | Charlotte (48) | Final | W | 12 |
| 8 | 2021-11-24 | Drexel (215) | 64 | 72 | Jacksonville State (227) | Final | L | -8 |
| 9 | 2021-12-02 | Fairleigh Dickinson (341) | 65 | 86 | Drexel (227) | Final | W | 21 |
| 10 | 2021-12-04 | Drexel (215) | 79 | 81 | Princeton (271) | Final/OT | L | -2 |
| 11 | 2021-12-11 | Drexel (215) | 56 | 73 | Abilene Christian (245) | Final | L | -17 |
| 12 | 2021-12-14 | Coppin State (360) | 69 | 76 | Drexel (215) | Final | W | 7 |
| 13 | 2021-12-18 | Drexel (215) | 0 | 0 | Temple (169) | Cancelled | - | - |
| 14 | 2021-12-21 | Drexel (215) | 0 | 0 | La Salle (237) | Cancelled | - | - |
| 15 | 2021-12-29 | Drexel (215) | 0 | 0 | Charleston (123) | Postponed | - | - |
| 16 | 2021-12-31 | Drexel (215) | 0 | 0 | UNC-Wilmington (90) | Postponed | - | - |
| 17 | 2022-01-03 | Towson (152) | 61 | 65 | Drexel (215) | Final | W | 4 |
| 18 | 2022-01-11 | Delaware (287) | 81 | 77 | Drexel (215) | Final | L | -4 |
| 19 | 2022-01-15 | Drexel (215) | 76 | 68 | Northeastern (300) | Final | W | 8 |
| 20 | 2022-01-17 | Drexel (166) | 68 | 71 | Hofstra (119) | Final | L | -3 |
| 21 | 2022-01-20 | Elon (232) | 49 | 77 | Drexel (215) | Final | W | 28 |
| 22 | 2022-01-22 | William & Mary (141) | 83 | 75 | Drexel (215) | Final | L | -8 |
| 23 | 2022-01-27 | Drexel (215) | 88 | 82 | James Madison (202) | Final | W | 6 |
| 24 | 2022-01-29 | Drexel (215) | 62 | 66 | Towson (152) | Final | L | -4 |
| 25 | 2022-02-03 | Drexel (215) | 76 | 68 | Delaware (287) | Final | W | 8 |
| 26 | 2022-02-07 | James Madison (202) | 66 | 72 | Drexel (215) | Final | W | 6 |
| 27 | 2022-02-10 | Hofstra (98) | 83 | 73 | Drexel (215) | Final | L | -10 |
| 28 | 2022-02-12 | Northeastern (300) | 51 | 67 | Drexel (215) | Final | W | 16 |
| 29 | 2022-02-14 | Drexel (215) | 75 | 79 | Charleston (123) | Final | L | -4 |
| 30 | 2022-02-17 | Drexel (215) | 72 | 57 | William & Mary (141) | Final | W | 15 |
| 31 | 2022-02-19 | Drexel (170) | 71 | 60 | Elon (262) | Final | W | 11 |
| 32 | 2022-02-24 | UNC-Wilmington (147) | 69 | 63 | Drexel (165) | Final | L | -6 |
| 33 | 2022-02-26 | Charleston (163) | 79 | 80 | Drexel (165) | Final | W | 1 |
| 34 | 2022-03-06 | Delaware (134) | 66 | 56 | Drexel (174) | Final | L | -10 |