Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Northeastern (153) | 58 | 65 | Colgate (12) | Final | W | 7 |
| 2 | 2021-11-13 | Colgate (12) | 74 | 77 | North Carolina State (80) | Final | L | -3 |
| 3 | 2021-11-16 | Colgate (175) | 68 | 78 | Cornell (73) | Final | L | -10 |
| 4 | 2021-11-18 | SUNY Polytechnic | 50 | 97 | Colgate (175) | Final | W | 47 |
| 5 | 2021-11-20 | Colgate (239) | 100 | 85 | Syracuse (84) | Final | W | 15 |
| 6 | 2021-11-24 | Colgate (239) | 84 | 89 | Harvard (181) | Final/OT | L | -5 |
| 7 | 2021-11-29 | Niagara (207) | 70 | 59 | Colgate (166) | Final | L | -11 |
| 8 | 2021-12-03 | Colgate (239) | 69 | 74 | Northeastern (300) | Final | L | -5 |
| 9 | 2021-12-06 | Columbia (337) | 61 | 89 | Colgate (213) | Final | W | 28 |
| 10 | 2021-12-09 | Colgate (213) | 68 | 71 | Pittsburgh (235) | Final | L | -3 |
| 11 | 2021-12-12 | Colgate (239) | 64 | 82 | St. John's (12) | Final | L | -18 |
| 12 | 2021-12-19 | Colgate (239) | 66 | 77 | Monmouth (176) | Final | L | -11 |
| 13 | 2021-12-22 | Colgate (239) | 68 | 78 | Vermont (225) | Final | L | -10 |
| 14 | 2022-01-01 | Colgate (239) | 0 | 0 | Lafayette (323) | Postponed | - | - |
| 15 | 2022-01-04 | Colgate (239) | 81 | 85 | Lehigh (276) | Final | L | -4 |
| 16 | 2022-01-07 | American (249) | 0 | 0 | Colgate (239) | Postponed | - | - |
| 17 | 2022-01-10 | Army (221) | 57 | 76 | Colgate (280) | Final | W | 19 |
| 18 | 2022-01-13 | Colgate (239) | 69 | 50 | Navy (149) | Final | W | 19 |
| 19 | 2022-01-19 | Colgate (239) | 75 | 56 | Bucknell (336) | Final | W | 19 |
| 20 | 2022-01-22 | Lafayette (323) | 0 | 0 | Colgate (239) | Postponed | - | - |
| 21 | 2022-01-24 | Loyola-Maryland (325) | 52 | 65 | Colgate (239) | Final | W | 13 |
| 22 | 2022-01-28 | Colgate (233) | 72 | 76 | Boston University (198) | Final | L | -4 |
| 23 | 2022-01-31 | Colgate (229) | 72 | 61 | Lafayette (315) | Final | W | 11 |
| 24 | 2022-02-02 | Bucknell (335) | 69 | 83 | Colgate (229) | Final | W | 14 |
| 25 | 2022-02-05 | Colgate (239) | 86 | 68 | American (249) | Final | W | 18 |
| 26 | 2022-02-07 | Holy Cross (334) | 60 | 87 | Colgate (239) | Final | W | 27 |
| 27 | 2022-02-09 | Lehigh (276) | 62 | 78 | Colgate (239) | Final | W | 16 |
| 28 | 2022-02-12 | Colgate (239) | 64 | 56 | Loyola-Maryland (325) | Final | W | 8 |
| 29 | 2022-02-14 | Lafayette (323) | 61 | 69 | Colgate (239) | Final | W | 8 |
| 30 | 2022-02-16 | Colgate (199) | 100 | 90 | Army (268) | Final | W | 10 |
| 31 | 2022-02-19 | Boston University (198) | 53 | 72 | Colgate (199) | Final | W | 19 |
| 32 | 2022-02-21 | American (327) | 49 | 63 | Colgate (182) | Final | W | 14 |
| 33 | 2022-02-23 | Colgate (182) | 78 | 71 | Holy Cross (326) | Final | W | 7 |
| 34 | 2022-02-26 | Navy (173) | 69 | 74 | Colgate (182) | Final | W | 5 |
| 35 | 2022-03-03 | Bucknell (331) | 68 | 96 | Colgate (172) | Final | W | 28 |
| 36 | 2022-03-06 | Lehigh (299) | 61 | 81 | Colgate (168) | Final | W | 20 |
| 37 | 2022-03-09 | Navy (173) | 58 | 74 | Colgate (168) | Final | W | 16 |
| 38 | 2022-03-18 | Colgate (157) | 60 | 67 | Wisconsin (15) | Final | L | -7 |