Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Lehigh (278) | 70 | 73 | Rutgers (35) | Final (OT) | L | -3 |
| 2 | 2021-11-13 | NJIT (274) | 73 | 56 | Lehigh (278) | Final | L | -17 |
| 3 | 2021-11-16 | Lehigh (321) | 75 | 85 | Monmouth (142) | Final | L | -10 |
| 4 | 2021-11-19 | Lehigh (276) | 45 | 55 | Merrimack (134) | Final | L | -10 |
| 5 | 2021-11-23 | Columbia (255) | 72 | 79 | Lehigh (350) | Final | W | 7 |
| 6 | 2021-11-26 | Lehigh (276) | 43 | 61 | Virginia (14) | Final | L | -18 |
| 7 | 2021-11-28 | St. Francis (PA) (274) | 79 | 68 | Lehigh (333) | Final | L | -11 |
| 8 | 2021-12-01 | Lehigh (276) | 72 | 82 | Yale (81) | Final | L | -10 |
| 9 | 2021-12-04 | Maryland-Eastern Shore (353) | 81 | 75 | Lehigh (276) | Final | L | -6 |
| 10 | 2021-12-18 | Lehigh (276) | 0 | 0 | Syracuse (84) | Cancelled | - | - |
| 11 | 2021-12-21 | Albany (330) | 68 | 52 | Lehigh (276) | Final | L | -16 |
| 12 | 2021-12-28 | Lehigh (276) | 55 | 76 | Maryland (114) | Final | L | -21 |
| 13 | 2021-12-29 | Eastern | 63 | 70 | Lehigh (276) | Final | W | 7 |
| 14 | 2022-01-01 | Lehigh (276) | 63 | 61 | American (249) | Final | W | 2 |
| 15 | 2022-01-04 | Colgate (239) | 81 | 85 | Lehigh (276) | Final | W | 4 |
| 16 | 2022-01-07 | Lehigh (276) | 55 | 77 | Army (339) | Final | L | -22 |
| 17 | 2022-01-10 | Holy Cross (349) | 69 | 77 | Lehigh (333) | Final | W | 8 |
| 18 | 2022-01-13 | Lehigh (276) | 97 | 64 | Bucknell (336) | Final | W | 33 |
| 19 | 2022-01-16 | Loyola-Maryland (209) | 69 | 57 | Lehigh (319) | Final | L | -12 |
| 20 | 2022-01-19 | Lehigh (276) | 69 | 61 | Navy (149) | Final | W | 8 |
| 21 | 2022-01-22 | Lehigh (276) | 74 | 80 | Boston University (267) | Final | L | -6 |
| 22 | 2022-01-26 | Army (227) | 71 | 84 | Lehigh (309) | Final | W | 13 |
| 23 | 2022-01-28 | Lehigh (309) | 65 | 67 | Holy Cross (351) | Final | L | -2 |
| 24 | 2022-02-02 | Navy (154) | 62 | 63 | Lehigh (306) | Final | W | 1 |
| 25 | 2022-02-05 | Boston University (267) | 80 | 74 | Lehigh (276) | Final | L | -6 |
| 26 | 2022-02-09 | Lehigh (276) | 62 | 78 | Colgate (239) | Final | L | -16 |
| 27 | 2022-02-12 | Lafayette (323) | 73 | 69 | Lehigh (276) | Final | L | -4 |
| 28 | 2022-02-14 | Bucknell (336) | 77 | 86 | Lehigh (276) | Final | W | 9 |
| 29 | 2022-02-20 | Lehigh (309) | 42 | 69 | Loyola-Maryland (267) | Final | L | -27 |
| 30 | 2022-02-23 | American (327) | 61 | 78 | Lehigh (309) | Final | W | 17 |
| 31 | 2022-02-26 | Lehigh (309) | 78 | 58 | Lafayette (307) | Final | W | 20 |
| 32 | 2022-03-03 | Army (271) | 77 | 91 | Lehigh (300) | Final | W | 14 |
| 33 | 2022-03-06 | Lehigh (299) | 61 | 81 | Colgate (168) | Final | L | -20 |