Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-25 | St. Rose | 0 | 0 | Siena (142) | Cancelled | - | - |
| 2 | 2021-11-09 | Siena (142) | 47 | 75 | St. Bonaventure (29) | Final | L | -28 |
| 3 | 2021-11-13 | Delaware (240) | 83 | 63 | Siena (142) | Final | L | -20 |
| 4 | 2021-11-16 | Yale (132) | 82 | 54 | Siena (347) | Final | L | -28 |
| 5 | 2021-11-19 | Siena (160) | 65 | 83 | Georgetown (83) | Final | L | -18 |
| 6 | 2021-11-22 | Harvard (181) | 69 | 72 | Siena (160) | Final | W | 3 |
| 7 | 2021-11-28 | Siena (330) | 56 | 65 | Bucknell (311) | Final (OT) | L | -9 |
| 8 | 2021-11-30 | Siena (330) | 83 | 67 | Army (164) | Final | W | 16 |
| 9 | 2021-12-03 | Manhattan (307) | 77 | 72 | Siena (160) | Final/OT | L | -5 |
| 10 | 2021-12-05 | Siena (330) | 60 | 58 | Saint Peter's (242) | Final | W | 2 |
| 11 | 2021-12-11 | Siena (160) | 72 | 59 | Holy Cross (334) | Final | W | 13 |
| 12 | 2021-12-28 | Siena (160) | 0 | 0 | American (249) | Cancelled | - | - |
| 13 | 2021-12-31 | Siena (160) | 0 | 0 | Iona (220) | Postponed | - | - |
| 14 | 2022-01-02 | Canisius (328) | 0 | 0 | Siena (160) | Postponed | - | - |
| 15 | 2022-01-07 | Siena (160) | 0 | 0 | Monmouth (176) | Postponed | - | - |
| 16 | 2022-01-09 | Fairfield (203) | 62 | 69 | Siena (263) | Final | W | 7 |
| 17 | 2022-01-14 | Siena (263) | 67 | 60 | Marist (198) | Final | W | 7 |
| 18 | 2022-01-21 | Siena (233) | 68 | 75 | Manhattan (150) | Final | L | -7 |
| 19 | 2022-01-28 | Niagara (220) | 56 | 60 | Siena (243) | Final | W | 4 |
| 20 | 2022-01-30 | Quinnipiac (220) | 76 | 85 | Siena (218) | Final | W | 9 |
| 21 | 2022-02-01 | Canisius (269) | 65 | 73 | Siena (218) | Final | W | 8 |
| 22 | 2022-02-04 | Rider (292) | 74 | 60 | Siena (218) | Final | L | -14 |
| 23 | 2022-02-06 | Siena (160) | 62 | 56 | Fairfield (204) | Final | W | 6 |
| 24 | 2022-02-11 | Iona (220) | 64 | 70 | Siena (160) | Final | W | 6 |
| 25 | 2022-02-13 | Siena (195) | 76 | 75 | Rider (270) | Final (OT) | W | 1 |
| 26 | 2022-02-18 | Marist (223) | 62 | 53 | Siena (195) | Final | L | -9 |
| 27 | 2022-02-20 | Saint Peter's (181) | 70 | 84 | Siena (197) | Final | W | 14 |
| 28 | 2022-02-22 | Siena (197) | 59 | 71 | Monmouth (118) | Final | L | -12 |
| 29 | 2022-02-24 | Siena (197) | 78 | 71 | Quinnipiac (234) | Final | W | 7 |
| 30 | 2022-02-27 | Monmouth (128) | 59 | 70 | Siena (186) | Final | W | 11 |
| 31 | 2022-03-03 | Siena (186) | 52 | 74 | Niagara (225) | Final | L | -22 |
| 32 | 2022-03-05 | Siena (186) | 64 | 67 | Canisius (269) | Final | L | -3 |
| 33 | 2022-03-10 | Quinnipiac (249) | 77 | 71 | Siena (204) | Final | L | -6 |