Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Coppin State (273) | 45 | 103 | Loyola-Chicago (27) | Final | L | -58 |
| 2 | 2021-11-10 | Coppin State (273) | 72 | 97 | DePaul (177) | Final | L | -25 |
| 3 | 2021-11-12 | Coppin State (360) | 69 | 81 | Rider (356) | Final | L | -12 |
| 4 | 2021-11-13 | Coppin State (273) | 54 | 89 | Connecticut (32) | Final | L | -35 |
| 5 | 2021-11-15 | Coppin State (356) | 48 | 55 | UNC-Greensboro (92) | Final | L | -7 |
| 6 | 2021-11-17 | Loyola-Maryland (325) | 49 | 71 | Coppin State (360) | Final | W | 22 |
| 7 | 2021-11-19 | Coppin State (360) | 52 | 68 | Virginia (14) | Final | L | -16 |
| 8 | 2021-11-22 | Coppin State (360) | 62 | 65 | Cleveland State (308) | Final | L | -3 |
| 9 | 2021-11-24 | Coppin State (360) | 75 | 76 | Canisius (328) | Final | L | -1 |
| 10 | 2021-11-27 | Coppin State (341) | 68 | 70 | East Carolina (132) | Final | L | -2 |
| 11 | 2021-12-01 | Coppin State (360) | 81 | 93 | St. Bonaventure (146) | Final | L | -12 |
| 12 | 2021-12-03 | Coppin State (360) | 77 | 92 | Cornell (187) | Final | L | -15 |
| 13 | 2021-12-08 | Coppin State (331) | 62 | 75 | George Washington (299) | Final | L | -13 |
| 14 | 2021-12-11 | Towson (152) | 89 | 75 | Coppin State (360) | Final | L | -14 |
| 15 | 2021-12-14 | Coppin State (360) | 69 | 76 | Drexel (215) | Final | L | -7 |
| 16 | 2021-12-23 | Coppin State | 0 | 0 | George Mason | Cancelled | - | - |
| 17 | 2022-01-08 | Coppin State (360) | 74 | 65 | South Carolina State (355) | Final | W | 9 |
| 18 | 2022-01-15 | Coppin State (360) | 79 | 76 | Morgan State (337) | Final | W | 3 |
| 19 | 2022-01-22 | Coppin State (360) | 77 | 84 | Norfolk State (322) | Final | L | -7 |
| 20 | 2022-01-24 | Howard (211) | 81 | 83 | Coppin State (360) | Final | W | 2 |
| 21 | 2022-01-29 | Maryland-Eastern Shore (353) | 64 | 61 | Coppin State (360) | Final | L | -3 |
| 22 | 2022-02-02 | Coppin State (307) | 59 | 57 | Delaware State (357) | Final | W | 2 |
| 23 | 2022-02-05 | Coppin State (360) | 68 | 69 | North Carolina Central (341) | Final | L | -1 |
| 24 | 2022-02-12 | South Carolina State (355) | 66 | 58 | Coppin State (360) | Final | L | -8 |
| 25 | 2022-02-14 | North Carolina Central (341) | 77 | 74 | Coppin State (360) | Final | L | -3 |
| 26 | 2022-02-19 | Norfolk State (158) | 89 | 59 | Coppin State (313) | Final | L | -30 |
| 27 | 2022-02-21 | Coppin State (322) | 86 | 82 | Howard (240) | Final | W | 4 |
| 28 | 2022-02-26 | Coppin State (322) | 50 | 70 | Maryland-Eastern Shore (302) | Final | L | -20 |
| 29 | 2022-02-28 | Delaware State (358) | 67 | 80 | Coppin State (317) | Final | W | 13 |
| 30 | 2022-03-03 | Morgan State (313) | 63 | 59 | Coppin State (317) | Final | L | -4 |
| 31 | 2022-03-09 | Coppin State (319) | 59 | 57 | Howard (243) | Final | W | 2 |
| 32 | 2022-03-11 | Coppin State (319) | 79 | 73 | North Carolina Central (270) | Final | W | 6 |
| 33 | 2022-03-12 | Coppin State (319) | 57 | 72 | Norfolk State (153) | Final | L | -15 |