Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Nicholls State (159) | 62 | 58 | Northern Iowa (204) | Final | L | -4 |
| 2 | 2021-11-11 | Vermont (137) | 71 | 57 | Northern Iowa (204) | Final | L | -14 |
| 3 | 2021-11-14 | Dubuque | 58 | 95 | Northern Iowa (89) | Final | W | 37 |
| 4 | 2021-11-17 | Northern Iowa (89) | 80 | 93 | Arkansas (16) | Final | L | -13 |
| 5 | 2021-11-27 | Northern Iowa (299) | 90 | 80 | St. Bonaventure (2) | Final | W | 10 |
| 6 | 2021-12-01 | Northern Iowa (89) | 69 | 71 | Bradley (113) | Final | L | -2 |
| 7 | 2021-12-05 | Richmond (155) | 60 | 52 | Northern Iowa (192) | Final | L | -8 |
| 8 | 2021-12-14 | Jackson State (329) | 56 | 66 | Northern Iowa (89) | Final | W | 10 |
| 9 | 2021-12-18 | Northern Iowa (89) | 75 | 60 | Marshall (155) | Final | W | 15 |
| 10 | 2021-12-22 | Liberty (93) | 76 | 74 | Northern Iowa (89) | Final | L | -2 |
| 11 | 2021-12-23 | Northern Iowa (89) | 69 | 71 | Wyoming (103) | Final | L | -2 |
| 12 | 2021-12-25 | Northern Iowa (89) | 0 | 0 | Hawaii (109) | Cancelled | - | - |
| 13 | 2021-12-29 | Wartburg | 0 | 0 | Northern Iowa (89) | Cancelled | - | - |
| 14 | 2022-01-02 | Evansville (302) | 61 | 83 | Northern Iowa (89) | Final | W | 22 |
| 15 | 2022-01-05 | Valparaiso (156) | 65 | 92 | Northern Iowa (89) | Final | W | 27 |
| 16 | 2022-01-08 | Northern Iowa (89) | 85 | 84 | Missouri State (224) | Final | W | 1 |
| 17 | 2022-01-11 | Indiana State (243) | 74 | 80 | Northern Iowa (89) | Final/OT | W | 6 |
| 18 | 2022-01-15 | Northern Iowa (89) | 69 | 68 | Southern Illinois (150) | Final | W | 1 |
| 19 | 2022-01-19 | Northern Iowa (89) | 80 | 83 | Valparaiso (156) | Final/OT | L | -3 |
| 20 | 2022-01-22 | Drake (217) | 82 | 74 | Northern Iowa (89) | Final/OT | L | -8 |
| 21 | 2022-01-26 | Northern Iowa (147) | 64 | 59 | Evansville (310) | Final | W | 5 |
| 22 | 2022-01-29 | Illinois State (94) | 64 | 79 | Northern Iowa (89) | Final | W | 15 |
| 23 | 2022-02-02 | Bradley (144) | 65 | 78 | Northern Iowa (138) | Final | W | 13 |
| 24 | 2022-02-05 | Northern Iowa (89) | 74 | 69 | Drake (217) | Final/OT | W | 5 |
| 25 | 2022-02-09 | Southern Illinois (150) | 44 | 53 | Northern Iowa (89) | Final | W | 9 |
| 26 | 2022-02-13 | Northern Iowa (119) | 58 | 85 | Loyola-Chicago (40) | Final | L | -27 |
| 27 | 2022-02-15 | Northern Iowa (119) | 72 | 70 | Illinois State (248) | Final | W | 2 |
| 28 | 2022-02-20 | Missouri State (98) | 75 | 95 | Northern Iowa (113) | Final | W | 20 |
| 29 | 2022-02-23 | Northern Iowa (113) | 88 | 82 | Indiana State (243) | Final | W | 6 |
| 30 | 2022-02-26 | Loyola-Chicago (50) | 96 | 102 | Northern Iowa (113) | Final | W | 6 |
| 31 | 2022-03-04 | Illinois State (253) | 65 | 78 | Northern Iowa (105) | Final | W | 13 |
| 32 | 2022-03-05 | Loyola-Chicago (53) | 66 | 43 | Northern Iowa (105) | Final | L | -23 |
| 33 | 2022-03-16 | Northern Iowa (89) | 80 | 68 | Saint Louis (31) | Final | W | 12 |
| 34 | 2022-03-19 | Northern Iowa (105) | 71 | 90 | BYU (64) | Final | L | -19 |