Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Medaille College | 54 | 105 | Buffalo (99) | Final | W | 51 |
| 2 | 2021-11-10 | Buffalo (99) | 76 | 88 | Michigan (4) | Final | L | -12 |
| 3 | 2021-11-15 | Buffalo (249) | 69 | 66 | North Texas (177) | Final | W | 3 |
| 4 | 2021-11-20 | Rider (356) | 65 | 87 | Buffalo (219) | Final | W | 22 |
| 5 | 2021-11-23 | Stephen F. Austin (191) | 79 | 78 | Buffalo (126) | Final | L | -1 |
| 6 | 2021-11-24 | Buffalo (219) | 106 | 90 | Illinois State (94) | Final | W | 16 |
| 7 | 2021-11-29 | Point Park | 49 | 94 | Buffalo (131) | Final | W | 45 |
| 8 | 2021-12-04 | Buffalo (219) | 65 | 68 | St. Bonaventure (146) | Final | L | -3 |
| 9 | 2021-12-08 | Buffalo (152) | 77 | 67 | Western Kentucky (132) | Final | W | 10 |
| 10 | 2021-12-11 | St. John Fisher | 58 | 100 | Buffalo (219) | Final | W | 42 |
| 11 | 2021-12-18 | Buffalo (219) | 64 | 65 | Canisius (328) | Final | L | -1 |
| 12 | 2021-12-21 | UC-Irvine (119) | 0 | 0 | Buffalo (219) | Cancelled | - | - |
| 13 | 2021-12-29 | Miami (OH) (40) | 91 | 81 | Buffalo (219) | Final | L | -10 |
| 14 | 2022-01-01 | Buffalo (219) | 0 | 0 | Eastern Michigan (277) | Postponed | - | - |
| 15 | 2022-01-01 | Buffalo (219) | 76 | 88 | Akron (59) | Final | L | -12 |
| 16 | 2022-01-04 | Buffalo (219) | 0 | 0 | Northern Illinois (326) | Postponed | - | - |
| 17 | 2022-01-05 | Bowling Green (168) | 88 | 99 | Buffalo (219) | Final | W | 11 |
| 18 | 2022-01-11 | Buffalo (219) | 78 | 64 | Western Michigan (304) | Final | W | 14 |
| 19 | 2022-01-14 | Buffalo (156) | 74 | 68 | Ball State (246) | Final | W | 6 |
| 20 | 2022-01-18 | Central Michigan (311) | 0 | 0 | Buffalo (219) | Canceled | - | - |
| 21 | 2022-01-21 | Kent State (167) | 51 | 64 | Buffalo (152) | Final | W | 13 |
| 22 | 2022-01-25 | Buffalo (140) | 75 | 86 | Toledo (65) | Final | L | -11 |
| 23 | 2022-01-28 | Ohio (60) | 74 | 53 | Buffalo (140) | Final | L | -21 |
| 24 | 2022-02-05 | Buffalo (219) | 74 | 54 | Central Michigan (311) | Final | W | 20 |
| 25 | 2022-02-08 | Eastern Michigan (272) | 64 | 102 | Buffalo (152) | Final | W | 38 |
| 26 | 2022-02-12 | Ball State (298) | 74 | 80 | Buffalo (219) | Final | W | 6 |
| 27 | 2022-02-15 | Buffalo (132) | 112 | 85 | Bowling Green (241) | Final | W | 27 |
| 28 | 2022-02-17 | Buffalo (219) | 83 | 69 | Eastern Michigan (277) | Final | W | 14 |
| 29 | 2022-02-19 | Western Michigan (346) | 73 | 87 | Buffalo (132) | Final | W | 14 |
| 30 | 2022-02-22 | Buffalo (125) | 86 | 84 | Miami (OH) (251) | Final | W | 2 |
| 31 | 2022-02-24 | Buffalo (125) | 79 | 68 | Northern Illinois (291) | Final | W | 11 |
| 32 | 2022-02-26 | Northern Illinois (291) | 60 | 70 | Buffalo (125) | Final | W | 10 |
| 33 | 2022-03-01 | Toledo (75) | 92 | 76 | Buffalo (116) | Final | L | -16 |
| 34 | 2022-03-04 | Buffalo (116) | 65 | 70 | Kent State (118) | Final | L | -5 |
| 35 | 2022-03-10 | Buffalo (122) | 68 | 70 | Akron (132) | Final | L | -2 |