Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Northeastern (153) | 58 | 65 | Colgate (12) | Final | L | -7 |
| 2 | 2021-11-12 | Northeastern (300) | 64 | 83 | Georgia State (299) | Final | L | -19 |
| 3 | 2021-11-16 | Boston University (237) | 48 | 49 | Northeastern (322) | Final | W | 1 |
| 4 | 2021-11-19 | Northeastern (300) | 71 | 55 | Duquesne (121) | Final | W | 16 |
| 5 | 2021-11-21 | Northeastern (136) | 59 | 47 | Southern Illinois (173) | Final | W | 12 |
| 6 | 2021-11-22 | Colorado State (85) | 71 | 61 | Northeastern (300) | Final | L | -10 |
| 7 | 2021-11-27 | Northeastern (136) | 57 | 77 | Harvard (179) | Final | L | -20 |
| 8 | 2021-11-30 | Detroit (314) | 56 | 66 | Northeastern (196) | Final | W | 10 |
| 9 | 2021-12-03 | Colgate (239) | 69 | 74 | Northeastern (300) | Final | W | 5 |
| 10 | 2021-12-07 | Massachusetts (182) | 76 | 82 | Northeastern (300) | Final | W | 6 |
| 11 | 2021-12-12 | Davidson (111) | 79 | 69 | Northeastern (300) | Final | L | -10 |
| 12 | 2021-12-19 | Vermont (225) | 0 | 0 | Northeastern (300) | Cancelled | - | - |
| 13 | 2021-12-22 | St. Bonaventure (146) | 0 | 0 | Northeastern (300) | Cancelled | - | - |
| 14 | 2021-12-29 | Northeastern (300) | 62 | 79 | Elon (232) | Final | L | -17 |
| 15 | 2021-12-31 | Northeastern (300) | 70 | 71 | William & Mary (141) | Final | L | -1 |
| 16 | 2022-01-03 | Charleston (123) | 0 | 0 | Northeastern (300) | Postponed | - | - |
| 17 | 2022-01-05 | UNC-Wilmington (90) | 0 | 0 | Northeastern (300) | Postponed | - | - |
| 18 | 2022-01-09 | Northeastern (236) | 67 | 70 | Towson (103) | Final | L | -3 |
| 19 | 2022-01-11 | Northeastern (300) | 66 | 89 | James Madison (202) | Final | L | -23 |
| 20 | 2022-01-15 | Drexel (215) | 76 | 68 | Northeastern (300) | Final | L | -8 |
| 21 | 2022-01-17 | Delaware (125) | 82 | 76 | Northeastern (255) | Final (OT) | L | -6 |
| 22 | 2022-01-22 | Hofstra (98) | 72 | 50 | Northeastern (300) | Final | L | -22 |
| 23 | 2022-01-24 | UNC-Wilmington (90) | 74 | 68 | Northeastern (300) | Final | L | -6 |
| 24 | 2022-01-27 | Northeastern (300) | 62 | 67 | UNC-Wilmington (90) | Final | L | -5 |
| 25 | 2022-01-29 | Northeastern (300) | 63 | 81 | Charleston (123) | Final | L | -18 |
| 26 | 2022-02-03 | James Madison (202) | 76 | 71 | Northeastern (300) | Final | L | -5 |
| 27 | 2022-02-05 | Towson (152) | 53 | 58 | Northeastern (300) | Final | W | 5 |
| 28 | 2022-02-10 | Northeastern (300) | 61 | 74 | Delaware (287) | Final | L | -13 |
| 29 | 2022-02-12 | Northeastern (300) | 51 | 67 | Drexel (215) | Final | L | -16 |
| 30 | 2022-02-19 | Northeastern (266) | 73 | 76 | Hofstra (105) | Final | L | -3 |
| 31 | 2022-02-22 | Charleston (163) | 83 | 72 | Northeastern (261) | Final | L | -11 |
| 32 | 2022-02-24 | William & Mary (332) | 28 | 62 | Northeastern (261) | Final | W | 34 |
| 33 | 2022-02-26 | Elon (273) | 67 | 54 | Northeastern (261) | Final | L | -13 |
| 34 | 2022-03-05 | Northeastern (264) | 68 | 63 | William & Mary (340) | Final | W | 5 |
| 35 | 2022-03-06 | Northeastern (265) | 61 | 68 | Towson (75) | Final | L | -7 |