Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Southeastern Louisiana (324) | 67 | 70 | Tulane (155) | Final | L | -3 |
| 2 | 2021-11-12 | Southeast Baptist | 58 | 128 | Southeastern Louisiana (318) | Final | W | 70 |
| 3 | 2021-11-14 | Paul Quinn | 60 | 77 | Southeastern Louisiana (318) | Final | W | 17 |
| 4 | 2021-11-18 | Southeastern Louisiana (247) | 61 | 78 | SMU (179) | Final | L | -17 |
| 5 | 2021-11-22 | Ecclesia | 79 | 121 | Southeastern Louisiana (318) | Final | W | 42 |
| 6 | 2021-11-26 | Southeastern Louisiana (318) | 66 | 74 | Purdue Fort Wayne (222) | Final | L | -8 |
| 7 | 2021-11-27 | Southeastern Louisiana (283) | 71 | 90 | Florida Gulf Coast (220) | Final | L | -19 |
| 8 | 2021-11-28 | Western Michigan (309) | 81 | 77 | Southeastern Louisiana (329) | Final (OT) | L | -4 |
| 9 | 2021-12-05 | Southeastern Louisiana (329) | 72 | 68 | Troy (194) | Final | W | 4 |
| 10 | 2021-12-11 | Southeastern Louisiana (318) | 66 | 72 | Southern (259) | Final | L | -6 |
| 11 | 2021-12-14 | Southeastern Louisiana (318) | 60 | 86 | Louisville (21) | Final | L | -26 |
| 12 | 2021-12-19 | Southeastern Louisiana (318) | 54 | 77 | Iowa State (7) | Final | L | -23 |
| 13 | 2021-12-21 | Southeastern Louisiana (318) | 62 | 93 | Iowa (28) | Final | L | -31 |
| 14 | 2021-12-29 | Millsaps | 0 | 0 | Southeastern Louisiana (318) | Cancelled | - | - |
| 15 | 2022-01-06 | Southeastern Louisiana (318) | 90 | 81 | Houston Christian (305) | Final | W | 9 |
| 16 | 2022-01-06 | Southeastern Louisiana (305) | 90 | 81 | Houston Baptist (318) | Final | W | 9 |
| 17 | 2022-01-07 | Southeastern Louisiana (318) | 83 | 78 | McNeese (63) | Final | W | 5 |
| 18 | 2022-01-07 | Southeastern Louisiana (305) | 83 | 78 | McNeese State (295) | Final | W | 5 |
| 19 | 2022-01-08 | Southeastern Louisiana (318) | 77 | 72 | Nicholls State (250) | Final | W | 5 |
| 20 | 2022-01-12 | Tougaloo | 72 | 77 | Southeastern Louisiana (270) | Final | W | 5 |
| 21 | 2022-01-15 | Northwestern State (315) | 74 | 79 | Southeastern Louisiana (318) | Final | W | 5 |
| 22 | 2022-01-20 | Southeastern Louisiana (318) | 72 | 78 | New Orleans (236) | Final | L | -6 |
| 23 | 2022-01-22 | Southeastern Louisiana (318) | 101 | 93 | Nicholls State (250) | Final | W | 8 |
| 24 | 2022-01-27 | Texas A&M-Corpus Christi (208) | 86 | 71 | Southeastern Louisiana (318) | Final | L | -15 |
| 25 | 2022-01-29 | Incarnate Word (280) | 68 | 78 | Southeastern Louisiana (318) | Final | W | 10 |
| 26 | 2022-02-03 | Southeastern Louisiana (318) | 83 | 78 | McNeese (63) | Final | W | 5 |
| 27 | 2022-02-03 | Southeastern Louisiana (268) | 83 | 78 | McNeese State (288) | Final | W | 5 |
| 28 | 2022-02-05 | Southeastern Louisiana (318) | 80 | 93 | Houston Christian (305) | Final | L | -13 |
| 29 | 2022-02-05 | Southeastern Louisiana (268) | 80 | 93 | Houston Baptist (338) | Final | L | -13 |
| 30 | 2022-02-10 | McNeese State (289) | 86 | 91 | Southeastern Louisiana (274) | Final | W | 5 |
| 31 | 2022-02-12 | Houston Baptist (333) | 84 | 89 | Southeastern Louisiana (274) | Final | W | 5 |
| 32 | 2022-02-17 | Southeastern Louisiana (318) | 83 | 74 | Texas A&M-Corpus Christi (208) | Final | W | 9 |
| 33 | 2022-02-19 | Southeastern Louisiana (264) | 84 | 92 | Incarnate Word (351) | Final | L | -8 |
| 34 | 2022-02-24 | New Orleans (212) | 79 | 84 | Southeastern Louisiana (265) | Final | W | 5 |
| 35 | 2022-02-26 | Nicholls State (199) | 81 | 83 | Southeastern Louisiana (265) | Final | W | 2 |
| 36 | 2022-03-05 | Southeastern Louisiana (250) | 85 | 80 | Northwestern State (326) | Final | W | 5 |
| 37 | 2022-03-11 | New Orleans (234) | 65 | 74 | Southeastern Louisiana (242) | Final | W | 9 |
| 38 | 2022-03-12 | Texas A&M-Corpus Christi (245) | 73 | 65 | Southeastern Louisiana (242) | Final | L | -8 |
| 39 | 2022-03-16 | Southeastern Louisiana (318) | 68 | 70 | South Alabama (177) | Final | L | -2 |