Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | LSU (26) | 74 | 62 | Nicholls State (159) | Final | L | -12 |
| 2 | 2021-11-09 | Nicholls State (159) | 62 | 58 | Northern Iowa (204) | Final | W | 4 |
| 3 | 2021-11-12 | Carver Bible | 52 | 120 | Nicholls State (159) | Final | W | 68 |
| 4 | 2021-11-13 | Carver Bible | 44 | 101 | Nicholls State (159) | Final | W | 57 |
| 5 | 2021-11-15 | Nicholls State (87) | 60 | 89 | Baylor (109) | Final | L | -29 |
| 6 | 2021-11-18 | Nicholls State (87) | 50 | 63 | TCU (121) | Final | L | -13 |
| 7 | 2021-11-22 | Nicholls State (250) | 75 | 72 | Cal Poly (238) | Final/OT | W | 3 |
| 8 | 2021-11-24 | Utah Valley (91) | 74 | 63 | Nicholls State (250) | Final | L | -11 |
| 9 | 2021-11-27 | Southwestern Christian | 58 | 87 | Nicholls State (157) | Final | W | 29 |
| 10 | 2021-12-09 | Nicholls State (171) | 95 | 80 | Mississippi Valley State (347) | Final | W | 15 |
| 11 | 2021-12-13 | Blue Mountain | 69 | 87 | Nicholls State (250) | Final | W | 18 |
| 12 | 2021-12-15 | Nicholls State (250) | 68 | 71 | Wisconsin (24) | Final | L | -3 |
| 13 | 2021-12-18 | Mississippi Valley State (365) | 73 | 104 | Nicholls State (250) | Final | W | 31 |
| 14 | 2021-12-21 | Nicholls State (250) | 61 | 83 | Oregon State (144) | Final | L | -22 |
| 15 | 2021-12-29 | Nicholls State (250) | 90 | 104 | Purdue (8) | Final | L | -14 |
| 16 | 2022-01-06 | Nicholls State (250) | 87 | 56 | Incarnate Word (280) | Final | W | 31 |
| 17 | 2022-01-07 | Texas A&M-Corpus Christi (208) | 75 | 84 | Nicholls State (250) | Final | W | 9 |
| 18 | 2022-01-08 | Southeastern Louisiana (318) | 77 | 72 | Nicholls State (250) | Final | L | -5 |
| 19 | 2022-01-15 | Nicholls State (250) | 66 | 78 | New Orleans (236) | Final | L | -12 |
| 20 | 2022-01-20 | Northwestern State (315) | 58 | 69 | Nicholls State (250) | Final | W | 11 |
| 21 | 2022-01-22 | Southeastern Louisiana (318) | 101 | 93 | Nicholls State (250) | Final | L | -8 |
| 22 | 2022-01-27 | Nicholls State (250) | 81 | 71 | McNeese (63) | Final | W | 10 |
| 23 | 2022-01-27 | Nicholls State (234) | 81 | 71 | McNeese State (280) | Final | W | 10 |
| 24 | 2022-01-29 | Nicholls State (250) | 73 | 61 | Houston Christian (305) | Final | W | 12 |
| 25 | 2022-01-29 | Nicholls State (215) | 73 | 61 | Houston Baptist (338) | Final | W | 12 |
| 26 | 2022-02-03 | Nicholls State (250) | 63 | 60 | Incarnate Word (280) | Final | W | 3 |
| 27 | 2022-02-10 | Incarnate Word (280) | 58 | 69 | Nicholls State (250) | Final | W | 11 |
| 28 | 2022-02-12 | Texas A&M-Corpus Christi (208) | 80 | 83 | Nicholls State (250) | Final/OT | W | 3 |
| 29 | 2022-02-17 | McNeese State (292) | 73 | 82 | Nicholls State (207) | Final | W | 9 |
| 30 | 2022-02-19 | Houston Baptist (325) | 70 | 84 | Nicholls State (207) | Final | W | 14 |
| 31 | 2022-02-24 | Nicholls State (199) | 80 | 62 | Northwestern State (331) | Final | W | 18 |
| 32 | 2022-02-26 | Nicholls State (199) | 81 | 83 | Southeastern Louisiana (265) | Final | L | -2 |
| 33 | 2022-03-02 | Nicholls State (201) | 86 | 75 | Texas A&M-Corpus Christi (242) | Final | W | 11 |
| 34 | 2022-03-05 | New Orleans (234) | 85 | 92 | Nicholls State (201) | Final | W | 7 |
| 35 | 2022-03-11 | Texas A&M-Corpus Christi (245) | 71 | 64 | Nicholls State (193) | Final | L | -7 |
| 36 | 2022-03-16 | Nicholls State (250) | 58 | 68 | SMU (45) | Final | L | -10 |