Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | McNeese State (318) | 62 | 86 | SMU (54) | Final | L | -24 |
| 2 | 2021-11-11 | McNeese State (318) | 61 | 77 | TCU (113) | Final | L | -16 |
| 3 | 2021-11-15 | Champion Christian | 66 | 116 | McNeese State (344) | Final | W | 50 |
| 4 | 2021-11-18 | McNeese State (344) | 46 | 85 | LSU (15) | Final | L | -39 |
| 5 | 2021-11-22 | Carver Bible | 54 | 98 | McNeese State (285) | Final | W | 44 |
| 6 | 2021-11-26 | McNeese State (285) | 71 | 59 | St. Francis (NY) (344) | Final | W | 12 |
| 7 | 2021-11-27 | McNeese State (285) | 75 | 83 | Samford (196) | Final | L | -8 |
| 8 | 2021-12-01 | McNeese State (271) | 62 | 78 | Seattle (101) | Final | L | -16 |
| 9 | 2021-12-04 | McNeese State (271) | 58 | 79 | Wyoming (32) | Final | L | -21 |
| 10 | 2021-12-08 | McNeese State (290) | 68 | 83 | Louisiana (246) | Final | L | -15 |
| 11 | 2021-12-16 | McNeese State (289) | 72 | 82 | UTEP (200) | Final | L | -10 |
| 12 | 2021-12-18 | Dallas Christian | 0 | 0 | McNeese State (289) | Cancelled | - | - |
| 13 | 2021-12-21 | McNeese State (300) | 59 | 74 | Kansas State (89) | Final | L | -15 |
| 14 | 2021-12-30 | Ecclesia | 66 | 115 | McNeese State (302) | Final | W | 49 |
| 15 | 2022-01-06 | New Orleans (265) | 82 | 92 | McNeese State (295) | Final (2OT) | W | 10 |
| 16 | 2022-01-07 | Southeastern Louisiana (305) | 83 | 78 | McNeese State (295) | Final | L | -5 |
| 17 | 2022-01-08 | McNeese State (295) | 54 | 67 | Texas A&M-Corpus Christi (155) | Final | L | -13 |
| 18 | 2022-01-12 | Arlington Baptist | 44 | 120 | McNeese State (295) | Final | W | 76 |
| 19 | 2022-01-15 | Houston Baptist (343) | 75 | 78 | McNeese State (295) | Final | W | 3 |
| 20 | 2022-01-20 | McNeese State (283) | 56 | 60 | Texas A&M-Corpus Christi (163) | Final | L | -4 |
| 21 | 2022-01-22 | McNeese State (283) | 82 | 72 | Incarnate Word (349) | Final | W | 10 |
| 22 | 2022-01-27 | Nicholls State (234) | 81 | 71 | McNeese State (280) | Final | L | -10 |
| 23 | 2022-01-30 | New Orleans (223) | 84 | 78 | McNeese State (288) | Final | L | -6 |
| 24 | 2022-02-03 | Southeastern Louisiana (268) | 83 | 78 | McNeese State (288) | Final | L | -5 |
| 25 | 2022-02-05 | Northwestern State (331) | 84 | 93 | McNeese State (288) | Final | W | 9 |
| 26 | 2022-02-10 | McNeese State (289) | 86 | 91 | Southeastern Louisiana (274) | Final | L | -5 |
| 27 | 2022-02-12 | McNeese State (289) | 80 | 75 | Northwestern State (319) | Final | W | 5 |
| 28 | 2022-02-17 | McNeese State (292) | 73 | 82 | Nicholls State (207) | Final | L | -9 |
| 29 | 2022-02-19 | McNeese State (292) | 75 | 88 | New Orleans (217) | Final | L | -13 |
| 30 | 2022-02-24 | Texas A&M-Corpus Christi (252) | 65 | 53 | McNeese State (299) | Final | L | -12 |
| 31 | 2022-02-26 | Incarnate Word (348) | 69 | 67 | McNeese State (299) | Final | L | -2 |
| 32 | 2022-03-05 | McNeese State (308) | 144 | 149 | Houston Baptist (327) | Final | L | -5 |
| 33 | 2022-03-09 | McNeese State (312) | 80 | 67 | Northwestern State (332) | Final | W | 13 |
| 34 | 2022-03-10 | McNeese State (312) | 78 | 82 | New Orleans (234) | Final | L | -4 |