Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Alcorn State (329) | 67 | 85 | Washington State (101) | Final | W | 18 |
| 2 | 2021-11-12 | Seattle (118) | 61 | 79 | Washington State (179) | Final | W | 18 |
| 3 | 2021-11-15 | UC-Santa Barbara (138) | 65 | 73 | Washington State (43) | Final | W | 8 |
| 4 | 2021-11-18 | Washington State (43) | 109 | 61 | Idaho (276) | Final | W | 48 |
| 5 | 2021-11-22 | Winthrop (133) | 86 | 92 | Washington State (179) | Final | W | 6 |
| 6 | 2021-11-27 | Eastern Washington (274) | 76 | 71 | Washington State (14) | Final | L | -5 |
| 7 | 2021-12-01 | Washington State (179) | 51 | 29 | Arizona State (61) | Final | W | 22 |
| 8 | 2021-12-04 | USC (71) | 63 | 61 | Washington State (179) | Final | L | -2 |
| 9 | 2021-12-08 | Weber State (35) | 60 | 94 | Washington State (74) | Final | W | 34 |
| 10 | 2021-12-11 | South Dakota State (268) | 77 | 74 | Washington State (179) | Final | L | -3 |
| 11 | 2021-12-15 | New Mexico State (207) | 64 | 61 | Washington State (179) | Final | L | -3 |
| 12 | 2021-12-18 | Northern Colorado (196) | 56 | 82 | Washington State (179) | Final | W | 26 |
| 13 | 2021-12-22 | Boise State (62) | 58 | 52 | Washington State (179) | Final | L | -6 |
| 14 | 2021-12-29 | Washington (72) | 0 | 0 | Washington State (179) | Postponed | - | - |
| 15 | 2022-01-06 | Washington State (179) | 78 | 83 | Colorado (73) | Final | L | -5 |
| 16 | 2022-01-08 | Washington State (179) | 77 | 61 | Utah (130) | Final | W | 16 |
| 17 | 2022-01-13 | Stanford (60) | 62 | 57 | Washington State (179) | Final | L | -5 |
| 18 | 2022-01-15 | California (65) | 57 | 65 | Washington State (179) | Final | W | 8 |
| 19 | 2022-01-20 | Washington State (179) | 0 | 0 | Oregon (102) | Postponed | - | - |
| 20 | 2022-01-22 | Washington State (179) | 0 | 0 | Oregon State (144) | Postponed | - | - |
| 21 | 2022-01-26 | Utah (135) | 54 | 71 | Washington State (78) | Final | W | 17 |
| 22 | 2022-01-30 | Colorado (74) | 43 | 70 | Washington State (67) | Final | W | 27 |
| 23 | 2022-02-03 | Washington State (179) | 66 | 60 | Stanford (60) | Final | W | 6 |
| 24 | 2022-02-05 | Washington State (179) | 68 | 64 | California (65) | Final | W | 4 |
| 25 | 2022-02-10 | Arizona (2) | 72 | 60 | Washington State (179) | Final | L | -12 |
| 26 | 2022-02-12 | Arizona State (61) | 58 | 55 | Washington State (179) | Final | L | -3 |
| 27 | 2022-02-14 | Washington State (179) | 59 | 62 | Oregon (102) | Final | L | -3 |
| 28 | 2022-02-17 | Washington State (179) | 56 | 76 | UCLA (30) | Final | L | -20 |
| 29 | 2022-02-20 | Washington State (76) | 60 | 62 | USC (18) | Final | L | -2 |
| 30 | 2022-02-23 | Washington (109) | 70 | 78 | Washington State (76) | Final | W | 8 |
| 31 | 2022-02-26 | Washington State (76) | 70 | 78 | Washington (109) | Final | L | -8 |
| 32 | 2022-02-28 | Washington State (77) | 103 | 97 | Oregon State (277) | Final | W | 6 |
| 33 | 2022-03-03 | Oregon State (277) | 67 | 71 | Washington State (77) | Final | W | 4 |
| 34 | 2022-03-05 | Oregon (56) | 74 | 94 | Washington State (77) | Final | W | 20 |
| 35 | 2022-03-09 | California (136) | 59 | 66 | Washington State (74) | Final | W | 7 |
| 36 | 2022-03-10 | Washington State (74) | 65 | 75 | UCLA (13) | Final | L | -10 |
| 37 | 2022-03-15 | Santa Clara (70) | 50 | 63 | Washington State (69) | Final | W | 13 |
| 38 | 2022-03-20 | Washington State (69) | 75 | 63 | SMU (47) | Final | W | 12 |
| 39 | 2022-03-23 | Washington State (69) | 77 | 58 | BYU (64) | Final | W | 19 |
| 40 | 2022-03-29 | Washington State (69) | 56 | 72 | Texas A&M (38) | Final | L | -16 |