Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Voorhees | 42 | 92 | South Florida (164) | Final | W | 50 |
| 2 | 2021-11-09 | Bethune-Cookman | 54 | 75 | South Florida (164) | Final | W | 21 |
| 3 | 2021-11-13 | Georgia Southern (216) | 53 | 41 | South Florida (164) | Final | L | -12 |
| 4 | 2021-11-15 | North Carolina A&T (297) | 54 | 56 | South Florida (166) | Final | W | 2 |
| 5 | 2021-11-19 | Auburn (37) | 58 | 52 | South Florida (52) | Final | L | -6 |
| 6 | 2021-11-24 | Hampton (260) | 52 | 58 | South Florida (52) | Final | W | 6 |
| 7 | 2021-11-29 | South Florida (169) | 49 | 64 | Boston College (112) | Final | L | -15 |
| 8 | 2021-12-03 | South Carolina State (355) | 65 | 64 | South Florida (52) | Final | L | -1 |
| 9 | 2021-12-14 | Austin Peay (138) | 51 | 60 | South Florida (52) | Final | W | 9 |
| 10 | 2021-12-18 | South Florida (52) | 55 | 66 | Florida (6) | Final | L | -11 |
| 11 | 2021-12-22 | BYU (23) | 54 | 39 | South Florida (52) | Final | L | -15 |
| 12 | 2021-12-23 | South Florida (52) | 76 | 69 | Hawaii (109) | Final | W | 7 |
| 13 | 2021-12-24 | South Florida (237) | 76 | 69 | Hawaii (231) | Final | W | 7 |
| 14 | 2021-12-25 | Wyoming (103) | 77 | 57 | South Florida (52) | Final | L | -20 |
| 15 | 2021-12-29 | Mississippi Valley State (365) | 0 | 0 | South Florida (52) | Cancelled | - | - |
| 16 | 2022-01-01 | East Carolina (252) | 0 | 0 | South Florida (52) | Postponed | - | - |
| 17 | 2022-01-05 | Houston (5) | 83 | 66 | South Florida (52) | Final | L | -17 |
| 18 | 2022-01-08 | South Florida (52) | 54 | 68 | Tulane (167) | Final | L | -14 |
| 19 | 2022-01-12 | South Florida (243) | 65 | 77 | SMU (72) | Final | L | -12 |
| 20 | 2022-01-15 | Central Florida (43) | 51 | 75 | South Florida (52) | Final | W | 24 |
| 21 | 2022-01-18 | South Florida (52) | 55 | 74 | Houston (5) | Final | L | -19 |
| 22 | 2022-01-22 | Temple (169) | 0 | 0 | South Florida (52) | Postponed | - | - |
| 23 | 2022-01-26 | SMU (57) | 74 | 54 | South Florida (204) | Final | L | -20 |
| 24 | 2022-01-29 | South Florida (52) | 45 | 76 | Tulsa (55) | Final | L | -31 |
| 25 | 2022-02-03 | South Florida (52) | 49 | 68 | Central Florida (43) | Final | L | -19 |
| 26 | 2022-02-07 | Temple (169) | 49 | 52 | South Florida (52) | Final | W | 3 |
| 27 | 2022-02-09 | Cincinnati (54) | 70 | 59 | South Florida (52) | Final | L | -11 |
| 28 | 2022-02-12 | South Florida (52) | 69 | 73 | Wichita State (76) | Final | L | -4 |
| 29 | 2022-02-15 | Tulane (113) | 76 | 57 | South Florida (224) | Final | L | -19 |
| 30 | 2022-02-17 | East Carolina (252) | 65 | 57 | South Florida (52) | Final | L | -8 |
| 31 | 2022-02-19 | Tulsa (194) | 65 | 57 | South Florida (224) | Final | L | -8 |
| 32 | 2022-02-23 | South Florida (245) | 60 | 64 | East Carolina (148) | Final | L | -4 |
| 33 | 2022-02-26 | South Florida (245) | 56 | 54 | Cincinnati (95) | Final | W | 2 |
| 34 | 2022-03-03 | Memphis (47) | 73 | 64 | South Florida (233) | Final | L | -9 |
| 35 | 2022-03-06 | South Florida (237) | 47 | 75 | Temple (99) | Final | L | -28 |
| 36 | 2022-03-10 | South Florida (237) | 58 | 60 | Central Florida (88) | Final | L | -2 |